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NEAT1 promotes osteogenic differentiation in human bone marrow-derived mesenchymal stem cells by regulating miR-29b-3p/BMP1 axis.
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BMP1 is upregulated in gastric cancer and is correlated with poor patient survival.
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investigate the effects of the functional 5'UTR + 104 (T/C) variant of BMP1 on serum ApoA1 and HDL levels and risk of coronary heart disease. Our results indicated that the BMP1 5'UTR + 104 (T/C) variation may affect the serum ApoA1 and lipoprotein levels depending on statin therapy so that contributes to the development of coronary heart disease.
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Mechanical stress affects the osteogenic differentiation of human ligamentum flavum cells via the BMP-Smad1 signaling pathway.
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For meprin beta a reduction and for BMP-1 an increase in activity was reported under increasing calcium concentrations.
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BMP1 c.941G>A (p.(R314H)) variant was identified in the family with Chiari malformation type 1.
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Results indicate the significance of follistatin-like protein 1 (FSTL1) in driving oncogenesis and metastasis in esophageal squamous cell carcinoma (ESCC) by coordinating NF-kappa B (NFkappaB) and bone morphogenetic proteins (BMP) pathway control.
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Given the association of BMP1-related Osteogenesis Imperfecta (OI) with very high bone material density, concerns remain whether anti-resorptive therapy is indicated in this ultra-rare form of OI
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Data show that the KKN1 fragment generated by BMP1-cleavage of WFIKKN1 protein contributes most significantly to the observed enhancer activity.
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a previously unknown O-glycosylation site and Asn-hydroxylation site, indicating a novel feature of BMP-1 in the EGF domain. The study clearly outlines the benefit of in-depth characterization of overexpressed proteins to deduce important protein modifications.
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BMP-1 accelerates the connective tissue growth factor production dependently on cellular internalization in human dental pulp cells, indicating a novel property of BMP-1 which potentially enhances bone-like reparative dentin formation.
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Studies indicate crosstalk between Notch receptor and Wnt protein, Hedgehog protein, hypoxia and transforming growth factor beta (TGFbeta)/bone morphogenetic protein (BMP) pathways.
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study thus highlights the severe and progressive nature of BMP1-associated OI in adults and broadens insights into the functional consequences of BMP1/mTLD-deficiency on ECM organization.
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Data indicate that BMP-1 can simultaneously trigger matrix assembly and boost the synthesis of matrix proteins via a direct effect on growth factors in the contexts of development, growth and tissue repair. [review]
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Two novel variants in the BMP1 gene: c.808A>G and c.1297G>T care associated with osteogenesis imperfecta.
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Frequent bone fracture in children is cause by BMP1-1 deficiency.
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mutations of the DSP-PP P4 to P4' cleavage site can block, impair or accelerate dentin sialoprotein phosphophoryn cleavage, and suggest that its Bone morphogenic protein 1 cleavage site is conserved in order to regulate its cleavage efficiency
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High BMP1 expression is associated with type-1 diabetes.
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Loss of bone morphogenetic protein is associated with prostate cancer.
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miR-194 suppresses metastasis of non-small cell lung cancer through regulating expression of BMP1 and p27kip1