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Variants of the COL5A1 gene seem to influence quadriceps muscle-tendon stiffness.
Both in cell lines and in mouse model, the extracellular matrix receptors including the integrin ( ITGA3 (zeige ITGA3 ELISA Kits) and ITGA2B), collagen ( COL5A1), and laminin ( LAMA5 (zeige LAMA5 ELISA Kits)) were significantly inhibited by curcumin at messenger RNA and protein levels.
Data suggest that, compared with obese white women, obese black women exhibit higher expression of HIF1A (hypoxia inducible factor 1 alpha (zeige HIF1A ELISA Kits)), COL5A1 (collagen Valpha1), and COL6A1 (zeige COL6A1 ELISA Kits) (collagen VIalpha1) in gluteal but not abdominal subcutaneous adipose tissue depots; up-regulation of expression of these proteins correlates with reduced insulin (zeige INS ELISA Kits) sensitivity in black women only.
COL5A1 mutation is associated with Adrenocortical Adenomas.
Gene expression levels of three randomly selected DEGs (zeige DEGS1 ELISA Kits), VCAN (zeige Vcan ELISA Kits), COL5A1 and KCNJ16 (zeige KCNJ16 ELISA Kits), were examined using RT-PCR in 10 ATC (zeige SRPK1 ELISA Kits) samples.. angiogenesis was activated by the high expression of CTHRC1 (zeige CTHRC1 ELISA Kits), VCAN (zeige Vcan ELISA Kits) and POSTN (zeige POSTN ELISA Kits), providing necessary nutrition for tumor cells
COL5A1 rs12722 was found to be associated with severity of musculoskeletal injuries but not with incidence of musculoskeletal injuries in top-level soccer players.
Data (including data from studies in knockout mice) suggest causative role for collagen(V)alpha1 hypersensitivity/autoimmunity in pathogenesis of atherosclerosis; both immune tolerance and reduction of plaque burden are dependent on interleukin 35.
Familial Ehlers-Danlos syndrome with lethal arterial events caused by a mutation in COL5A1 is described in a mother and her two sons, who all died at an early age from arterial ruptures.
Individuals with the BstUI A1 allele and DpnII B2 allele of the COL5A1 gene have a high likelihood of developing symptoms of the tennis elbow
In conclusion, the novel main finding of this study was a significant interaction between the COL5A1 rs12722 T/C and COL12A1 (zeige COL12A1 ELISA Kits) rs970547 A/G variants and risk of anterior cruciate ligament injury.
Significantly decreased fibroblast proliferation was observed in Col5a1(+/-) compared to Col5a1(+/+) fibroblasts.
Col5a1 knockout stroma demonstrated severe dysfunctional regulation of fibrillogenesis.
Sp7/Osterix (zeige SP7 ELISA Kits) was observed to participate in the activation of the Col5a1 promoter during osteoblast differentiation.
Col (zeige HDAC1 ELISA Kits)(V) is an established autoantigen in atherosclerotic mice, and Col (zeige HDAC1 ELISA Kits)(V) autoimmunity is a consistent feature, with variable T helper type (Th)1 (zeige TH1L ELISA Kits) cell pathway involvement.
analysis of processing of the Pro-alpha1(V)Pro-alpha2(V)Pro-alpha3(V (zeige COL5A3 ELISA Kits)) procollagen heterotrimer
CBF (zeige CEBPZ ELISA Kits) activated the Col5a1 promoter suggesting that CBF (zeige CEBPZ ELISA Kits) is a key factor in the coordinated expression of type I and V collagen genes
COL5A1 is regulated by TGF-beta (zeige TGFB1 ELISA Kits) in osteoblasts
col5a1 haploinsufficiency disrupts collagen fibril assembly at multiple stages
Type V collagen contributes to the development of functional connective tissues during embryogenesis.
This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II.
collagen alpha-1(V) chain
, collagen type 5 alpha 1
, procollagen alpha 1(V)
, alpha 1 (V) collagen
, alpha-1(V) collagen
, type V collagen
, collagen, type V, alpha 1
, alpha-1 type V collagen
, alpha1(V) collagen
, pro-alpha1(V) collagen
, procollagen type V alpha 1
, procollagen, type V, alpha 1
, collagen alpha 1 (V)