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Human Polyclonal Biglycan Primary Antibody für IHC, ELISA - ABIN188683
Antipova, Orgel: Non-enzymatic decomposition of collagen fibers by a biglycan antibody and a plausible mechanism for rheumatoid arthritis. in PLoS ONE 2012
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Human Polyclonal Biglycan Primary Antibody für IF (p), IHC (p) - ABIN872817
Huang, Zou, Shi, Zhang, Pen, Zhang, Gao, Wang: The effect of electroacupuncture on the extracellular matrix synthesis and degradation in a rabbit model of disc degeneration. in Evidence-based complementary and alternative medicine : eCAM 2014
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Human Polyclonal Biglycan Primary Antibody für IHC, IHC (p) - ABIN4284625
Van Bockstal, Lambein, Van Gele, De Vlieghere, Limame, Braems, Van den Broecke, Cocquyt, Denys, Bracke, Libbrecht, De Wever: Differential regulation of extracellular matrix protein expression in carcinoma-associated fibroblasts by TGF-β1 regulates cancer cell spreading but not adhesion. in Oncoscience 2015
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Human Polyclonal Biglycan Primary Antibody für WB - ABIN513714
Gasimli, Stansfield, Nairn, Liu, Paluh, Yang, Dordick, Moremen, Linhardt: Structural remodeling of proteoglycans upon retinoic acid-induced differentiation of NCCIT cells. in Glycoconjugate journal 2013
Human Monoclonal Biglycan Primary Antibody für IHC (p), IP - ABIN560056
Zhang, Lee, Young, Wang: The Small Leucine-Rich Proteoglycan BGN Accumulates in CADASIL and Binds to NOTCH3. in Translational stroke research 2015
Human Polyclonal Biglycan Primary Antibody für IHC, ELISA - ABIN334359
Chen, Lenschow, Tiede, Fischer, Kalthoff, Ungefroren: Smad4/DPC4-dependent regulation of biglycan gene expression by transforming growth factor-beta in pancreatic tumor cells. in The Journal of biological chemistry 2002
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TLR2 and BGN contribute to sterile inflammation and infertility in man.
Results show that Biglycan expression was upregulated by DNA demethylation in tumour endothelial cells from myeloma.
Elevated biglycan mRNA expression in adipose tissues of obese women
sex-specific allele combinations of BGN, COL5A1 (zeige COL5A1 Antikörper), and DCN (zeige DCN Antikörper), as well as eight miRNA recognition sequences, were associated with altered susceptibility to anterior cruciate ligament ruptures
high Bgn expression levels promote a more dense collagen architecture, leading to increased tissue stiffness. This increased tissue stiffness leads to higher integrin-beta1 expression on melanoma cells, which promotes their invasiveness.
The expression of hBGN in the skeletal muscle of the treated mice was 1.34-fold higher than that of the native mouse Bgn (mBgn). The low transduction efficiency and improved motor functions suggest that biglycan expressed in a small number of muscle fibers was likely to have been secreted and anchored to the cell surface throughout the whole muscular fibers
Results identified loss-of-function mutation in BGN gene in patients with an X-linked syndromic form of severe thoracic aortic aneurysms and dissections (TAAD) confirming BGN as causative gene in severe form of TAAD.
After the first year of smoking abstinence the levels of BGN expression and carotid-femoral pulse wave velocity are significantly improved as compared to baseline.
study reports a temporal relationship between altered placental biglycan expression and subsequent development of fetal growth restriction/small for gestational age.
Quantitative polymerase chain reaction for messenger RNA expression from tissue specimens revealed significantly higher expression of Biglycan (p = 0.0008) and Lumican (zeige LUM Antikörper) (p = 0.01) and lower expression of Decorin (zeige DCN Antikörper) (p < 0.0001) in urothelial carcinoma of bladder
A novel biological pathway has been discovered of soluble biglycan inducing HIF-2alpha (zeige EPAS1 Antikörper) protein stabilization and Epo (zeige EPO Antikörper) production presumably in an oxygen-independent manner, ultimately giving rise to secondary polycythemia.
Results show that Bgn plays a role in the process of angiogenesis during fracture healing, and that effect appears to be partially mediated through endostatin (zeige COL18A1 Antikörper) suppression.
Asporin (zeige ASPN Antikörper) deficiency changes skin glycosaminoglycan composition, and decorin (zeige DCN Antikörper) and biglycan content, which may explain the changes in skin mechanical properties.
Biglycan plays a protective role during the progression of atherosclerosis in ApoE (zeige APOE Antikörper)-deficient mice by inhibiting thrombin (zeige F2 Antikörper) generation.
These genes were concordantly induced by TAC (zeige IL2RA Antikörper) in WT but not in biglycan KO mice. CONCLUSIONS: Left ventricular pressure overload induces biglycan expression in cardiac fibroblasts. Ablation of biglycan improves cardiac function and attenuates left ventricular hypertrophy and fibrosis after long-term pressure overload.
Importance of biglycan and decorin (zeige DCN Antikörper) as targets for the manipulation of fetal membrane extracellular matrix stability in the context of inflammation.
Biglycan deficiency leads to loosely packed aortic collagen fibers, increased susceptibility of aortic elastin (zeige ELN Antikörper) fibers to angII-induced stress, and up-regulation of vascular perlecan (zeige HSPG2 Antikörper) content.
Biglycan signaling supported fetal membrane remodeling during early gestation in the absence of concomitant changes in TGFbeta (zeige TGFB1 Antikörper) levels.
Lumican (zeige LUM Antikörper) and biglycan influence corneal keratocyte lamellipodia organization and are critical in the regulation of stromal collagen fibrillogenesis.
Biglycan-triggered TLR-2- and TLR-4 (zeige TLR4 Antikörper)-signaling exacerbates the pathophysiology of ischemic acute kidney injury.
Data show that biglycan, collagen type I, collagen type II, decorin (zeige DCN Antikörper), and versican (zeige Vcan Antikörper) were significantly affected by vibration duration, frequency, and amplitude.
biglycan showed a unique ability to organize collagen VI into extensive hexagonal-like networks over a time period of only a few minutes
biglycan-induced fibroblast cytoskeletal and signalling changes result in an increased cell migration; potential role in the remodelling process
The results indicate that CTGF (zeige CTGF Antikörper) suppresses the synthesis of biglycan but newly induced that of decorin (zeige DCN Antikörper) in the cells when the cell density is low.
LDL electrostatic interactions with decorin (zeige DCN Antikörper) and biglycan in the aortic valve leaflets and vascular wall is a major source of LDL retention.
Bgn regulates BMP4 (zeige BMP4 Antikörper) signaling through modulation of Chordin (zeige CHRD Antikörper) anti-BMP4 (zeige BMP4 Antikörper) activity.
The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The encoded protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein plays a role in assembly of collagen fibrils and muscle regeneration. It interacts with several proteins involved in muscular dystrophy, including alpha-dystroglycan, alpha- and gamma-sarcoglycan and collagen VI, and it is critical for the assembly of the dystrophin-associated protein complex.
, bone/cartilage proteoglycan I
, bone/cartilage proteoglycan-I
, dermatan sulphate proteoglycan I
, small leucine-rich protein 1A
, Small proteoglycan I (biglycan), bone (BSPG1) (bone/cartilage proteclycan 1 precursor)
, bone/cartilage proteclycan 1
, leucine-rich PG I