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Human CEBPB Protein expressed in Wheat germ - ABIN1349085
Sasaki, Hashimoto, Sawa, Amaya: Tumor necrosis factor-alpha induces expression of C/EBP-beta in primary afferent neurons following nerve injury. in Neuroscience 2014
Nr1d1/Rev-erbalpha has a direct role in circadian clock regulation of autophagy, which also involves Cebpb/(C/ebpbeta) indirectly in zebrafish
We found that quercetin reduces the promoter activity of apoB, driven by the enforced expression of C/EBPb.
Chromatin immunoprecipitation analysis revealed that C/EBPbeta2 binds to multiple sites at the 5' promoter/regulatory region, introns, and the 3' untranslated region of the IGF-II gene.
C/EBPbeta down-regulated ERbeta expression through increasing its promoter methylation, and then regulated proliferation and apoptosis in prostate cancer
Data show that PPAR coactivator-1alpha (PGC1alpha) and CCAAT/enhancer binding protein beta (CEBPB) form a complex and bind to the promoter of carnitine palmitoyl transferase 1 A (CPT1A).
these results suggested that the activation of the expression of S100A8 induced by IL1a in TR146 epithelial cells involves a mechanism by which the binding activity of C/EBPB to the specific site (113/109) of the S100A8 promoter is increased
C/EBPbeta was involved in transcriptional regulation of UCA1 and contributed substantially to its high expression and proliferation promoting in bladder cancer cells.
our findings revealed that the C/EBPbeta-LINC01133 axis performs an oncogenic function in pancreatic ductal adenocarcinoma by activating CCNG1
As evaluated by ChIP, cultured lipopolysaccharide (LPS)-activated THP-1 cells incubated with l-arginine had significantly decreased IL1B transcription and reduced C/EBP-beta association with Spi1 on the IL1B promoter.
chromosome 19 miRNA cluster miRNAs and CEBPB might together determine the Triple negative breast cancers marker expression pattern.
CEBPbeta enhances platinum resistance of ovarian cancer cells by reprogramming H3K79 methylation.
Our data suggest that activation of the GPR91-ERK1/2-C/EBP beta (c-Fos, HIF-1a) signaling pathway plays a tonic role in regulating VEGF transcription in rat retinal ganglion cells.
C/EBPbeta contributes to all-trans retinoic acid-induced activation of NEAT1 during acute promyelocytic leukemia cell differentiation.
Palmitate can induce lipid accumulation in HepG2 cells by activating C/EBPbeta-mediated G0S2 expression.
Anti-tumor effect of Rg3, which is mediated by inhibition of C/EBPbeta/NF-kappaB signaling.
C/EBPbeta upregulation promoted tumor cell invasion in an MMP3-dependent manner in vitro and was associated with metastatic status in colorectal cancer
findings support the hypothesis that maternal diabetes-induced ER stress increases CHOP expression which represses PGC-1alpha through suppressing the C/EBPbeta transcriptional activity, subsequently induces mitochondrial dysfunction and ultimately results in NTDs
Studies indicate that CCAAT enhancer binding protein beta (C/EBPB)-transcription factor CITED4 (CITED4) signaling is a pathway in cardioprotection mediating benefits of exercise in heart.
C/EBP beta LAP isoform expression was increased and LIP/TNFAIP3/TNIP1 expression was decreased in systemic lupus erythematosus (SLE) patients. LAP expression was positively correlated with SLE disease activity; TNFAIP3 and TNIP1 expression was negatively correlated with SLE disease activity.
Overexpression of C/EBPbeta-1 increases transformation, upregulates expression of the cancer stem cell marker ALDH1A1, and leads to chemoresistance.
Elevated expression of CEBPB were associated with a decreased risk of hepatocellular carcinoma.
C/EBPbeta overexpression or knockdown did not change the levels of IL-1beta-induced SOCS1. SOCS1 regulated the levels of C/EBPbeta mRNA by ubiquitination of C/EBPbeta as well as transcriptional regulation in human chondrocytes.
C/EBPbeta suppresses miR-17-92 via two pathways - indirectly through induction of PU.1 expression, where it functions as an activator, and more efficiently, through direct interaction with the miR-17-92 promoter.
IL-17F promotes osteoblast differentiation independent of the canonical Wnt pathway and beta-catenin signaling.
Prep1 DR expands the DNA binding landscape of C/EBPb (CCAAT enhancer binding protein b) without affecting its expression or activation. The data indicate that Prep1 normally acts by restricting DNA binding of transcription factors to adipogenic enhancers, in particular C/EBPb.
Here, the authors describe that reduced C/EBPbeta-LIP expression due to genetic ablation of the short upstream open reading frame delays the development of age-associated phenotypes in mice. Moreover, female C/EBPbeta(DeltauORF) mice display an extended lifespan.
Endogenous C/EBPbeta and c-Jun stimulated a PR promoter-reporter and these two factors showed promoter occupancy on the endogenous PR gene.
Results show that C/ebpbeta inhibited myogenic differentiation and its expression was suppressed by miR-155.
Results suggest a mechanism by which expression of C/EBPalpha and PPARgamma is delayed via KLF10 expression and shed light on the negative feedback loop for C/EBPbeta-regulated adipogenesis in 3T3-L1 preadipocyte.
