Anti-Parietal Cell ELISA Kit

Produktnummer ABIN930717

Dieses Human ELISA-Kit ist ein Colorimetric ELISA-Kit, das dafür entwickelt wurde, Human zu quantifizieren.

Kurzübersicht für Anti-Parietal Cell ELISA Kit (ABIN930717)

Target: Anti-Parietal Cell

Reaktivität: Human

Nachweismethode: Colorimetric

Methodentyp: Sandwich ELISA

Applikation: ELISA

Produktdetails

Analytische Methode: Quantitative

Produktmerkmale: ELISA kit for the detection of Parietal Cell in the research laboratory
Alternative Names: Parietal cell ELISA kit

Aufreinigung: Ascites, ammnonium sulphate purified

Anwendungsinformationen

Applikationshinweise: Optimal conditions to be determined by end-user

Plattentyp: Pre-coated

Testdurchführung:

AntiParietal Cell (H+/K+ATPase) is an indirect solid phase enzyme immunometric assay (ELISA). It is designed for the quantitative measurement of IgG class autoantibodies directed against the a and bsubunits of the Parietal Cell H+/K+ATPase. Preparations of highly purified pig Parietal Cell H+/K+ATPase are coated on microplates. The microplates can be divided into 12 modules of 8 wells each or can be used completely for 96 determinations. Each well can be separated from the module (

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8 °C.

Antigendetails

Target: Anti-Parietal Cell

Substanzklasse: Antibody

Hintergrund: Autoantibodies against the H/K ATPase can be detected in 80-90 % of pernicious anemia patients, by indirect immunofluorescence and they are also detected in 20 % of the healthy adult population. ELISA test systems show a sensitivity of about 80 % and specificity of about 90 %. There is an age related increase in the presence of parietal cell autoantibodies in the adult population. A study of the relationship between parietal cell autoantibody and gastric mucosal morphology, indicates these parietal cell positive individuals in a random population may indeed have early type A gastritis. Higher prevalence rates (20-30 %) of parietal cell autoantibodies have been noted in patients with autoimmune endocrine disorders such as thyrotoxicosis, Hashimoto's thyroiditis and insulin-dependent diabetes. Histological examinations of gastric biopsies reveals that the majority of parietal cell autoantibody positive individuals also have a type A gastric lesion.
Synonyms: Parietal cell ELISA kit.