anti-FOSL2 (FOSL2) Antikörper

Human FOS-Like Antigen 2 (FOSL2) Interaktionspartner

1. Fra-2 was significantly increased in kidney biopsies of lupus nephritis patients compared with healthy controls and other kidney disease in glomerular podocytes.

2. Results suggest that FOSL2 is a critical regulator of colorectal cancer metastasis.

3. there was a negative correlation between miR-133a and FOSL2 expression in Hepatocellular carcinoma samples.

4. this study indicates the existence of an aberrant miR-124-3p/Fra-2 pathway that results in glioma aggressiveness

5. Data provide evidence that FOSL2 is the target gene of miR-143 and negatively correlated with its expression. Down-regulation of FOSL2 seems to be a critical step in regulation of OS properties and the expression of miR-143 can inhibit the proliferation, migration and invasion of OS by reducing the expression of FOSL2.

6. FOSL2 is a direct target of miR-597 in breast cancer cells.

7. The binding and expression of c-Fos/Fra-2 increased as a function of severity of tongue lesions, yet selective participation of c-Jun appears to promote poor differentiation and aggressive tumorigenesis.

8. FOSL2 facilitates TGF-beta1-induced migration by interaction with Smad3 in non-small cell lung cancer.FOSL2 positively regulates TGF-beta1 signalling .

9. FRA2 is a STAT5 target gene regulated by IL-2 in human CD4 T cells.

10. we show that the suppression was mediated, at least in part, by a suspension culture-driven decrease in the levels of two members of the AP1 transcription factor complex, c-Jun and Fra2

11. SOX4 is a direct target gene of FRA-2 and induces expression of HDAC8 in adult T-cell leukemia/lymphoma.

12. This study suggests that Fra-2 transgenic mice as an animal model of systemic sclerosis-associated pulmonary arterial hypertension display main characteristic features of the human disease.

13. results demonstrate the presence of a common oncogenic cascade initiated by FRA2/JUND in CCR4-expressing mature T-cell malignancies such as ATLL and CTCLs

14. FOSL2 is a critical regulator of leptin expression in adipocytes

15. Results suggest that Fra-2 protein may be more effective than ATF-2 protein in cyst formation originated from epithelial cells of dental follicles.

16. These findings reveal a novel function of Fra-2/AP-1 as a positive regulator of bone and matrix formation in mice and humans.

17. Fra-2 is overexpressed in SSc and acts as a novel downstream mediator of the profibrotic effects of TGFbeta and PDGF.

18. Fra-2 overexpression is associated with a more aggressive tumor phenotype and is probably involved in breast cancer progression in vivo.

19. aberrantly expressed Fra-2 in association with JunD may play a major role in CCR4 expression and oncogenesis in adult T-cell leukemia.

20. FRA2 and AP1 have roles in development of pulmonary fibrosis

Mouse (Murine) FOS-Like Antigen 2 (FOSL2) Interaktionspartner

1. Fra-2 was expressed in the glomerular podocytes in a murine model of lupus. Fra2 knockdown enhanced the protein expression of nephrin.

2. this study shows that Fra2 overexpression in mice leads to non-allergic asthma development in an IL-13 dependent manner

3. Fra-2(Ob-tet) mice showed increased inflammatory responses.

4. Fra-2 overexpression might impair myofibroblast functions crucial for secondary septation

5. Data show that Fos-Related Antigen-2 (Fra-2) is a key upstream regulator of forkhead box O1 (Foxo1) and interferon regulatory factor 4 (Irf4) expression and influences proliferation and differentiation of B cells at multiple stages.

6. Deletion of Fra-2 leads to increased PPARgamma2 expression and adipocyte differentiation as well as increased adipocyte apoptosis through upregulation of hypoxia-inducible factors.

7. Osteoblast-specific expression of Fra-2/AP-1 controls adiponectin and osteocalcin expression and affects metabolism.

8. Cytokine-mediated Fra-2 expression and stabilization is linked to regulation of myogenic progenitor cells.

9. AP-1 composed with JunD and Fra2 protein plays a primary role in enhancing the transcription level of the CD11c gene in dendritic cells

10. FOSL2 is a critical regulator of leptin expression in adipocytes

11. Identify Fra-2 as an O(2)-sensitive transcriptional regulator of inducible TGFbeta expression and position Fra-2 as an important player in reoxygenation-induced myocardial fibrosis.

12. These findings reveal a novel function of Fra-2/AP-1 as a positive regulator of bone and matrix formation in mice and humans.

13. Since transgenic overexpression of Fra-2 causes not only fibrosis but also vascular disease, Fra-2 might be an interesting novel candidate for molecular-targeted therapies for systemic sclerosis.

14. AP-1 transrepressing retinoic acid does not deplete coactivators or AP-1 monomers but may target specific Jun or Fos containing dimers

15. Fra2 is a novel transcription factor important for skeletogenesis by affecting chondrocyte differentiation

16. MEKK1 regulates Fra-2 protein stability by inducing Fra-2 ubiquitination and degradation.

17. NFATc1 negatively regulates osteoblst differentiation by regulating fra-2

18. These data identify junD proto-oncogene (JunD) and Fos-related antigen 2 (Fra-2) as the activator protein-1 (AP-1) factors responsible for the RANKL-induced upregulation of the mouse Tcirg1 gene expression.

19. Fos-related protein Fra-2 controls osteoclast survival and size

20. FRA2 and AP1 have roles in development of pulmonary fibrosis

Zebrafish FOS-Like Antigen 2 (FOSL2) Interaktionspartner

1. Fos-like antigen 2 (Fosl2), potentiates the rate of myocardial accretion from the zebrafish second heart field.