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Human TGFB1 Protein expressed in CHO Cells - ABIN809732
Farges, Romeas, Melin, Pin, Lebecque, Lucchini, Bleicher, Magloire: TGF-beta1 induces accumulation of dendritic cells in the odontoblast layer. in Journal of dental research 2003
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Human TGFB1 Protein expressed in HEK-293T Cells - ABIN2039656
Munger, Harpel, Gleizes, Mazzieri, Nunes, Rifkin: Latent transforming growth factor-beta: structural features and mechanisms of activation. in Kidney international 1997
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Human TGFB1 Protein expressed in HEK-293T Cells - ABIN2039657
Loeys, Schwarze, Holm, Callewaert, Thomas, Pannu, De Backer, Oswald, Symoens, Manouvrier, Roberts, Faravelli, Greco, Pyeritz, Milewicz, Coucke, Cameron, Braverman, Byers, De Paepe, Dietz: Aneurysm syndromes caused by mutations in the TGF-beta receptor. in The New England journal of medicine 2006
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Human TGFB1 Protein expressed in HEK-293T Cells - ABIN2039655
Benke, Ágg, Szilveszter, Tarr, Nagy, Pólos, Daróczi, Merkely, Szabolcs: The role of transforming growth factor-beta in Marfan syndrome. in Cardiology journal 2013
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Human TGFB1 Protein expressed in HEK-293 Cells - ABIN805198
Huang, Zhao, Fields, Ransohoff, Zhou: Imatinib attenuates skeletal muscle dystrophy in mdx mice. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009
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Rat (Rattus) TGFB1 Protein expressed in Escherichia coli (E. coli) - ABIN1081012
Elfayomy, Almasry, El-Tarhouny, Eldomiaty: Human umbilical cord blood-mesenchymal stem cells transplantation renovates the ovarian surface epithelium in a rat model of premature ovarian failure: Possible direct and indirect effects. in Tissue & cell 2016
Rat (Rattus) TGFB1 Protein expressed in Human Cells - ABIN2009188
Assoian, Komoriya, Meyers, Miller, Sporn: Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization. in The Journal of biological chemistry 1983
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Human TGFB1 Protein expressed in HEK-293 Cells - ABIN2733505
Wang, Reece, Yang: Oxidative stress is responsible for maternal diabetes-impaired transforming growth factor beta signaling in the developing mouse heart. in American journal of obstetrics and gynecology 2015
The present study demonstrated that in human osteoarthritis fibroblastlike synoviocytes, TGF-beta signals via p-Smad2 (zeige SMAD2 Proteine) and p-Smad1 (zeige GARS Proteine)/5/8. Furthermore, it was demonstrated that LTBP-1 (zeige LTBP1 Proteine) may modulate the activity of TGF-beta in human osteoarthritis fibroblastlike synoviocytes.
These data indicate that human amniotic epithelial cells (hAECs) endow potential anticancer properties on epithelial ovarian cancer in vivo and in vitro which is partially mediated by hAECsecreted TGFbeta1-induced cell cycle arrest. This study suggests a potential application of hAECbased therapy against epithelial ovarian cancer.
Results demonstrated that TGF-beta1 regulated FUT1 and Lewis y expression by activating the MAPK/c-Fos pathway.
analysis of how the molecular mechanisms involved in the dual response to TGF-beta in cancer, and how tumor cells evolve to evade the tumor-suppressive responses of this signaling pathway and then hijack the signal, converting it into an oncogenic factor [review]
The present study demonstrated that the expression of LKB1 (zeige STK11 Proteine) and SIK1 was downregulated, while TGF-beta and epithelialmesenchymal transition protein expression levels were upregulated in clinical ovarian tumor tissues and cells.
TGFB1 was shown to induce Epithelialtomesenchymal transition, thereby promoting the migration and invasion of HepG2 cells via JAK (zeige JAK3 Proteine)/STAT3 (zeige STAT3 Proteine)/Twist signaling.
