anti-IL-4 (IL4) Antikörper

Human Interleukin 4 (IL4) Interaktionspartner

1. n this study, CMV-DRibbles derived from MDA cell lines expressing cytomegalovirus (CMV) pp65 protein were loaded onto human IFN-DC and IL-4-DC derived from monocytes, respectively. We observed that CMV-DRibbles resulted in the up-regulation of HLA-DR, CD11c, and CD83, but not co-stimulatory molecules CD 80 and CD86 on IFN-DC

2. IL4 expression was down-regulated in the preeclampsia placenta and serum.

3. Polymorphism of the IL-1beta, TNF, IL-1RA and IL-4 Cytokine Genes Significantly Increases the Risk of Preterm Birth

4. Only two haplotypes (A1) & (A2) of IL-4 (VNTR) gene were recognized among Egyptian population; (A2) allele may influence in diabetes but not its complication (neuropathy) among Egyptian diabetic patients.

5. data show the crucial role of IL-4 in the pathogenesis of neuromyelitis optica and multiple sclerosis diseases; future studies should investigate the serum level of IL-4 in NMO and MS patients to clarify more roles of this cytokine in the pathogenesis of both diseases

6. Those who had top quartile concentrations of IL-4 and/or IL-10 on postnatal days 21 and/or 28 were more likely than their peers to have low scores on components of the NEPSY-II.

7. The frequency of IL-4-590 single nucleotide polymorphism (SNP) CT and TT genotypes was statistically higher among AIH patients than controls.

8. IL-4 can contribute to the shift of balance of IgG subclasses toward IgG4 compared to the other Tfh2-related cytokines in IgG4-RD.

9. data demonstrated a novel effect on TRAIL sensitivity on monocytes and monocytic leukemia cells of IL-4 and suggested that it may be necessary to reconsider the impact of current therapies against IL-4, JAK/STAT, and PI3K/Akt pathways with regard to TRAIL sensitivity

10. among the carriers of the C/C genotype, IL-4 level was 1.44 higher in brucellosis than in T/T genotype carriers and 1.2 times higher in comparison with the C/T genotype. Among carriers of the C/T genotype, there is a significantly increased risk of brucellosis

11. IL-4 likewise dampens MRGPRX2 expression and cooperates with SCF.

12. The dysfunction of hepatopancreatobiliary system is more significant in the TT-genotype carriers of IL-4 gene

13. the IL-4 (-590C>T; rs2243250) and STAT6 (rs3024974) promoter genes are susceptibility factors for schistosomiasis among schoolchildren in Nigeria. Cytokine IL-4 in particular is essential for regulating disease burden in patients infected with S. haematobium, with worse disease burden among carriers of the rs2243250T/T variant.

14. Study shows that in the absence of IL-2 or IL-12, naive cord blood CD8+ T cells have a natural propensity to differentiate into IL-4-producing non-classic TC2 cells when they are activated alone, or in the presence of TGF-beta and/or inflammatory cytokines. In vivo, colonic mucosa of children with colitis had significantly increased expression of IL-4 in CD8+ T cells compared with controls.

15. Serum IL-4 level and its gene polymorphism were not found to have any increased risk of familial Mediterranean fever occurrence, disease severity, or response to treatment in the Egyptian children

16. this study shows that modulation of the IL-21 pathway with IL-4 distinguishes Common Variable Immunodeficiency patients with more non-infectious clinical complications

17. An increasing number of studies suggest that differential expression of anti-inflammatory cytokines (IL-4, Il-10, TGFB1) occurs in women with endometriosis. (Review)

18. IL4 SNPs were not associated with the risk of endometrial cancer in Chinese Han women.

19. GWA study indicated potential associations between IL-4 polymorphisms and lung cancer susceptibility in China.

20. result showed that the RP2/RP2 genotype of the IL-4 VNTR polymorphism could be a protective factor for breast cancer susceptibility

Mouse (Murine) Interleukin 4 (IL4) Interaktionspartner

1. The NLRP3 inflammasome is upregulated in activated astrocytes. HMGB1 could effectively promote NLRP3 inflammasome formation in astrocytes, by activating NF-kappaB. IL4 could inhibit NLRP3 inflammasome formation, through negative regulation NF-kappaB and promotion PPARgamma activation.

2. IL4 modulates microglia homeostasis and attenuates the early slowly progressive phase of amyotrophic lateral sclerosis.

