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Data suggest that Mg2+ or Mn2+ (but not Ca2+) induce a conformational change in inter-alpha-inhibitor (ITIH1 and ITIH2) and a bikunin/chondroitin sulfate-dependent increase in thermodynamic stability; bikunin binds adjacent to the two heavy chains.
Human inter-alpha-inhibitor is a substrate for factor XIIIa and tissue transglutaminase.
It forms complex with hyaluronan and the comlex is a functional molecule involved in inflammation.
TSG-6 acts as cofactor and catalyst in the production of IalphaI heavy chain x hyaluronan complexes
Leukocytes infiltrated to the synovium were strongly positive for hyaluronic acid, SHAP, and CD44 on their surfaces, suggesting a role for the adhesion-enhancing effect of SHAP in inflammation.
Increased levels of SHAP-HA complex in sera are possible predictive markers for cervical ripening in premature labor.
serum-derived hyaluronan-associated protein-hyaluronan complex has a role in progression of ovarian cancer
The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987
ITI heavy chain H2
, inter-alpha-inhibitor heavy chain 2
, inter-alpha-trypsin inhibitor heavy chain H2
, inter-alpha (globulin) inhibitor H2
, inter-alpha (globulin) inhibitor, H2 polypeptide
, inter-alpha-trypsin inhibitor complex component II
, serum-derived hyaluronan-associated protein
, inter-alpha globulin inhibitor H2 polypeptide
, inter-alpha-inhibitor heavy-chain H2
, Inter-alpha-inhibitor heavy chain 2