Expression of TGF-beta was closely related to hypertrophy of the ligamentum flavum.
lasma levels of all TGF-beta isoforms were not altered in adolescent Chronic fatigue syndrome.
these results indicated that Bone marrow-derived mesenchymal stem cells -conditioned medium suppressed the epithelial-mesenchymal transition which might be associated with TGF-B1/Smad3 (zeige SMAD3 Proteine). This study provides the theoretical basis for the research of the mechanisms responsible for pulmonary disease.
we show that NORAD upregulates transforming growth factor-beta (TGF-beta) signaling and regulates TGF-beta-induced epithelial-to-mesenchymal transition (EMT (zeige ITK Proteine))-like phenotype
TGF-beta1 stimulated lubricin (zeige PRG4 Proteine) secretion by superficial zone chondrocytes at all densities with twice-a-week TGF-beta treatment. It is noteworthy that the daily treatment of TGF-beta1 increased lubricin (zeige PRG4 Proteine) much higher compared with twice-a-week treatment.
hypoxia increased the expression of platelet-derived growth factor (PDGF (zeige PDGFA Proteine)) and transforming growth factor-beta1 (TGF-beta1) and decreased the expression of neprilysin (NEP (zeige MME Proteine)), which contributed to the hypoxia-induced Endothelial-to-mesenchymal transition of pulmonary artery endothelial cells.
TGF-beta1 modulates the expression of syndecan-4 (zeige SDC4 Proteine) in cultured vascular endothelial cells in a biphasic manner.
Taken together, Staphylococcus aureus induces TGF-beta1 and bFGF (zeige FGF2 Proteine) expression through the activation of AP-1 (zeige JUN Proteine) and NF-kappaB (zeige NFKB1 Proteine) in bovine mammary gland fibroblasts.
The results identify TGFB1 and ESRRA (zeige ESRRA Proteine) as likely transcriptional regulators of rumen epithelial development and energy metabolism, respectively, and provide targets for modulation of rumen development and function in the growing calf.
the combined treatment with TGF-beta1 and BMP-7 (zeige BMP7 Proteine) or treatment first with TGF-beta1 followed by BMP-7 (zeige BMP7 Proteine) was more effective than other treatment groups in both chondrogenic differentiation and SZP (zeige PRG4 Proteine) secretion.
Tenascin-X (zeige TNXB Proteine) promotes activation of latent TGF-beta1 and subsequent epithelial to mesenchymal transition in mammary epithelial cells.
a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1 (zeige SMAD1 Proteine)/5/8 and Smad2 (zeige SMAD2 Proteine)/3 channels through a negative feedback loop dependent on Smad7 (zeige SMAD7 Proteine).
Endogenous TGF-beta1 became more bioactive following activation of the transgene protein product in chondrocytes.
A novel peptide, P2K, regulating TGF-beta1 signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.
Data indicate that cardiac contractility modulation (CCM) therapy exerted protective effects against myocardial fibrosis potentially by inhibiting TGF-beta1/Smad3 (zeige SMAD3 Proteine) signaling pathway in chronic heart failure .
study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.
cell therapy promoted TGF-beta1 expression in nucleus pulposus, leading to anti-inflammatory effects via the inhibition of NF-kappaB (zeige NFKB1 Proteine), and the amelioration of disc degradation.
that prenatal tracheal occlusion increases TGF-beta/Rho kinase (zeige ROCK1 Proteine) pathway, myofibroblast differentiation, and matrix deposition in neonatal rabbit and human congenital diaphragmatic hernia lungs
observation. Based on the above results, we conclude that TGF-beta1-immobilized PLGA-gelatin scaffold seeded with ASCs considerably enhances the quality of the tissue-engineered cartilage, therefore, advancing the field of cartilage tissue engineering
Smad7 (zeige SMAD7 Proteine) plays a crucial role in antagonizing epithelial-mesenchymal transition induced by TGFbeta signaling and is a Notch (zeige NOTCH1 Proteine) signaling target in limbal epithelial stem cells.
the role of IL-10 in inhibited allograft rejection may be associated with CD4+CD25+ regulatory T cells and IL-10, and may be independent of TGF-b
After NOTCH1 (zeige NOTCH1 Proteine) knockdown and TGFB1 stimulation, rabbit mesenchymal stem cells expressed higher levels of proteoglycan (zeige Vcan Proteine) and collagen II.
TGF-beta1 gene transcription significantly correlates with the surgical vaginal and dermal wound closure rate.
TGF beta is involved in the pathogenesis of tympanosclerosis.
There was significantly higher expression of TGF-beta1 and MMP-9 (zeige MMP9 Proteine) in nasal mucosa of experimental allergic rhinitis guinea pigs than in controls.
TGF-beta1 regulated pAKT (zeige AKT1 Proteine) and IFNgamma expressions were associated with epithelial cell survival in rhesus macaque colon explants and suggest a potential role of mucosal TGF-beta1 in regulating intestinal homeostasis and EC integrity.
