anti-PTK2B (PTK2B) Antikörper

Bezeichnung:: anti-PTK2B Protein tyrosine Kinase 2 beta Antikörper (PTK2B)

Auf www.antikoerper-online.de finden Sie aktuell 260 PTK2B Protein tyrosine Kinase 2 beta (PTK2B) Antikörper von 26 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PTK2B Kits (17) und PTK2B Proteine (14) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 310 PTK2B Produkte verfügbar.

Synonyme:: Akt, CADTK, CAKB, CAKbeta, E430023O05Rik, FADK2, fak1b, FAK2, PKB, PKB/Akt, PKBalpha, PTK, ptk2.2, ptk2b, Pyk2, Rac, Raftk, si:ch1073-355e8.1

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	PTK2B	11651	P31750
	PTK2B	2185	Q14289
	PTK2B	50646	P70600
Alle Spezies anzeigen Weitere Synonyme anzeigen

Meistgesuchte Reaktivitäten zu anti-PTK2B (PTK2B) Antikörper

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anti-Mouse (Murine) PTK2B Antikörper:

anti-Human PTK2B Antikörper:

anti-Rat (Rattus) PTK2B Antikörper:

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Verknüpfte Pathways mit anti-PTK2B Antikörper

VEGF Signaling

Weitere Produktkategorien zu PTK2B Antikörper

Am meisten referenzierte anti-PTK2B Antikörper

Human Monoclonal PTK2B Primary Antibody für ICS - ABIN1177156 : Anand, Cucchiarini, Terwilliger, Ganju: The tyrosine kinase Pyk2 mediates lipopolysaccharide-induced IL-8 expression in human endothelial cells. in Journal of immunology (Baltimore, Md. : 1950) 2008 (PubMed)
Show all 6 Pubmed References
Human Monoclonal PTK2B Primary Antibody für ICS - ABIN1177155 : Avraham, Park, Schinkmann, Avraham: RAFTK/Pyk2-mediated cellular signalling. in Cellular signalling 2000 (PubMed)
Show all 6 Pubmed References
Human Monoclonal PTK2B Primary Antibody für IHC, ELISA - ABIN1724705 : Dylla, Deyle, Theunissen, Padurean, Verfaillie: Integrin engagement-induced inhibition of human myelopoiesis is mediated by proline-rich tyrosine kinase 2 gene products. in Experimental hematology 2004 (PubMed)
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Human PTK2B Primary Antibody für IHC - ABIN966926 : Gluck: Acid sensing in renal epithelial cells. in The Journal of clinical investigation 2004 (PubMed)
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Cow (Bovine) Polyclonal PTK2B Primary Antibody für WB - ABIN2779800 : Ling, Sheng, Braun: The calcium-dependent activity of large-conductance, calcium-activated K+ channels is enhanced by Pyk2- and Hck-induced tyrosine phosphorylation. in American journal of physiology. Cell physiology 2004 (PubMed)
Human Polyclonal PTK2B Primary Antibody für IF (p), IHC (p) - ABIN745118 : Cao, Zheng, Wang, Wang, Li, Li, Lai, Wang, Qin: Src blockage by siRNA inhibits VEGF-induced vascular hyperpemeability and osteoclast activity - an in vitro mechanism study for preventing destructive repair of osteonecrosis. in Bone 2015 (PubMed)
Human Polyclonal PTK2B Primary Antibody für ICC, IF - ABIN4348749 : Lu, Chen, Shimoda, Park, Zhang, Tran, Zhang, Semenza: Chemotherapy-Induced Ca(2+) Release Stimulates Breast Cancer Stem Cell Enrichment. in Cell reports 2017 (PubMed)
Human Polyclonal PTK2B Primary Antibody für IF, IHC - ABIN362252 : Tomomura, Hasegawa, Suda, Sakagami, Tomomura et al.: Serum calcium-decreasing factor, caldecrin, inhibits receptor activator of NF-?B ligand (RANKL)-mediated Ca2+ signaling and actin ring formation in mature osteoclasts via suppression of Src signaling ... in The Journal of biological chemistry 2012 (PubMed)
Show all 6 Pubmed References
Human Polyclonal PTK2B Primary Antibody für IF, IHC - ABIN362858 : Benzing, Gerke, Höpker, Hildebrandt, Kim, Walz: Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2. in Proceedings of the National Academy of Sciences of the United States of America 2001 (PubMed)
Show all 6 Pubmed References

