REPS2 Proteine (REPS2)

Human RALBP1 Associated Eps Domain Containing Protein 2 (REPS2) Interaktionspartner

1. HIV-1 gp41 promotes viral endocytosis in a CD4-independent manner by interacting with the host protein POB1.

2. miR-675-5p might play an oncogenic role in esophageal squamous cell carcinoma (ESCC) through RalBP1/RAC1/CDC42 signaling pathway by inhibiting REPS2 and might serve as a valuable prognostic biomarker and therapeutic target for ESCC patients.

3. downregulation of REPS2 may contribute to malignant progression of esophageal squamous cell carcinoma and represent a novel prognostic marker and a potential therapeutic target for esophageal squamous cell carcinoma patients.

4. These results suggest that POB1 interacts with PAG2 through its proline-rich motif, thereby regulating cell migration.

5. POB1, through its influence on the Ral signalling pathway, is involved in growth factor signalling and consequently in control of cell proliferation

6. decreased expression of REPS2 might be a key factor, causing prostate cancer cells to become resistant to induction of apoptosis by androgen deprivation.

7. Decreased REPS2 expression is associated with androgen-independent state of advanced prostate cancer

8. These results show for the first time that POB1 can regulate the transport function of RLIP76 and are consistent with our previous studies showing that inhibition of RLIP76 induces apoptosis in cancer cells.

9. Hsf-1 causes specific and saturable inhibition of the transport activity of Ralbp1 and that the combination of Hsf-1 and POB1 causes nearly complete inhibition through specific bindings with Ralbp1.

10. REPS2 may be a useful tumor marker for favorable prognosis in breast cancer.