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Study demonstrated that Spry1 has a role in supporting mitogen-induced vascular hyperplasia, at least in part by promoting Akt (zeige AKT1 Proteine)/Rb signaling and increasing mitogen-induced cyclinD1 expression and decreasing p27Kip1 (zeige CDKN1B Proteine) expression.
SPRY1 maybe a negative feedback regulator in normal human epidermal keratinocytes.
FREM2 is thus proposed as a novel GB biomarker and a putative biomarker of glioblastoma stem cells. Both FREM2 and SPRY1 are expressed on the surface of the GB cells, while SPRY1 alone was found overexpressed in the cytosol of non-malignant astrocytes.
Inhibition of miR (zeige MLXIP Proteine)-29b could attenuate atherosclerosis by inhibiting the SPRY1/MAPK (zeige MAPK1 Proteine) signaling pathway and inflammation in aorta.
During adipogenesis and osteogenesis, TNF-alpha (zeige TNF Proteine) significantly increased Spry1 levels and overexpression of miR (zeige MLXIP Proteine)-21 dramatically decreased Spry1 levels in the presence of TNF-alpha (zeige TNF Proteine), indicated important roles of miR (zeige MLXIP Proteine)-21 in modulating link between TNF-alpha (zeige TNF Proteine) and Spry1. Our findings introduce a molecular mechanism in which TNF-alpha (zeige TNF Proteine) suppresses adipogenic and osteogenic differentiation of PDLSCs by inhibiting miR (zeige MLXIP Proteine)-21/Spry1 func...
Although the expression of SPRY1 was low when compared with other tumors, SPRY1 was variably expressed in primary Ewing sarcoma tumors and higher expression levels were significantly associated with improved outcome in a large patient cohort.
SPRY1 and SPRY2 (zeige SPRY2 Proteine) mRNA transcripts were significantly upregulated in human CRC (zeige CALR Proteine). Suppression of SPRY2 (zeige SPRY2 Proteine) repressed AKT2 (zeige AKT2 Proteine) and EMT (zeige ITK Proteine)-inducing transcription factors and significantly increased E-cadherin (zeige CDH1 Proteine) expression. Concurrent downregulation of SPRY1 and SPRY2 (zeige SPRY2 Proteine) also increased E-cadherin (zeige CDH1 Proteine) and suppressed mesenchymal markers in colon cancer cells.
Spry1 plays a selective role in at least a subset of triple-negative breast cancer to promote the malignant phenotype via enhancing EGF (zeige EGF Proteine)-mediated mesenchymal phenotype.
Suppression of SPRY1 by age-associated methylation inhibits the replenishment of the muscle stem cell pool.
Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer
Loss of Spry1/2 enhances the survival of effector CD8 (zeige CD8A Proteine)+ T cells and results in the formation of more protective memory cells. Deleting Spry1/2 in antigen-specific CD8 (zeige CD8A Proteine)+ T cells may have therapeutic potential for enhancing the survival and functionality of effector and memory CD8 (zeige CD8A Proteine)+ T cells in vivo.
The results show that lnc-Spry1 could act as an early mediator of TGF-beta (zeige TGFB1 Proteine) signaling and reveal different roles for a long noncoding RNA in modulating transcriptional and posttranscriptional gene expression.
modulation of stromal paracrine signaling and extracellular matrix remodeling by SPRY1 regulates mammary epithelial morphogenesis during postnatal development.
Here, we present a novel mouse model of pheochromocytoma consisting of double-heterozygous mice for Pten and Sprouty1 (Spry1), which leads to pheochromocytomas that appear at earlier onset and grow at a higher rate than those from Pten+/- mice.
Sprouty gain of function disrupts lens cellular processes and growth by restricting receptor tyrosine kinase (zeige ERBB3 Proteine) signaling.
In vivo analysis of thyroid glands from Spry1 knockout mice reveals that Spry1 induces a senescence-associated secretory phenotype via activation of the NFkappaB pathway.
showed that hSpry1 overexpression prevents VEGF (zeige VEGFA Proteine) secretion
May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
protein sprouty homolog 1
, sprouty, Drosophila, homolog of, 1 (antagonist of FGF signaling)
, sprouty 1 protein
, sprouty homolog 1, antagonist of FGF signaling (Drosophila)
, sprouty homolog 1, antagonist of FGF signaling
, sprouty 1
, sprouty homolog 1a, antagonist of FGF signaling
, sprouty homolog 1b, antagonist of FGF signaling
, inhibitor of receptor tyrosine kinases