Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
Human TGFB1 Protein expressed in CHO Cells - ABIN809732
Farges, Romeas, Melin, Pin, Lebecque, Lucchini, Bleicher, Magloire: TGF-beta1 induces accumulation of dendritic cells in the odontoblast layer. in Journal of dental research 2003
Show all 7 Pubmed References
Human TGFB1 Protein expressed in HEK-293T Cells - ABIN2039654
Munger, Harpel, Gleizes, Mazzieri, Nunes, Rifkin: Latent transforming growth factor-beta: structural features and mechanisms of activation. in Kidney international 1997
Show all 3 Pubmed References
Human TGFB1 Protein expressed in HEK-293T Cells - ABIN2039655
Loeys, Schwarze, Holm, Callewaert, Thomas, Pannu, De Backer, Oswald, Symoens, Manouvrier, Roberts, Faravelli, Greco, Pyeritz, Milewicz, Coucke, Cameron, Braverman, Byers, De Paepe, Dietz: Aneurysm syndromes caused by mutations in the TGF-beta receptor. in The New England journal of medicine 2006
Show all 3 Pubmed References
Human TGFB1 Protein expressed in HEK-293T Cells - ABIN2039656
Benke, Ágg, Szilveszter, Tarr, Nagy, Pólos, Daróczi, Merkely, Szabolcs: The role of transforming growth factor-beta in Marfan syndrome. in Cardiology journal 2013
Show all 3 Pubmed References
Human TGFB1 Protein expressed in HEK-293 Cells - ABIN805198
Huang, Zhao, Fields, Ransohoff, Zhou: Imatinib attenuates skeletal muscle dystrophy in mdx mice. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009
Show all 2 Pubmed References
Rat (Rattus) TGFB1 Protein expressed in Escherichia coli (E. coli) - ABIN1081012
Elfayomy, Almasry, El-Tarhouny, Eldomiaty: Human umbilical cord blood-mesenchymal stem cells transplantation renovates the ovarian surface epithelium in a rat model of premature ovarian failure: Possible direct and indirect effects. in Tissue & cell 2016
Rat (Rattus) TGFB1 Protein expressed in Human Cells - ABIN2009188
Assoian, Komoriya, Meyers, Miller, Sporn: Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization. in The Journal of biological chemistry 1983
Show all 4 Pubmed References
Human TGFB1 Protein expressed in HEK-293 Cells - ABIN2733505
Wang, Reece, Yang: Oxidative stress is responsible for maternal diabetes-impaired transforming growth factor beta signaling in the developing mouse heart. in American journal of obstetrics and gynecology 2015
TGF-beta1 regulated pAKT (zeige AKT1 Proteine) and IFNgamma expressions were associated with epithelial cell survival in rhesus macaque colon explants and suggest a potential role of mucosal TGF-beta1 in regulating intestinal homeostasis and EC integrity.
These findings suggest that FBLN5 (zeige FBLN5 Proteine) may interfere with choroidal neovascularization by downregulating VEGF (zeige VEGFA Proteine), CXCR4 (zeige CXCR4 Proteine), and TGFB1 expression and inhibiting choroidl endothelial cell proliferation.
SIV infection of rhesus macaques results in the emergence of IL-17 (zeige IL17A Proteine)-expressing cells during the acute phase. This subpopulation appears at day 14 postinfection concomitantly with an increase in TGF-beta and IL-18 (zeige IL18 Proteine) expression.
SIV-infected macaques exhibiting progression to AIDS displayed greater expression of TGF-beta and indoleamine 2,3 dioxygenase in CD8 (zeige CD8A Proteine)+ T cells from mesentric lymph nodes.
transforming growth factor beta (TGFbeta) is required for hematopoietic progenitor cell specification. The requirement for TGFbeta is two fold and sequential: autocrine via Tgfbeta1a and Tgfbeta1b produced in the endothelial cells themselves, followed by a paracrine input of Tgfbeta3 from the notochord, suggesting that the former programs the hemogenic endothelium and the latter drives endothelial-to-hematopoietic tran...
The fine tuning of TGF-beta signaling derives from positive and negative control by Ldb2a (zeige LDB2 Proteine).
TGFbeta1a regulates zebrafish posterior lateral line formation via Smad5 (zeige SMAD5 Proteine) mediated pathway.
PCSK7 (zeige PCSK7 Proteine) is essential for zebrafish development and regulates the expression and proteolytic cleavage of TGFbeta1a.
TGFbeta signaling orchestrates the beneficial interplay between scar-based repair and cardiomyocyte-based regeneration to achieve complete heart regeneration.
