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Although the expression of SPRY1 was low when compared with other tumors, SPRY1 was variably expressed in primary Ewing sarcoma tumors and higher expression levels were significantly associated with improved outcome in a large patient cohort.
SPRY1 and SPRY2 (zeige SPRY2 Proteine) mRNA transcripts were significantly upregulated in human CRC (zeige CALR Proteine). Suppression of SPRY2 (zeige SPRY2 Proteine) repressed AKT2 (zeige AKT2 Proteine) and EMT (zeige ITK Proteine)-inducing transcription factors and significantly increased E-cadherin (zeige CDH1 Proteine) expression. Concurrent downregulation of SPRY1 and SPRY2 (zeige SPRY2 Proteine) also increased E-cadherin (zeige CDH1 Proteine) and suppressed mesenchymal markers in colon cancer cells.
Spry1 plays a selective role in at least a subset of triple-negative breast cancer to promote the malignant phenotype via enhancing EGF (zeige EGF Proteine)-mediated mesenchymal phenotype.
Suppression of SPRY1 by age-associated methylation inhibits the replenishment of the muscle stem cell pool.
Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer
There is an inverse correlation between the expression of Spry1 and growth, proliferation, invasion and migration of ovarian cancer cells.
A random population of LNCaP prostate cancer cells comprises a heterogeneous group of cells with different androgen-deprivation sensitivities and potential for invasiveness; expression levels of 2 genes known to be regulated by miR (zeige MLXIP Proteine)-21, an androgen-regulated microRNA, SPRY1 and JAG1 (zeige JAG1 Proteine) were lower in an androgen insensitive clone, than an androgen sensitive clone.
The Spry1 acts as a sensor of mitogenic activity that not only attenuates RTK signaling but also induces a cellular senescence response to avoid uncontrolled proliferation.
Spry1 and Spry4 have opposing roles in VSMC phenotypic modulation, and Spry1 maintains the VSMC differentiation phenotype in vitro in part through an Akt/FoxO/myocardin pathway.
Re-expression of SPRY1, a repressed target of BCL11B, limits the transformation capacity of Ewing sarcoma cells.
The results show that lnc-Spry1 could act as an early mediator of TGF-beta (zeige TGFB1 Proteine) signaling and reveal different roles for a long noncoding RNA in modulating transcriptional and posttranscriptional gene expression.
modulation of stromal paracrine signaling and extracellular matrix remodeling by SPRY1 regulates mammary epithelial morphogenesis during postnatal development.
Here, we present a novel mouse model of pheochromocytoma consisting of double-heterozygous mice for Pten and Sprouty1 (Spry1), which leads to pheochromocytomas that appear at earlier onset and grow at a higher rate than those from Pten+/- mice.
Sprouty gain of function disrupts lens cellular processes and growth by restricting receptor tyrosine kinase (zeige ERBB3 Proteine) signaling.
In vivo analysis of thyroid glands from Spry1 knockout mice reveals that Spry1 induces a senescence-associated secretory phenotype via activation of the NFkappaB pathway.
showed that hSpry1 overexpression prevents VEGF secretion
Spry1 and Spry2 (zeige SPRY2 Proteine) coordination is required for normal development of the external genitalia in mice
conjunctival epithelial Spry1 and Spry2 (zeige SPRY2 Proteine) redundantly promote eyelid closure.
Findings demonstrate that Pokemon (zeige ZBTB7A Proteine) suppresses Sprouty1 expression through a miR (zeige MLXIP Proteine)-21-mediated mechanism, affecting the growth and proliferation of liver cancer cells.
May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
protein sprouty homolog 1
, sprouty, Drosophila, homolog of, 1 (antagonist of FGF signaling)
, sprouty 1 protein
, sprouty homolog 1, antagonist of FGF signaling (Drosophila)
, sprouty homolog 1, antagonist of FGF signaling
, sprouty 1
, sprouty homolog 1a, antagonist of FGF signaling
, sprouty homolog 1b, antagonist of FGF signaling
, inhibitor of receptor tyrosine kinases