SIV infection of rhesus macaques results in the emergence of IL-17 (zeige IL17A Proteine)-expressing cells during the acute phase. This subpopulation appears at day 14 postinfection concomitantly with an increase in TGF-beta and IL-18 (zeige IL18 Proteine) expression.
SIV-infected macaques exhibiting progression to AIDS displayed greater expression of TGF-beta and indoleamine 2,3 dioxygenase in CD8 (zeige CD8A Proteine)+ T cells from mesentric lymph nodes.
TGF-beta1 is activated or inactivated by MMP20 or KLK4 (zeige KLK4 Proteine) and that the amelogenin (zeige AMELX Proteine) cleavage product is necessary for the in-solution mobility of TGF-beta1.
Activated TGF-beta signaling rescued miR (zeige MYLIP Proteine)-143-reduced FSHR (zeige FSHR Proteine) and intracellular signaling molecules, and miR (zeige MYLIP Proteine)-143-induced porcine granulosa cell apoptosis.
TGF-beta1-induced epithelial-myofibroblast plasticity is FAK (zeige PTK2 Proteine)- dependent, whereas TGF-beta1-induced apoptosis is favored when FAK (zeige PTK2 Proteine) signaling is inhibited.
this study shows that TGF-beta1 protects intestinal integrity and influences Smad (zeige SMAD1 Proteine) and MAPK (zeige MAPK1 Proteine) signal pathways in intestinal epithelium cells after TNF-alpha (zeige TNF Proteine) challenge
this study shows that anemonin may ameliorate LPS (zeige IRF6 Proteine)-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR (zeige EGFR Proteine) signaling pathways
The results indicated that TGF-beta-1 was associated with the restoration of intestinal morphology and barrier function following weaning stress.
Data (including data from in vitro and in vivo experiments) suggest that day 14 elongated conceptus secretes proteins that up-regulate TGFbeta1 mRNA and TGFbeta1 expression in endometrium; TGFbeta1 may be important during pregnancy maintenance.
The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10 (zeige IL10 Proteine), and IL-6 (zeige IL6 Proteine) in ovarian follicles are reported.
Dietary (1,3/1,6)-beta-D-glucan reduced the mRNA expression of transforming growth factor (TGF) beta2 (zeige TGFB2 Proteine) and tended to reduce the mRNA expression of TGF-beta1 in lung tissue of neonatal piglet.
TGF-beta1, via TGF-beta1 receptor I and p38 MAPK (zeige MAPK14 Proteine) signaling, reduces CFTR (zeige CFTR Proteine) expression to impair CFTR (zeige CFTR Proteine)-mediated anion secretion, which would likely compound the effects associated with mild CFTR (zeige CFTR Proteine) mutations and ultimately would compromise male fertility.
These data indicate that TGF-beta signaling is crucial for the function of the transition zone, which in turn may affect the regulation of cilia length.
R-Smads are the key components of TGFbeta beta signals in germ layer induction. SCP3 (zeige SYCP3 Proteine) serves as a vegetally enriched, intrinsic factor (zeige GIF Proteine) to ensure a prepared status of Smads for their activation.
the present in vitro system, which permits not only the cell contraction-mediated cell sorting but also the TGF-b-directed mesodermal induction such as cartilage formation, may fairly reflect the embryogenesis in vivo.
Loss of XTgfbi impaired blastopore formation and dorsal tissue morphogenesis.
TGF-beta signaling has a role in nuclear localization of transcription factor Smad4 (zeige SMAD4 Proteine)
sortilin (zeige SORT1 Proteine) negatively regulates TGF-beta signaling by diverting trafficking of precursor proteins to the lysosome during transit through the biosynthetic pathway
Within the limitations of the study design, production of COMP (zeige COMP Proteine) during healing of skin wounds does not appear to be influenced by wound type or anatomic site, nor does it appear to be correlated with TGF-beta1 concentrations.
Peritoneal TGF-beta(1) concentration was higher in horses with severe gastrointestinal diseases, in horses with an altered peritoneal fluid, and in nonsurvivors.
In obese mice, periodontitis caused the downregulation of MMP2 (zeige MMP2 Proteine), and upregulation of TIMP1 (zeige TIMP1 Proteine) and TGF-beta1 at transcriptional and translational levels
The protective effect of the EP2 receptor on TGF-beta1 induced podocyte injury via the PI3K / Akt (zeige AKT1 Proteine) signaling pathway.