To gain further insight into the role of HBP1 in the MCE stage, we found that the HBP1 expression pattern is reciprocal to that of C/EBP, and ectopic expression of HBP1suppresses C/EBPbeta expression.
findings support that C/EBPbeta plays a pivotal role in AD pathogenesis via increasing delta-secretase expression
LCoR negatively regulates early adipogenesis by repressing C/EBP beta transcriptional activity and add LCoR to the growing list of transcriptional corepressors of adipogenesis.
results support a stimulatory effect of Pb on adipogenesis which involves ERK activation and C/EBPbeta upregulation prior to PPARgamma and adipogenesis activation.
Purple sweet potato colour, a class of naturally occurring anthocyanins, exhibited beneficial effects on hepatic steatosis, which were associated with blocking Src and C/EBPbeta activation.
Thus, this study identifies BCL11B as a novel regulator of adipogenesis, which works, at least in part, by stimulating C/EBPbeta activity and suppressing the Wnt/beta-catenin signaling pathway.
Study shows that alpha melanocyte stimulating hormone and forkhead box C2 protein promote fatty acid oxidation through C/EBPbeta negative transcription in mice adipose tissue.
The results indicated that miR-16 was transactivated by C/EBP-beta resulting in aggravated Ischemia-reperfusion induced acute kidney injury and that urinary miR-16 may serve as a potential biomarker for acute kidney injury.
These results suggest that C/EBPbeta is an endogenous initiator of neuropathic pain and could be a potential target for the prevention and treatment of this disorder.
We found that C/EBPbeta is phosphorylated by CK2 under AMPK suppression and ER stress, which are important from the viewpoint of the worsening pathological condition of type 2 diabetes, such as decreased insulin secretion and apoptosis of pancreatic beta cells.
the extracts dramatically attenuated the levels of adipogenic transcriptional factors, including CCAAT enhancer-binding protein alpha (C/EBPa), CCAAT enhancer-binding protein beta (C/EBPb), and gamma receptors by peroxisome proliferators (PPARg), during adipogenesis
Expression of the SENP2 gene was suppressed by theobromine. In vivo knockdown studies showed that AR1 knockdown in mice attenuated the anti-adipogenic effects of theobromine in younger mice. Theobromine suppresses adipocyte differentiation and induced C/EBPbeta degradation by increasing its sumoylation.
C/EBPbeta is a novel regulator of satellite cell self-renewal during muscle regeneration acting at least in part through Notch2.
The data suggest that the tumor suppressor activity of both RUNX1t1 and TFF1 are mechanistically connected to CEBPB and that cross-regulation between CEBPB-RUNX1t1-TFF1 plays an important role in gastric carcinogenesis.
C/EBP-beta plays a vital role in regulating GPR120 transcription.
The expression of porcine Prdx6 gene is up-regulated by C/EBPbeta and CREB.
Results show that expression changes of IGF1 genes were associated with C/EBP b expression during embryonic and postnatal development in porcine liver.
FoxO1 and C/EBPb regulate preadipocyte adipogenesis possibly through C/EBPb-> FoxO1-> C/EBPb feedback regulatory loop and FoxO1-C/EBPb protein complex.
the pig GPD1 gene is regulated negatively by C/EBP beta in cultured kidney cells
GATA-4 and C/EBPbeta are both required for FSH +/- IGF-I stimulation of the porcine steroidogenic acute regulatory protein gene promoter in homologous granulosa cell cultures.
The differential expression of specific CEBPA/B isoforms observed in maturing follicles and CL may contribute to changes in follicular cell differentiation and increasing steroidogenic capacity.
SREBP1a activated while C/EBP factors downregulated the activity of the SCD1 promoter.
These results indicate that the C/EBPbeta gene plays an important regulatory role in regulation of the cell cycle regulators and spermatogenesis-related genes expression and function of bovine SCs.
Suppression of CPT1B and induction of SCD and CEBPB by supplemental arginine promotes increased adiposity in Angus steers.
Co-culture of adipocytes and myoblasts elicited an increase in C/EBPbeta and PPAR-gamma gene expression in differentiated myoblasts and an increase in GPR43 gene expression in adipocytes.
Interaction of C/EBP-beta and NF-Y factors constrains activity levels of the nutritionally controlled promoter IA expressing the acetyl-CoA carboxylase-alpha gene in cattle.
The role of NF-kappaB and C/EBP factors in regulating basal and pathogen-induced expression of both genes from cattle, is investigated.
The 3' terminal end of the first intron of porcine SPP1 harbors a C/EBPbeta binding site and this binding site is negatively affected by the mutant G allele.
2-chloroethyl ethyl sulfide exposure caused a 2.3-fold increase in the activation of C/EBP accompanied with a 45% and 121% increase in the protein level of C/EBP beta and ICAM-1, respectively, and this effect was counteracted by the antioxidant liposome.
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene.
CCAAT/enhancer binding protein (C/EBP), beta
, CCAAT/enhancer-binding beta protein b
, CCAAT/enhancer-binding protein beta
, CCAAT/enhancer binding protein beta
, interleukin 6-dependent DNA-binding protein
, liver-enriched transcriptional activator protein
, nuclear factor NF-IL6
, nuclear factor of interleukin 6
, transcription factor 5
, C/EBP BETA
, interleukin-6-dependent-binding protein
, liver-enriched transcriptional activator
, nuclear protein Il6
, C/EBP beta
, c/EBP-related protein 2
, liver activating protein (LAP)
, nuclear factor-IL6
, silencer factor B
, c/EBP beta
, CCAAT box/enhancer binding protein beta
, CCR protein
, transcription factor NF-M