3. IL-4 and IL-21 play nonredundant roles in the phased progression of germinal center B cell development that can initiate in the combined absence of these cytokine signals

4. During clearance of Citrobacter rodentium infection infection, the concomitant increase in IL-4 protects and maintains goblet cell function against the increasing levels of TNF-alpha and IFN-gamma

5. that IL4 (interleukin 4), a key effector Th2 cytokine in allergic asthma, was critical for autophagy induction in B cells both in vivo and in vitro

6. High IL6 expression is associated with emphysema development in Chronic obstructive pulmonary disease.

7. IL4 induces CCL17 production by acting through IRF4 in human monocytes and murine macrophages.

8. These findings highlight the cross-talk between IL-5 receptor and CD300f as a novel pathway regulating adipose tissue eosinophils.

9. thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development; findings indicate that there is a compartmentalized medullary environment in which differentiation of a minor and highly specialized epithelial subset has a non-redundant role in shaping thymic function

10. A microRNA array technique and IL-4 transgenic mice were used to demonstrate that IL-4 dysregulates microRNAs involved in inflammation, angiogenesis, lymphangiogenesis and apoptosis

11. Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity.

12. Ndfip1 preserves Treg lineage stability and immune homeostasis by preventing the expansion of highly proliferative and metabolically active Treg cells and by preventing pathological secretion of IL-4 from Treg cells

13. IL-4/ STAT6 signaling needs to be well adjusted to ensure proper development and function of homing Th2 cells.

14. By establishing that IL-4 is posttranslationally regulated by TRX-promoted reduction of a disulfide bond, our findings highlight a novel regulatory mechanism of the type 2 immune response that is specific to IL-4 over IL-13.

15. The VEGFR1-mediated signaling suppressed IL-4-induced Arg-1 expression.

16. The results obtained in the present study suggest that a signaling pathway mediated by FcRg or the FcRg-Syk axis is commonly required for innate basophil IL-4 responses under conditions mimicking encounters with allergen sources.

17. IL-4Delta2 did not compete with IL-4 for IL-4Ralpha binding and did not interfere with the downstream STAT-6 phosphorylation in T cells.

18. this study shows that IL4 and IL21 cooperate to induce the high Bcl6 protein level required for germinal center formation

19. The complex role of IL-4 in autoimmunity and cholangitis.

20. The results demonstrate that IL-4 can restore insulin sensitivity in adipocytes via mechanisms not associated with induced adipogenesis or de novo formation of lipid depots.

Cow (Bovine) Interleukin 4 (IL4) Interaktionspartner

1. These results support pregnancy as type 2 immune response biased, with increases of IFN-gamma occurring after parturition and an increase in IL-4 production before calving.

2. IL-4 may play a role in coordinating the adrenal response to inflammatory stress.

3. T helper (Th) type 2 cell cytokine IL-4 modulates airway contraction by secreting matrix metalloproteinase-1 from the smooth muscle cells via phosphatidylinositol 3-kinase activation and changing cell-to-matrix interactions.

Pig (Porcine) Interleukin 4 (IL4) Interaktionspartner

1. IL-4- and IL-10-producing invariant NKT cells inhibit the Th1 cell response, but not the Th17 cell response

2. IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.

3. There was no significant difference of IL-4 production between fresh and frozen peripheral blood mononuclear cells.

4. The endothelium and subendothelium of porcine iliac arteries that are transduced with recombinant pig IL-4 are effectively protected from complement-dependent immediate injury after perfusion with human blood.

5. unlike in humans and mice, porcine IL-4 blocks antibody and IL-6 secretion and suppresses antigen-stimulated proliferation of B cells

Guinea Pig Interleukin 4 (IL4) Interaktionspartner

1. Data indicate that animals exposed to high lead concentration, the levels of IFNgamma and IFNgamma/IL-4 ratio were significantly lower than those exposed to its low concentration.

2. IL-4 and STAT6 are related to the pathogenesis of allergic rhinitis and may be the main factors for eosinophil infiltration in allergic rhinitis.

Horse (Equine) Interleukin 4 (IL4) Interaktionspartner

1. The data suggested in foals there is an impaired Th2 response, the immune response is Th1 biased, interferon-gamma production is qualitatively similar to adult horses, and regulatory IL-10 production by T cells is mature.

2. This study showed that pronounced lung eosinophilia in horses can be transient, abate without specific treatment, and in this instance, lack correlation to upregulation of expression of either IL-4 or IL-5.

Rhesus Monkey Interleukin 4 (IL4) Interaktionspartner

1. Low Sociable animals showed alterations in lymph node expression of the immunoregulatory cytokine genes IL4.

2. Mycobacterial infections of macaques induce mRNA encoding a variant IL-4 that functions as a growth factor to promote expansion of 4-hydroxy-3-methyl-but-2-enyl pyrophosphate-specific Vgamma2Vdelta2 T effector cells.