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Data suggests that SNPs in PTPN2/22 affect the negative regulation of the immune response in Crohn's disease patients, thus leading to an increase in inflammation/apoptosis and susceptibility of mycobacteria.
the molecular mechanisms by which PTP1B (zeige PTPN1 Proteine) and TC-PTP loss co-operates with other genetic aberrations will need to be elucidated to design more effective therapeutic strategies.
In summary, we demonstrate that TCPTP protects the intestinal epithelial barrier by restricting STAT (zeige STAT1 Proteine)-induced claudin-2 (zeige CLDN2 Proteine) expression.
PASD1 (zeige PASD1 Proteine) serves as a critical nuclear positive regulator of STAT3 (zeige STAT3 Proteine)-mediated gene expression and tumorigenesis.
reported that SNPs in STAT4 (zeige STAT4 Proteine), PTPN2, PSORS1C1 (zeige PSORS1C1 Proteine), and TRAF3IP2 (zeige TRAF3IP2 Proteine) are associated with response to TNF (zeige TNF Proteine)-i treatment in RA patients; however, these findings should be validated in a larger population
The results suggest that miR (zeige MLXIP Proteine)-448 might promote Th17 differentiation in multiple sclerosis and thus aggravate the disease through inhibiting PTPN2.
ACPA (zeige PRTN3 Proteine) were associated significantly with rs7574865 in STAT-4 (zeige STAT4 Proteine). The SNP rs2233945 in the PSORS1C1 (zeige PSORS1C1 Proteine) gene was protective regarding the presence of bone erosions, while rs2542151 in PTPN2 gene was associated with joint damage.
Inflammatory bowel disease patients carrying the C-allele of PTPN2 SNP rs1893217 are at greater risk for developing a severe disease course but are more likely to respond to treatment with anti-TNF (zeige TNF Proteine) antibodies.
The increase in miR (zeige MLXIP Proteine)-210 resulted in down regulation of its target PTPN2 mRNA in pre-eclampsia.
role of PTPN2 in type 1 diabetes and Crohn's disease (review)
TCPTP controls Insulin resistance signaling in AgRP neurons to coordinate hepatic glucose production and brown/beige adipocyte glucose uptake in response to feeding/fasting.
PTPN2 overexpression in white adipose tissue could significantly reduce macrophages infiltration, the ratio of M1/M2 macrophages and the expression of pro-inflammatory cytokines in white adipose tissue , improving insulin (zeige INS Proteine) resistance.
Data suggest that interaction of Ppard (zeige PPARD Proteine) with Tcptp45 blunts insulin (zeige INS Proteine) resistance and leads to retention of Tcptp45 in nucleus of hepatocytes, myotubes, and adipocytes; alteration of such interactions may be involved in insulin (zeige INS Proteine) resistance observed in obesity. (Ppard (zeige PPARD Proteine) = peroxisome proliferator activator receptor delta (zeige PPARD Proteine); Tcptp45 = protein tyrosine phosphatase non-receptor type 2 [Ptpn2], 45kDa (zeige NFE2 Proteine) alternative splicing variant)
These results indicate that deficiencies in PTPN2 across multiple immune lineages, including naive T cells, Tfh cells and B cells, contribute to the development of autoimmunity.
PTPN2 is a positive regulator of lipopolysaccharide-induced inflammatory response by enhancing the activity of Src (zeige SRC Proteine) through targeting the inhibitory phosphor-tyrosine527 of Src (zeige SRC Proteine).
Loss of PTPN2 in intestinal epithelial cells has no significant influence on inflammation in dextran sulphate sodium-induced colitis. On the other hand, loss of PTPN2 induced enhanced epithelial cell proliferation and promoted wound closure.
Antigen receptor-mediated depletion of FOXP3 (zeige FOXP3 Proteine) in induced regulatory T-lymphocytes via PTPN2 and FOXO1 (zeige FOXO1 Proteine)
A novel role for TCPTP in insulin (zeige INS Proteine) secretion and uncover STAT3 (zeige STAT3 Proteine) as a physiologically relevant target for TCPTP in the endocrine pancreas.
dysfunction of PTPN2 results in aberrant T-cell differentiation and intestinal dysbiosis similar to those observed in human CD. Our findings indicate a novel and crucial role for PTPN2 in chronic intestinal inflammation.
PTPN2 attenuates T-cell lymphopenia-induced proliferation.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported.
T-cell protein tyrosine phosphatase
, tyrosine-protein phosphatase non-receptor type 2
, T cell protein-tyrosine phosphatase
, protein-tyrosine phosphatase PTP-2
, protein-tyrosine phosphatase PTP-S
, phosphoprotein phosphatase
, protein tyrosine phosphatase 1B
, protein tyrosine phosphatase, non-receptor type 2, like