TGFbeta1 plays a role in zebrafish keratocyte migration.
data presented show that Zili suppresses TGF-beta signaling by physically associating with Smad4 (zeige SMAD4 Proteine) and preventing the formation of Smad2 (zeige SMAD2 Proteine)/3/4 and Smad1 (zeige SMAD1 Proteine)/5/9/4 complexes
TGF-beta1 acts at multiple sites, including LH receptor (zeige LHCGR Proteine), 20beta-HSD (zeige HAL Proteine) and membrane progestin receptor-beta (zeige PAQR8 Proteine), to inhibit zebrafish oocyte maturation
These data suggest Pez (zeige PTPN14 Proteine) plays a crucial role in organogenesis by inducing TGFbeta and epithelial-mesenchymal transition.
Data show that Rock2 (zeige ROCK2 Proteine) acts as a negative regulator of the TGFbeta signaling pathway.
These data indicate that TGF-beta signaling is crucial for the function of the transition zone, which in turn may affect the regulation of cilia length.
R-Smads are the key components of TGFbeta beta signals in germ layer induction. SCP3 (zeige SYCP3 Proteine) serves as a vegetally enriched, intrinsic factor (zeige GIF Proteine) to ensure a prepared status of Smads for their activation.
the present in vitro system, which permits not only the cell contraction-mediated cell sorting but also the TGF-b-directed mesodermal induction such as cartilage formation, may fairly reflect the embryogenesis in vivo.
Loss of XTgfbi impaired blastopore formation and dorsal tissue morphogenesis.
TGF-beta signaling has a role in nuclear localization of transcription factor Smad4 (zeige SMAD4 Proteine)
sortilin (zeige SORT1 Proteine) negatively regulates TGF-beta signaling by diverting trafficking of precursor proteins to the lysosome during transit through the biosynthetic pathway
Our findings indicate that TGF-beta signaling is a major determinant of EMT (zeige ITK Proteine) in T/E overexpressing LNCaP cells.
Data shows that ionizing radiation leads to direct DNA damage and generation of reactive oxygen species (ROS (zeige ROS1 Proteine)), with TGFbeta1 activation via ROS (zeige ROS1 Proteine), thrombin (zeige F2 Proteine) generation, platelet activation, and pro-inflammatory signaling promoting myofibroblast accumulation and ECM (zeige MMRN1 Proteine) production. Feed-forward loops, as TGFbeta1 promotes ROS (zeige ROS1 Proteine), amplify these profibrotic signals, and persistent low-grade inflammation insures their perpetuation. ...
rhTGF-beta1 affects sensitivity of human osteoblasts towards mechanical stimuli by damaging the microtubule structure of primary cilia in a HDAC6 (zeige HDAC6 Proteine)-dependent manner.
No significant association exists between TGF-beta1 +869T>C, and +915G>C and MDR1 C3435T gene polymorphisms and the pathogenesis of Cyclosporine A-induced Gingival Overgrowth in kidney transplant recipients.
FPPS (zeige FDPS Proteine) mediates TGF-beta1-induced lung cancer cell invasion and epithelial-to-mesenchymal transition via the RhoA (zeige RHOA Proteine)/Rock1 (zeige ROCK1 Proteine) pathway.
The results of this study demonstrate that the gene expression of MMP9 (zeige MMP9 Proteine), MMP12 (zeige MMP12 Proteine), TIMP1 (zeige TIMP1 Proteine) and TIMP2 (zeige TIMP2 Proteine) was influenced by the addition of TGF-beta1. These results may be translated to chronic venous insufficiency framework and suggest involvement of TGF-beta1 in the vein wall pathology.
our study demonstrates the potential role of proliferation to help understand the TGFbeta1 paradox. Patients with early-stage PDAC have longer median survival when TGFbeta1 expression is high, which may be due to limited cellular proliferation.
FN1 (zeige FN1 Proteine) fibrils regulate TGFB1-induced epithelial-mesenchymal transition.
The data suggest that reduced expression of E-cadherin (zeige CDH1 Proteine) and over-expression of Slug, Snail (zeige SNAI1 Proteine), and TGF-beta induce epithelial to mesenchymal transition in ameloblastoma.
These results demonstrate that short-term systemic administration of TGF-beta substantially prevents denervation-induced reduction of endochondral bone formation via stimulating endochondral differentiation.
Activated TGF-beta signaling rescued miR (zeige MYLIP Proteine)-143-reduced FSHR (zeige FSHR Proteine) and intracellular signaling molecules, and miR (zeige MYLIP Proteine)-143-induced porcine granulosa cell apoptosis.
