PLAUR Proteine (PLAUR)

Mouse (Murine) Plasminogen Activator, Urokinase Receptor (PLAUR) Interaktionspartner

1. The results establish GDE3 (zeige GDPD2 Proteine) as a negative regulator of the uPAR signaling network and, furthermore, highlight GPI (zeige GPI Proteine)-anchor hydrolysis as a cell-intrinsic mechanism to alter cell behavior.

2. The ratio of full-length versus cleaved uPAR as analysed by Western blotting and its regulation was assessed by addition of different protease inhibitors and transforming growth factor - beta1 (TGF-beta1 (zeige TGFB1 Proteine)). The role of uPAR cleavage in cell proliferation and migration was analysed using real-time cell analysis and invasion was assessed using the myoma invasion model

3. Plg-RKT is required for plasminogen (zeige PLG Proteine) binding and macrophage migration in vivo

4. The synergy of circulating factor suPAR and APOL1 (zeige APOL1 Proteine) G1 or G2 on alphavbeta3 integrin activation is a mechanism for CKD.

5. Results identify soluble uPAR as a functional connection between the bone marrow and the kidney, and they implicate bone marrow immature myeloid cells as a key source of soluble uPAR that leads to glomerular dysfunction.

6. Plaur deficiency does not increase susceptibility to epileptogenesis after traumatic brain injury in an animal model.

7. Significance of the urokinase-type plasminogen activator (zeige PLAU Proteine) and its receptor in the progression of focal segmental glomerulosclerosis in clinical and mouse models.

8. Findings indicate a significant correlation of uPAR cleavage with breast cancer progression, but the precise biological consequence(s) of the cleavage or the cleavage products still remains to be elucidated.

9. interaction of full-length suPAR with alphavbeta3 integrin expressed on podocytes results in down-modulation of nephrin (zeige NPHS1 Proteine) that may affect kidney functionality in different human pathologies characterized by increased concentration of suPAR.

10. In an in vivo murine angiogenesis model uPAR-deficient PTEN heterozygous animals increased the impaired angiogenic phenotype of uPAR knockout mice and were able to reverse the high invasive potential of PTEN heterozygotes.

Human Plasminogen Activator, Urokinase Receptor (PLAUR) Interaktionspartner

1. In acutely admitted patients with COPD (zeige ARCN1 Proteine), elevated PLAUR levels were associated with increased risk of mortality.

2. This study shows that the D2A sequence of the UPAR induces cell growth through alphaVbeta3 integrin and EGFR (zeige EGFR Proteine).

3. High expression of U-PAR is associated with breast cancer.

4. To develop enzyme-resistant analogues, we applied here the Retro-Inverso (RI) approach, whereby the topology of the side chains is maintained by inverting the sequence of the peptide and the chirality of all residues. Molecular dynamics suggests that peptide RI-3 adopts the turn structure typical of uPAR-FPR1 (zeige FPR1 Proteine) antagonists

5. results demonstrated that PLAUR induces geftinib-resistance through EGFR (zeige EGFR Proteine)/p-AKT (zeige AKT1 Proteine)/survivin signaling pathway in gefitinib-resistant human lung adenocarcinoma cells. PLAUR could be a novel therapeutic target for gefitinib-resistant NSCLC patients.

6. High Upar expression is associated with breast cancer.

7. Circulating soluble uPAR levels are higher in patients with peripheral arterial disease, particularly in those with extensive atherosclerosis and are predictive of long term cardiovascular and PAD-related outcomes.

8. Data confirmed PLAUR and CDH11, both targets of miR (zeige MLXIP Proteine)-335, to be overexpressed in gastric cancer tissues.

9. the present study demonstrated that EGF (zeige EGF Proteine) induced aggressiveness of gastric cancer cells by activating epithelial to mesenchymal transition, which involved the activation of the ERK1/2 pathway and, subsequently, uPAR expression

10. The results establish GDE3 (zeige GDPD2 Proteine) as a negative regulator of the uPAR signaling network and, furthermore, highlight GPI (zeige GNPDA1 Proteine)-anchor hydrolysis as a cell-intrinsic mechanism to alter cell behavior.

Cow (Bovine) Plasminogen Activator, Urokinase Receptor (PLAUR) Interaktionspartner

1. Data show that urokinase-type plasminogen activator (uPA (zeige PLAU Proteine)) is only expressed in the cumulus cells of immature and in vitro matured cumulus-oocyte complexes (COCs), while uPA (zeige PLAU Proteine) receptor (uPAR) and plasminogen activator inhibitor-1 (PAI-1 (zeige SERPINE1 Proteine)) are expressed in both the cumulus cells and the immature and in vitro matured oocytes.

2. uPA (zeige PLAU Proteine)/uPAR binding is involved in signaling pathways that activate transcription factors that regulate the synthesis of molecules concerned with the arrangement of a particular oviductal microenvironment.

3. Data indicate that superoxide dismutase (SOD) inhibited high glucose (HG)-induced expression of uPAR and VEGF in bovine retinal microvascular endothelial cell (REC).

4. These data indicated that E. coli LPS (zeige IRF6 Proteine) led to an increase in u-PA (zeige PLAU Proteine) activity and RNA expression of u-PA (zeige PLAU Proteine) and u-PAR in BME-UV1 cells, thus strengthening the role of the PA system during pathological processes.

5. the interaction between uPAR and Man-6-P/IGF2R (zeige IGF2R Proteine) is a low percentage binding event and that suPAR and full-length uPAR bind the Man-6-P/IGF2R (zeige IGF2R Proteine) by different mechanisms.