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anti-Human GHSR Antikörper:
anti-Mouse (Murine) GHSR Antikörper:
anti-Rat (Rattus) GHSR Antikörper:
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The effects of dietary energy on the metabolism of ghrelin (zeige GHRL Antikörper), leptin (zeige LEP Antikörper) and growth hormone secretagogue receptor in blood and tissues of steers are reported.
The coding regions of GHSR and SLC2A2 (zeige SLC2A2 Antikörper) were sequenced in 12 animals with extreme phenotypes for feed intake and gain; Sixteen SNPs were identified in SLC2A2 (zeige SLC2A2 Antikörper), and three were detected in GHSR.
provided conclusive evidence that the 19-TG allele of the 5'UTR (zeige UTS2R Antikörper) microsatellite of the bovine GHSR1a gene affects growth and carcass traits in Japanese Black cattle
We evaluated the haplotype variety and characterized the microsatellite ((TG)(n) , 5'-UTR (zeige UTS2R Antikörper)) and nucleotide polymorphisms of the bovine GHSR1a gene.
Ghrelin (zeige GHRL Antikörper) concentrations significantly decreased from pregnancy to 6 weeks postpartum and this change differed based on pregnancy depression status. Finally, ghrelin (zeige GHRL Antikörper) levels were lower in women who breastfed compared with women who were bottle-feeding.
it showed that the antinociception of ghrelin (zeige GHRL Antikörper) was correlated with the GHS-R1alpha and d-opioid receptors. Finally, the antinociception induced by deltorphin II wasn't blocked by the co-injection (i.c.v.) of [D-Lys (zeige LYZ Antikörper)(3)]-GHRP-6, indicating that the GHS-R1a isn't on the backward position of delta opioid receptor.
our results showed for the first time that the downregulation of GHSR1a by shRNA technology inhibits the growth of colorectal cancer cell line and xenograft tumor through upregulation of PTEN (zeige PTEN Antikörper) at transcription as well as translation levels.
GHSR mutations are associated with Obesity.
Results indicate that neuronal GHS-R is a crucial regulator of energy metabolism and a key mediator of DIO. Neuronal Ghsr deletion protects against DIO by regulating energy expenditure, not by energy intake. These novel findings suggest that suppressing central ghrelin (zeige GHRL Antikörper) signaling may serve as a unique antiobesity strategy.
Results suggest that the minor allele of the rs2948694 in the GHSR gene was associated with increased smoking possibly reflects an association with alcohol use disorder and nicotine dependence.
GHS-R1b (zeige HOXB7 Antikörper) not only determines the efficacy of ghrelin (zeige GHRL Antikörper)-induced GHS-R1a-mediated signaling but also determines the ability of GHS-R1a to form oligomeric complexes with other receptors.
The data indicates that GHSR hypermethylation is a pan (zeige SUPT6H Antikörper)-cancer marker regardless of the tissue from which the tumor originates.
the single nucleotide polymorphism of GHSR might be weaker association with cancer risk, especially with breast cancer risk
Data (including data from knockout mice) suggest ghrelin (zeige GHRL Antikörper) produced in pancreatic islets regulates insulin (zeige INS Antikörper) secretion and thereby regulates blood glucose; ghrelin (zeige GHRL Antikörper) signaling via growth hormone secretagogue-receptor appears to be involved. [REVIEW]
Fasting upregulates Fpn1 (zeige SLC40A1 Antikörper) expression in spleen and peritoneal macrophages, probably via a ghrelin (zeige GHRL Antikörper)/GHSR1a/MAPK (zeige MAPK1 Antikörper) signaling pathway.
our results suggest that AgRP (zeige AGRP Antikörper) neurons are key site for GHS-R mediated thermogenesis, and demonstrate that GHS-R in AgRP (zeige AGRP Antikörper) neurons plays crucial roles in governing energy utilization and pathogenesis of DIO.
Growth hormone secretagogue receptor (GHSR) deficiency suppresses smooth muscle cell (SMCs) numbers in in the neointima.
Studies demonstrate that ghrelin (zeige GHRL Antikörper) signaling has an important role in macrophage polarization and adipose tissue inflammation during aging.
Study demonstrated that NMDAR (zeige GRIN1 Antikörper) functions are regulated by ghrelin (zeige GHRL Antikörper) in a GHSR1a-dependent manner: NMDAR (zeige GRIN1 Antikörper)-mediated synaptic currents are increased as a result of GluN1 (zeige GRIN1 Antikörper) subunit phosphorylation in the hippocampal pyramidal neurons and synapses
Ghsr mediates the beneficial effects of Caloric restriction on enhancing adult hippocampal neurogenesis and memory.
Data show that chronic caloric restriction (CR) alters hypothalamic agouti-related protein (Agrp (zeige AGRP Antikörper)) and neuropeptide Y (Npy (zeige NPY Antikörper)) gene expression similarly in Ghrelin (zeige GHRL Antikörper)+/+, Ghrelin (zeige GHRL Antikörper)-/-, ghrelin receptor Ghsr+/+, and Ghsr-/- mice.
The expression of ghrelin (zeige GHRL Antikörper) and GH secretagogue receptor 1a [GHSR1a] in cerebral arteries and the effects of ghrelin (zeige GHRL Antikörper) analogs on cerebrovascular function are reproted.[GHSR1a]
Thus, GHSR1a differentially inhibits CaV2 (zeige CAV2 Antikörper) channels by Gi/o or Gq protein pathways depending on its mode of activation.
The results of this study indicated that ghrelin receptor signaling is not required for flavor preferences conditioned by the oral or post-oral actions of sugar and fat.
GHSR-1a is present in prepubertal pig ovary; no influence of GH on GHSR-1a expression is found.
This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein\; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin\; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.
, growth hormone secretagogue receptor type 1
, growth hormone secretagogue receptor
, ghrelin/growth hormone secretagogue receptor
, growth hormone secretagogue receptor type 1A
, growth hormone secretagogue receptor, type 1A
, growth hormone secretagogue receptor type 1-like
, GH-releasing peptide receptor
, G-protein coupled receptor
, growth hormone secretagogue receptor type 1b