TGF-beta1-induced epithelial-myofibroblast plasticity is FAK (zeige PTK2 Proteine)- dependent, whereas TGF-beta1-induced apoptosis is favored when FAK (zeige PTK2 Proteine) signaling is inhibited.
this study shows that TGF-beta1 protects intestinal integrity and influences Smad (zeige SMAD1 Proteine) and MAPK (zeige MAPK1 Proteine) signal pathways in intestinal epithelium cells after TNF-alpha (zeige TNF Proteine) challenge
this study shows that anemonin may ameliorate LPS (zeige IRF6 Proteine)-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR (zeige EGFR Proteine) signaling pathways
The results indicated that TGF-beta-1 was associated with the restoration of intestinal morphology and barrier function following weaning stress.
Data (including data from in vitro and in vivo experiments) suggest that day 14 elongated conceptus secretes proteins that up-regulate TGFbeta1 mRNA and TGFbeta1 expression in endometrium; TGFbeta1 may be important during pregnancy maintenance.
The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10 (zeige IL10 Proteine), and IL-6 (zeige IL6 Proteine) in ovarian follicles are reported.
Dietary (1,3/1,6)-beta-D-glucan reduced the mRNA expression of transforming growth factor (TGF) beta2 (zeige TGFB2 Proteine) and tended to reduce the mRNA expression of TGF-beta1 in lung tissue of neonatal piglet.
TGF-beta1, via TGF-beta1 receptor I and p38 MAPK (zeige MAPK14 Proteine) signaling, reduces CFTR (zeige CFTR Proteine) expression to impair CFTR (zeige CFTR Proteine)-mediated anion secretion, which would likely compound the effects associated with mild CFTR (zeige CFTR Proteine) mutations and ultimately would compromise male fertility.
High yield isolation of BMP-2 (zeige BMP2 Proteine) from bone and in vivo activity of a combination of BMP-2 (zeige BMP2 Proteine)/TGF-beta1.
hypoxia increased the expression of platelet-derived growth factor (PDGF (zeige PDGFA Proteine)) and transforming growth factor-beta1 (TGF-beta1) and decreased the expression of neprilysin (NEP (zeige MME Proteine)), which contributed to the hypoxia-induced Endothelial-to-mesenchymal transition of pulmonary artery endothelial cells.
TGF-beta1 modulates the expression of syndecan-4 (zeige SDC4 Proteine) in cultured vascular endothelial cells in a biphasic manner.
Taken together, Staphylococcus aureus induces TGF-beta1 and bFGF (zeige FGF2 Proteine) expression through the activation of AP-1 (zeige JUN Proteine) and NF-kappaB (zeige NFKB1 Proteine) in bovine mammary gland fibroblasts.
The results identify TGFB1 and ESRRA (zeige ESRRA Proteine) as likely transcriptional regulators of rumen epithelial development and energy metabolism, respectively, and provide targets for modulation of rumen development and function in the growing calf.
the combined treatment with TGF-beta1 and BMP-7 (zeige BMP7 Proteine) or treatment first with TGF-beta1 followed by BMP-7 (zeige BMP7 Proteine) was more effective than other treatment groups in both chondrogenic differentiation and SZP (zeige PRG4 Proteine) secretion.
Tenascin-X (zeige TNXB Proteine) promotes activation of latent TGF-beta1 and subsequent epithelial to mesenchymal transition in mammary epithelial cells.
a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1 (zeige SMAD1 Proteine)/5/8 and Smad2 (zeige SMAD2 Proteine)/3 channels through a negative feedback loop dependent on Smad7 (zeige SMAD7 Proteine).
Endogenous TGF-beta1 became more bioactive following activation of the transgene protein product in chondrocytes.
A novel peptide, P2K, regulating TGF-beta1 signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.
Data show that TGF-beta pathways operate during ovarian fetal development, and fibrillin 3 is highly expressed at a critical stage early in developing human and bovine fetal ovaries.
The present study describes the ability of color-coded intravital imaging to demonstrate the efficacy of a TGF-beta inhibitor to target stroma in an orthotopic mouse model of pancreatic cancer.The present study describes the ability of color-coded intravital imaging to demonstrate the efficacy of a TGF-beta inhibitor to target stroma in an orthotopic mouse model of pancreatic cancer.
The ratio of full-length versus cleaved uPAR (zeige PLAUR Proteine) as analysed by Western blotting and its regulation was assessed by addition of different protease inhibitors and transforming growth factor - beta1 (TGF-beta1). The role of uPAR (zeige PLAUR Proteine) cleavage in cell proliferation and migration was analysed using real-time cell analysis and invasion was assessed using the myoma invasion model
Hepatic Stellate Cells express iron-transport proteins. Holotransferrin (iron) activates HSC (zeige FUT1 Proteine) fibrogenesis and the TGF-beta pathway, whereas iron depletion by chelation reverses this, suggesting that this could be a useful adjunct therapy for patients with fibrosis.