This study demonstrates that prevention of renal apoB (zeige APOB Proteine) accumulation is a mechanism by which TGF-beta inhibition is nephroprotective.
data show that increased TGFbeta in the tumour microenvironment represents a primary mechanism of immune evasion that promotes T-cell exclusion and blocks acquisition of the TH1 (zeige HAND1 Proteine)-effector phenotype; immunotherapies directed against TGFbeta signalling may therefore have broad applications in treating patients with advanced colorectal cancer
IL 6 (zeige IL6 Proteine) and TGF beta perform essential role in cerebral malaria pathogenesis by modulating the level of glial cell induced neuroinflammation.
The increased susceptibility to IMQ-induced psoriasis of GILZ (zeige TSC22D3 Proteine)-Tg mice was significantly associated with skin-specific over-activation of TGF-beta1-mediated signaling via SMAD2 (zeige SMAD2 Proteine)/3.
The data suggest that B cells can down-regulate the function of antigen-presenting cells, and in turn encephalitogenic Th1 (zeige HAND1 Proteine)/Th17 responses, via TGF-beta1.
p-SMAD2 (zeige SMAD2 Proteine)/3 and p-ERK1/2 might play a regulatory role in TGF-beta1 induced CTGF (zeige CTGF Proteine) exp p-SMAD2 (zeige SMAD2 Proteine)/3 and p-ERK1/2 might play a regulatory role in TGF-beta1 induced CTGF (zeige CTGF Proteine) expression during tooth development.
inhibiting NCAM1 (zeige NCAM1 Proteine) would be cardioprotective, counteract the pathological action of TGFbeta1 and reduce heart failure severity.
TGF-beta signaling has a role in inhibiting tumor progression and invasion in an induced mouse bladder cancer model
transforming growth factor beta (TGFbeta) is required for hematopoietic progenitor cell specification. The requirement for TGFbeta is two fold and sequential: autocrine via Tgfbeta1a and Tgfbeta1b produced in the endothelial cells themselves, followed by a paracrine input of Tgfbeta3 from the notochord, suggesting that the former programs the hemogenic endothelium and the latter drives endothelial-to-hematopoietic tran...
The fine tuning of TGF-beta signaling derives from positive and negative control by Ldb2a (zeige LDB2 Proteine).
TGFbeta1a regulates zebrafish posterior lateral line formation via Smad5 (zeige SMAD5 Proteine) mediated pathway.
PCSK7 (zeige PCSK7 Proteine) is essential for zebrafish development and regulates the expression and proteolytic cleavage of TGFbeta1a.
TGFbeta signaling orchestrates the beneficial interplay between scar-based repair and cardiomyocyte-based regeneration to achieve complete heart regeneration.
TGFbeta1 plays a role in zebrafish keratocyte migration.
data presented show that Zili suppresses TGF-beta signaling by physically associating with Smad4 (zeige SMAD4 Proteine) and preventing the formation of Smad2 (zeige SMAD2 Proteine)/3/4 and Smad1 (zeige SMAD1 Proteine)/5/9/4 complexes
TGF-beta1 acts at multiple sites, including LH receptor (zeige LHCGR Proteine), 20beta-HSD (zeige HAL Proteine) and membrane progestin receptor-beta (zeige PAQR8 Proteine), to inhibit zebrafish oocyte maturation
These data suggest Pez (zeige PTPN14 Proteine) plays a crucial role in organogenesis by inducing TGFbeta and epithelial-mesenchymal transition.
Data show that Rock2 (zeige ROCK2 Proteine) acts as a negative regulator of the TGFbeta signaling pathway.
This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
TGF-beta 1 protein
, latency-associated peptide
, transforming growth factor beta-1
, transforming growth factor, beta 1 (Camurati-Engelmann disease)
, transforming growth factor-beta 1
, transforming growth factor beta 1
, transforming growth factor-beta
, transforming growth factor beta1
, transforming growth factor-beta-1
, tgf beta
, tgf-beta 5
, transforming gorwth factor-Beta5
, transforming growth factor-B5
, transforming growth factor-beta 5
, TGF-beta 1
, regulatory protein
, transforming growth factor, beta-1
, transforming growth factor, beta 1
, transforming growth factor, beta-induced, 68kDa
, transforming growth factor beta-1-like
, transforming growth factor beta 4
, TGF beta