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anti-Human BMP1 Antikörper:
anti-Mouse (Murine) BMP1 Antikörper:
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Human Polyclonal BMP1 Primary Antibody für IHC (p), ELISA - ABIN544628
Garrigue-Antar, Hartigan, Kadler: Post-translational modification of bone morphogenetic protein-1 is required for secretion and stability of the protein. in The Journal of biological chemistry 2002
Show all 3 Pubmed References
Human Polyclonal BMP1 Primary Antibody für ELISA, IHC - ABIN4284876
Tovar-Vidales, Fitzgerald, Clark, Wordinger: Transforming growth factor-β2 induces expression of biologically active bone morphogenetic protein-1 in human trabecular meshwork cells. in Investigative ophthalmology & visual science 2013
NEAT1 promotes osteogenic differentiation in human bone marrow-derived mesenchymal stem cells by regulating miR-29b-3p/BMP1 axis.
BMP1 is upregulated in gastric cancer and is correlated with poor patient survival.
investigate the effects of the functional 5'UTR + 104 (T/C) variant of BMP1 on serum ApoA1 and HDL levels and risk of coronary heart disease. Our results indicated that the BMP1 5'UTR + 104 (T/C) variation may affect the serum ApoA1 and lipoprotein levels depending on statin therapy so that contributes to the development of coronary heart disease.
Mechanical stress affects the osteogenic differentiation of human ligamentum flavum cells via the BMP-Smad1 signaling pathway.
For meprin beta a reduction and for BMP-1 an increase in activity was reported under increasing calcium concentrations.
BMP1 c.941G>A (p.(R314H)) variant was identified in the family with Chiari malformation type 1.
Results indicate the significance of follistatin-like protein 1 (FSTL1) in driving oncogenesis and metastasis in esophageal squamous cell carcinoma (ESCC) by coordinating NF-kappa B (NFkappaB) and bone morphogenetic proteins (BMP) pathway control.
Given the association of BMP1-related Osteogenesis Imperfecta (OI) with very high bone material density, concerns remain whether anti-resorptive therapy is indicated in this ultra-rare form of OI
Data show that the KKN1 fragment generated by BMP1-cleavage of WFIKKN1 protein contributes most significantly to the observed enhancer activity.
a previously unknown O-glycosylation site and Asn-hydroxylation site, indicating a novel feature of BMP-1 in the EGF domain. The study clearly outlines the benefit of in-depth characterization of overexpressed proteins to deduce important protein modifications.
BMP-1 accelerates the connective tissue growth factor production dependently on cellular internalization in human dental pulp cells, indicating a novel property of BMP-1 which potentially enhances bone-like reparative dentin formation.
Studies indicate crosstalk between Notch receptor and Wnt protein, Hedgehog protein, hypoxia and transforming growth factor beta (TGFbeta)/bone morphogenetic protein (BMP) pathways.
study thus highlights the severe and progressive nature of BMP1-associated OI in adults and broadens insights into the functional consequences of BMP1/mTLD-deficiency on ECM organization.
Data indicate that BMP-1 can simultaneously trigger matrix assembly and boost the synthesis of matrix proteins via a direct effect on growth factors in the contexts of development, growth and tissue repair. [review]
Two novel variants in the BMP1 gene: c.808A>G and c.1297G>T care associated with osteogenesis imperfecta.
Frequent bone fracture in children is cause by BMP1-1 deficiency.
mutations of the DSP-PP P4 to P4' cleavage site can block, impair or accelerate dentin sialoprotein phosphophoryn cleavage, and suggest that its Bone morphogenic protein 1 cleavage site is conserved in order to regulate its cleavage efficiency
High BMP1 expression is associated with type-1 diabetes.
Loss of bone morphogenetic protein is associated with prostate cancer.
miR-194 suppresses metastasis of non-small cell lung cancer through regulating expression of BMP1 and p27kip1
Study show that integrin alpha9beta1 antagonizes both alpha3beta1-dependent mTLD/BMP-1 expression and basement membrane (BM) assembly/maturation. These findings indicate a complex interplay between these two integrins whereby alpha3beta1 promotes, and coordinately, alpha9beta1 inhibits mTLD/BMP-1 production and laminin-gamma2 processing to effect timely BM assembly and maturation during wound healing.
Biochemical studies identify a Bmp-mTORC1-Hif1a signaling cascade resulting in upregulation of Glut1 in chondrocytes that is essential for murine skeletal development.
Loss of BMP1-like proteinase activity is shown to result in markedly thinned and fragile skin with unusually densely packed collagen fibrils and delayed wound healing.
plays crucial role in maintaining extracellular matrix homeostasis essential to root formation and dentin mineralization
Bone morphogenetic protein and retinoic acid synergistically specify female germ-cell fate in mice.
the proteinases encoded by Bmp1 and Tll1 genes play essential roles in the development and maintenance of mouse dentin and periodontal ligaments.
The presented data demonstrate Bmp1/Tll1 products to be of profound importance to bone growth and modeling.
Bone morphogenetic protein-1 processes insulin-like growth factor-binding protein 3.
during endochondral ossification, BMP and TGFbeta signaling can have antagonistic effects on chondrocyte proliferation and differentiation in vivo
BMP-1 protein was expressed in type I and IIa but not in IIb muscle fibers. BMP-1 mRNA levels were unaffected by either food deprivation or hindlimb suspension.
periostin supported BMP-1-mediated proteolytic activation of LOX on the extracellular matrix, which promoted collagen cross-linking.
products of Bmp1 and Tll1 are responsible for in vivo cleavage of Chordin in mammals
processing of the prodomain of OGN by BMP-1 potentiates the ability of OGN to modulate the formation of collagen fibrils
BMP1 cleaves LTBP1 at two specific sites, liberating the large latent complex from the extracellular matrix and resulting in consequent activation of TGFbeta1 via cleavage of its prodomain, latency-associated peptide, by non-BMP1-like proteinases.
BMP signaling promotes the generation of astrocytes and mature, myelinating oligodendrocytes in vivo but does not affect oligodendrocyte precursor development, thus suggesting tight regulation of BMP signaling to ensure proper gliogenesis
Bmp1 processes prl to a 17-kDa anti-angiogenic factor.
proteolytic cleavage of the propeptide by BMP-1/TLD proteases plays a critical role in the activation of latent myostatin in vivo
FN binds BMP1-like proteinases in vivo and that FN is an important determinant of the in vivo activity levels of BMP1-like proteinases.
Sizzled is unique among secreted frizzled-related proteins for its ability to specifically inhibit bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases
Crescent is a new component of the dorsal-ventral patterning pathway, which functions as the dorsal counterpart of Sizzled, through the regulation of chordinases of the Tolloid family.
The molecular and cellular bases of BMP1-dependent osteogenesis were defined. The importance of BMP1 for bone formation and stability were shown in humans and zebrafish.
zebrafish Tsg1 promotes BMP signaling, and thus ventral cell fates, during DV axial patterning
This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region.
mammalian tolloid protein
, procollagen C-endopeptidase
, procollagen C-proteinase
, bone morphogenetic protein 1
, Bone morphogenetic protein 1
, bone morphogenetic protein 1-like
, bone morphogenetic protein 1a