Weitere Antikörper gegen PTK2B Interaktionspartner

Mouse (Murine) PTK2B Protein tyrosine Kinase 2 beta (PTK2B) Interaktionspartner

findings suggested E. faecalis LTA (zeige LTA Antikörper) may increased macrophages autophagy via inhibiting PI3K/Akt (zeige AKT1 Antikörper)/mTOR (zeige FRAP1 Antikörper) pathway and this process was Beclin1 (zeige BECN1 Antikörper) dependent.
LncARSR promotes hepatic lipogenesis via Akt (zeige AKT1 Antikörper)/SREBP-1c (zeige SREBF1 Antikörper) pathway and contributes to the pathogenesis of nonalcoholic steatohepatitis.
TLR2 confers a pivotal role in allergic airway inflammation via regulating the PI3K/Akt (zeige AKT1 Antikörper) signaling pathway-related autophagy in mice.
Finally, EGCG remarkably inhibited compound 48/80-induced phosphorylation of extracellular signal-regulated kinase (ERK (zeige EPHB2 Antikörper)) and imiquimod-induced p-AKT (zeige AKT1 Antikörper) in the spinal cord of mice, respectively. Collectively, these results indicated EGCG could be a promising strategy for anti-itch therapy.
both AKT phosphorylation and RAC-dependent membrane ruffling were markedly reduced by depletion of either APPL1 or MYO6. These results place MYO6 and its binding partners at a central nexus in cellular signaling linking actin dynamics at the cell surface and endosomal signaling in the cell cortex.
TXNIP (zeige TXNIP Antikörper) is a direct substrate of protein kinase B (AKT (zeige AKT1 Antikörper)) and is responsible for mediating AKT (zeige AKT1 Antikörper)-dependent acute glucose influx after growth factor stimulation.
Influence of 1mM MbetaCD on the fenoterol-driven changes in both contractility and NO level was strongly attenuated by inhibition of Gi-protein (pertussis toxin), Akt (Akt 1 (zeige AKT1 Antikörper)/2 kinase inhibitor) or NO-synthase (zeige NOS Antikörper) (L-NAME)..Obtained results suggest that slight cholesterol depletion upregulates Gi-protein/Akt (zeige AKT1 Antikörper)/NO-synthase (zeige NOS Antikörper) signaling that attenuates the positive inotropic response to b2-adrenergic stimulation
Akt1 (zeige AKT1 Antikörper) conditions the normal circadian rhythm in the vasculature more so than in other peripheral tissues where other AKT (zeige AKT1 Antikörper) isoforms or kinases might be important for daily rhythms.
UVB-irradiated or aged mice skin revealed that mTORC2 (zeige CRTC2 Antikörper) activity was significantly upregulated which in turn increased Akt (zeige AKT1 Antikörper) activation and Akt (zeige AKT1 Antikörper)-dependent IkappaB kinase alpha (zeige CHUK Antikörper) (IKKalpha (zeige CHUK Antikörper)) phosphorylation, and The increased mTORC2 (zeige CRTC2 Antikörper) signaling pathway during skin aging were associated to NF-kappaB (zeige NFKB1 Antikörper) activation.
this study reveals the function of IL-15 (zeige IL15 Antikörper) in astrocyte survival via Akt (zeige AKT1 Antikörper) phosphorylation in response to OGD (zeige FGFR1 Antikörper)-induced damage.

