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CNOT2 promotes proliferation and angiogenesis via VEGF (zeige VEGFA Antikörper) signaling in MDA-MB-231 breast cancer cells.
ERG (zeige ERG Antikörper) is recruited to mRNAs via interaction with the RNA-binding protein (zeige PTBP1 Antikörper) RBPMS (zeige RBPMS Antikörper), and it promotes mRNA decay by binding CNOT2, a component of the CCR4 (zeige CCR4 Antikörper)-NOT deadenylation complex.
The CNOT2-CNOT3 (zeige CNOT3 Antikörper) heterodimer is stabilized and tightly anchored to the surface of CNOT1 (zeige CNOT1 Antikörper) through an unexpected intertwined arrangement of peptide regions lacking defined secondary structure.
Cnot1 (zeige CNOT1 Antikörper), Cnot2, and Cnot3 (zeige CNOT3 Antikörper) represent a novel component of the core self-renewal and pluripotency circuitry conserved in mouse and human ESCs (zeige NR2E3 Antikörper).
human CNOT2 is important for maintaining the deadenylase activity and structural integrity of the CCR4 (zeige CCR4 Antikörper)-NOT complex, thereby affecting cell viability.
This study shows that SMRT/NCoR (zeige NCOR1 Antikörper)-HDAC3 (zeige HDAC3 Antikörper) complex is a cofactor of CNOT2-mediated repression and suggests that transcriptional regulation by the Ccr4 (zeige CCR4 Antikörper)-Not complex involves regulation of chromatin modification.
major repression function of CNOT2 is localized in a specialized protein motif, the Not-Box
These findings suggest that CDK11 (zeige CDK11B Antikörper) may contribute to apoptosis by regulating the activity of NOT2 independent of its kinase activity.
These data have uncovered a novel role of core components of the Ccr4 (zeige CCR4 Antikörper)-Not complex as regulators of transition from partial to genuine induced pluripotent stem cells.
This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene.
CCR4-NOT transcription complex subunit 2
, CCR4-associated factor 2
, negative regulator of transcription 2
, CCR4-NOT transcription complex, subunit 2
, CCR4-NOT transcription complex subunit 2-like