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anti-Human FOSL2 Antikörper:
anti-Mouse (Murine) FOSL2 Antikörper:
anti-Rat (Rattus) FOSL2 Antikörper:
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Human Polyclonal FOSL2 Primary Antibody für IP - ABIN515798
Wrann, Eguchi, Bozec, Xu, Mikkelsen, Gimble, Nave, Wagner, Ong, Rosen: FOSL2 promotes leptin gene expression in human and mouse adipocytes. in The Journal of clinical investigation 2012
Data provide evidence that FOSL2 is the target gene of miR (zeige MLXIP Antikörper)-143 and negatively correlated with its expression. Down-regulation of FOSL2 seems to be a critical step in regulation of OS properties and the expression of miR (zeige MLXIP Antikörper)-143 can inhibit the proliferation, migration and invasion of OS by reducing the expression of FOSL2.
FOSL2 is a direct target of miR (zeige MLXIP Antikörper)-597 in breast cancer cells.
The binding and expression of c-Fos/Fra-2 increased as a function of severity of tongue lesions, yet selective participation of c-Jun appears to promote poor differentiation and aggressive tumorigenesis.
FOSL2 facilitates TGF-beta1 (zeige TGFB1 Antikörper)-induced migration by interaction with Smad3 (zeige SMAD3 Antikörper) in non-small cell lung cancer.FOSL2 positively regulates TGF-beta1 (zeige TGFB1 Antikörper) signalling .
FRA2 is a STAT5 (zeige STAT5A Antikörper) target gene regulated by IL-2 (zeige IL2 Antikörper) in human CD4 (zeige CD4 Antikörper) T cells.
we show that the suppression was mediated, at least in part, by a suspension culture-driven decrease in the levels of two members of the AP1 (zeige FOSB Antikörper) transcription factor complex, c-Jun (zeige JUN Antikörper) and Fra2
SOX4 is a direct target gene of FRA-2 and induces expression of HDAC8 (zeige HDAC8 Antikörper) in adult T-cell leukemia/lymphoma.
This study suggests that Fra-2 transgenic mice as an animal model of systemic sclerosis-associated pulmonary arterial hypertension display main characteristic features of the human disease.
results demonstrate the presence of a common oncogenic cascade initiated by FRA2/JUND (zeige JUND Antikörper) in CCR4 (zeige CCR4 Antikörper)-expressing mature T-cell malignancies such as ATLL and CTCLs
FOSL2 is a critical regulator of leptin (zeige LEP Antikörper) expression in adipocytes
Fra-2 overexpression might impair myofibroblast functions crucial for secondary septation
Data show that Fos-Related Antigen-2 (Fra-2) is a key upstream regulator of forkhead box O1 (Foxo1 (zeige FOXO1 Antikörper)) and interferon regulatory factor 4 (Irf4 (zeige IRF4 Antikörper)) expression and influences proliferation and differentiation of B cells at multiple stages.
Deletion of Fra-2 leads to increased PPARgamma2 (zeige PPARG Antikörper) expression and adipocyte differentiation as well as increased adipocyte apoptosis through upregulation of hypoxia-inducible factors.
Osteoblast-specific expression of Fra-2/AP-1 (zeige JUN Antikörper) controls adiponectin and osteocalcin (zeige BGLAP Antikörper) expression and affects metabolism.
Cytokine-mediated Fra-2 expression and stabilization is linked to regulation of myogenic progenitor cells.
AP-1 (zeige JUN Antikörper) composed with JunD (zeige JUND Antikörper) and Fra2 protein plays a primary role in enhancing the transcription level of the CD11c (zeige ITGAX Antikörper) gene in dendritic cells
Identify Fra-2 as an O(2)-sensitive transcriptional regulator of inducible TGFbeta (zeige TGFB1 Antikörper) expression and position Fra-2 as an important player in reoxygenation-induced myocardial fibrosis.
These findings reveal a novel function of Fra-2/AP-1 (zeige JUN Antikörper) as a positive regulator of bone and matrix formation in mice and humans.
Since transgenic overexpression of Fra-2 causes not only fibrosis but also vascular disease, Fra-2 might be an interesting novel candidate for molecular-targeted therapies for systemic sclerosis.
Fos-like antigen 2 (Fosl2), potentiates the rate of myocardial accretion from the zebrafish second heart field.
The Fos gene family consists of 4 members FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.
fos-related antigen 2
, FOS-like antigen 2
, phospholipase B1