Human PTK2B Protein tyrosine Kinase 2 beta (PTK2B) Interaktionspartner

Interestingly, rs2279590 locus has a widespread enhancer effect on two nearby genes, protein tyrosine kinase 2 beta (PTK2B) and epoxide hydrolase-2 (EPHX2 (zeige EPHX2 Antikörper)); both of which have been previously associated with AD as risk factors.
thrombin (zeige F2 Antikörper) binding to PAR-1 (zeige MARK2 Antikörper) receptor activated Gi-protein/c (zeige PROC Antikörper)-Src (zeige SRC Antikörper)/Pyk2/EGFR (zeige EGFR Antikörper)/PI3K (zeige PIK3CA Antikörper)/Akt (zeige AKT1 Antikörper)/p42/p44 (zeige PSMC6 Antikörper) MAPK (zeige MAPK3 Antikörper) cascade, which in turn elicited AP-1 (zeige FOSB Antikörper) activation and ultimately evoked MMP-9 (zeige MMP9 Antikörper) expression and cell migration in SK-N-SH cells.
Multiple myeloma that is driven by deregulated iron homeostasis and/or Pyk2/beta-cateninn signaling is susceptible to deferasirox-induced apoptosis.
In summary, our data suggested that PYK2 via S6K1 (zeige RPS6KB1 Antikörper) activation modulated AR function and growth properties in prostate cancer cells. Thus, PYK2 and S6K1 (zeige RPS6KB1 Antikörper) may potentially serve as therapeutic targets for PCa (zeige FLVCR1 Antikörper) treatment.
Our findings suggest that Pyk2 plays an important role in the coordination of stabilization of beta-catenin (zeige CTNNB1 Antikörper) in the crosstalk between Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) and Wnt (zeige WNT2 Antikörper)/Ca(2 (zeige CA2 Antikörper)+) signaling pathways upon Wnt3a (zeige WNT3A Antikörper) stimulation in differentiating hNPCs.
STIM1 (zeige STIM1 Antikörper)-induced Ca(2 (zeige CA2 Antikörper)+) signaling activates Pyk2 to inhibit the interaction of VE-PTP (zeige PTPRB Antikörper) and VE-cadherin (zeige CDH5 Antikörper) and hence increase endothelial permeability.
Ascites and CCL18 (zeige CCL18 Antikörper) stimulate the phosphorylation and expression of Pyk2, which positively regulates ascites-induced ovarian cancer cell migration.
We demonstrated trophoblast cytoprotection by intervention with supraphysiological concentrations of relaxin (zeige 0 Antikörper), a process in part mediated through the PI3-kinase (zeige PIK3CA Antikörper)-Akt/PKB (zeige AKT1 Antikörper) cell survival pathway. These results provide further rationale for clinical investigation of relaxin (zeige 0 Antikörper) as a potential therapeutic in preeclampsia.
PTK2B polymorphism (rs28834970) could modify the risk of late-onset Alzheimer's disease (LOAD), and PTK2B polymorphism (rs28834970) and APOE may interact to increase LOAD risk in a Han Chinese population.
Studies suggest that PYK2 is a common downstream effector of ErbB (zeige EGFR Antikörper) and IL8 (zeige IL8 Antikörper) receptors, and that PYK2 integrates their signaling pathways through a positive feedback loop to potentiate breast cancer invasion.

Cow (Bovine) PTK2B Protein tyrosine Kinase 2 beta (PTK2B) Interaktionspartner

Ptk2b activation may play a key role in the signaling responses in ECs under hemodynamic influence [proline-rich tyrosine kinase 2]

PTK2B Antigen-Profil

Beschreibung des Gens

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.

Alternative names and synonyms associated with PTK2B

thymoma viral proto-oncogene 1 (Akt1) Antikörper
protein tyrosine kinase 2 beta (PTK2B) Antikörper
PTK2 protein tyrosine kinase 2 beta (Ptk2b) Antikörper
protein tyrosine kinase 2 beta (Ptk2b) Antikörper
protein tyrosine kinase 2aa (ptk2aa) Antikörper

Akt Antikörper
CADTK Antikörper
CAKB Antikörper
CAKbeta Antikörper
E430023O05Rik Antikörper
FADK2 Antikörper
fak1b Antikörper
FAK2 Antikörper
PKB Antikörper
PKB/Akt Antikörper
PKBalpha Antikörper
PTK Antikörper
ptk2.2 Antikörper
ptk2b Antikörper
Pyk2 Antikörper
Rac Antikörper
Raftk Antikörper
si:ch1073-355e8.1 Antikörper

Bezeichner auf Proteinebene für PTK2B

, , , , , , , , , , , , , , , , , , , , , , , , , , , AKT1 kinase PKB alpha RAC-PK-alpha RAC-alpha serine/threonine-protein kinase protein kinase B alpha protein kinase B-alpha proto-oncogene c-AKT related to A and C kinases CAK-beta FADK 2 PTK2B protein tyrosine kinase 2 beta calcium-dependent tyrosine kinase calcium-regulated non-receptor proline-rich tyrosine kinase cell adhesion kinase beta focal adhesion kinase 2 proline-rich tyrosine kinase 2 protein kinase B protein-tyrosine kinase 2-beta related adhesion focal tyrosine kinase cellular adhesion kinase beta protein tyrosine kinase 2 beta CADTK CAK beta PTK2 protein tyrosine kinase 2 beta fakb protein tyrosine kinase 2.2 protein tyrosine kinase 2aa protein tyrosine kinase 2b

GENE ID	SPEZIES
11651	Mus musculus
2185	Homo sapiens
421998	Gallus gallus
486102	Canis lupus familiaris
100342358	Oryctolagus cuniculus
19229	Mus musculus
50646	Rattus norvegicus
541008	Bos taurus
100157507	Sus scrofa
100734027	Cavia porcellus
386705	Danio rerio

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