The results show that lnc-Spry1 (zeige SPRY1 Proteine) could act as an early mediator of TGF-beta signaling and reveal different roles for a long noncoding RNA in modulating transcriptional and posttranscriptional gene expression.
TIMAP (zeige PPP1R16B Proteine) is suppressed by TGFbeta via HDAC3 (zeige HDAC3 Proteine)-associated Smad (zeige SMAD1 Proteine) signaling.
AMTN mRNA levels were induced at the initiation of apoptosis by TGFbeta1, which mediated through the Smad3 bindings to AMTN gene promoter.
these results demonstrated that endogenous tumor-derived TGF-beta aids in suppressing local anti-tumor immunity, resulting in tumor growth, whereas excess tumor-derived TGF-beta initially results in more rapid tumor proliferation and later growth suppression, independent of anti-tumor immunity
Results indicate that vimentin (zeige VIM Proteine) orchestrates the healing by controlling fibroblast proliferation, TGF-beta1-Slug signaling, and epithelial-mesenchymal transition (EMT (zeige ITK Proteine)) processing, and all of which in turn govern the required keratinocyte activation.
Dynamic expression and regulatory mechanism of TGF-beta signaling in chicken embryonic stem cells differentiating into spermatogonial stem cells
The results provide the first evidence that upregulation of TGFb/Smad3 (zeige SMAD3 Proteine) in injured arteries induces local smooth muscle cells CXCR4 (zeige CXCR4 Proteine) expression and cell migration, and consequently intimal hyperplasia.
Data indicate that cardiac contractility modulation (CCM) therapy exerted protective effects against myocardial fibrosis potentially by inhibiting TGF-beta1/Smad3 (zeige SMAD3 Proteine) signaling pathway in chronic heart failure .
study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.
cell therapy promoted TGF-beta1 expression in nucleus pulposus, leading to anti-inflammatory effects via the inhibition of NF-kappaB (zeige NFKB1 Proteine), and the amelioration of disc degradation.
that prenatal tracheal occlusion increases TGF-beta/Rho kinase (zeige ROCK1 Proteine) pathway, myofibroblast differentiation, and matrix deposition in neonatal rabbit and human congenital diaphragmatic hernia lungs
observation. Based on the above results, we conclude that TGF-beta1-immobilized PLGA-gelatin scaffold seeded with ASCs considerably enhances the quality of the tissue-engineered cartilage, therefore, advancing the field of cartilage tissue engineering
Smad7 (zeige SMAD7 Proteine) plays a crucial role in antagonizing epithelial-mesenchymal transition induced by TGFbeta signaling and is a Notch (zeige NOTCH1 Proteine) signaling target in limbal epithelial stem cells.
the role of IL-10 in inhibited allograft rejection may be associated with CD4+CD25+ regulatory T cells and IL-10, and may be independent of TGF-b
After NOTCH1 (zeige NOTCH1 Proteine) knockdown and TGFB1 stimulation, rabbit mesenchymal stem cells expressed higher levels of proteoglycan (zeige Vcan Proteine) and collagen II.
TGF-beta1 gene transcription significantly correlates with the surgical vaginal and dermal wound closure rate.
TGF beta is involved in the pathogenesis of tympanosclerosis.
There was significantly higher expression of TGF-beta1 and MMP-9 (zeige MMP9 Proteine) in nasal mucosa of experimental allergic rhinitis guinea pigs than in controls.
Within the limitations of the study design, production of COMP (zeige COMP Proteine) during healing of skin wounds does not appear to be influenced by wound type or anatomic site, nor does it appear to be correlated with TGF-beta1 concentrations.
Peritoneal TGF-beta(1) concentration was higher in horses with severe gastrointestinal diseases, in horses with an altered peritoneal fluid, and in nonsurvivors.
This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
transforming growth factor beta1
, transforming growth factor, beta 1
, transforming growth factor, beta-induced, 68kDa
, transforming growth factor-beta-induced protein ig-h3-like
, transforming growth factor beta-1-like
, transforming growth factor beta 4
, transforming growth factor beta-1
, TGF-beta 1 protein
, latency-associated peptide
, transforming growth factor, beta 1 (Camurati-Engelmann disease)
, transforming growth factor-beta-1
, TGF-beta 1
, transforming growth factor-beta 1
, transforming growth factor, beta-1
, transforming growth factor beta 1
, regulatory protein
, transforming growth factor-beta
, tgf beta
, tgf-beta 5
, transforming gorwth factor-Beta5
, transforming growth factor-B5
, transforming growth factor-beta 5
, Transforming growth factor beta-1