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Several CDH13 polymorphisms associated with increased risk of diabetic retinopathy in Taiwanese patients with T2D
CDH13 single nucleotide polymorphism amplifies the negative associations of PM10 air pollution exposure and elevated blood pressure or hypertension in Korean men.
In this young Chinese population, CDH13 rs4783244 represents a key locus for cardiac structure, and confers stronger cardio-protection in longer sleep duration when contrasted with short sleep duration
Polymorphism in CDH13 is associated with nephropathy in subjects with type 1 diabetes.
The single nucleotide polymorphisms (SNPs) rs12596316AG genotype of the T-cadherin (CDH13) gene is associated with the susceptibility to metabolic syndrome (MS) among ethnic Han Chinese.
the data suggests that the CDH13 T > A (rs11646213) polymorphism is associated with decreased risk of developing hypertension in the Mexican population
nine ADHD candidate single nucleotide polymorphisms (SNPs) in seven genes were tested for association with PD in 5333 cases and 12,019 healthy controls. No significant association was observed.
CDH13 genetic polymorphisms are associated with adiponectin levels and ischemic stroke.
Study evaluated the associations between 6 SNPs in CDH13 and type 2 diabetes mellitus (T2DM) in a Han Chinese population. Results showed that the rs12596316 AG genotype was a risk genotype for the development of T2DM in the overdominant inheritance model; rs11646213, rs3865188, rs12444338, rs12051272, and rs7195409 had no observed associations with T2DM in terms of alleles, genotypes, and the various inheritance models.
The methylation status of CDH13 promoter was strongly associated with breast cancer risk. However, CDH13 promoter methylation was not significantly related to the OS and DFS of breast cancer and may have limited prognostic value for breast cancer patients
Studied the associations between genetic variants of CDH13 and type 2 diabetes (T2D), and its related parameters, in a Caucasian population.
Compared with adjacent normal tissues, the methylation frequencies of WIF-1, RASSF1A, and CDH13 genes were significantly higher but the mRNA levels of these 3 genes were significantly lower in EC tissues. The survival rates of patients with WIF-1, RASSF1A, and CDH13 methylations were significantly lower than those of patients without methylation
higher promoter methylation in colorectal cancer than in premalignant, normal, adjacent tissues; highest promoter methylation in poorly differentiated colorectal cancer
CDH13 genetic variants determine Chinese individuals' susceptibility to chronic obstructive pulmonary disease (COPD) and thus are efficient genetic biomarkers for early detection of COPD.
Strong Functional Association of adipor2 and cdh13 with adipoq
CDH13 Polymorphisms are Associated with Adiponectin Levels and Metabolic Syndrome Traits Independently of Visceral Fat Mass.
CDH13 locus variants and adiponectin levels are associated with circulating levels of cellular adhesion molecules and adiposity status in a differential manner that interacts with sex
This study finding significant excess of rare nonsynonymous variants exclusive to European Americans smokers in CHD13.
Data demonstrate for the first time that SHP1 methylation has high specificity for diagnosis of endometrial carcinoma, while CDH13 promoter methylation plays a role in the earlier stage.
The present study identified a new genetic factor for CRC risk and an interaction between CDH13 and APN in CRC risk. These genetic factors may be useful for predicting CRC risk.
Studied role of cadherin 13 (CDH13) levels in adipose tissue and obesity; found CDH13 levels are affected by obesity in mouse models and humans and are restored by weight loss in humans.
Neonatal maternal separation (MS) lead to increased anxiety-like behavior in Cdh13(-/-) mice compared to the other two MS groups. Cdh13(-/-) mice showed a context-dependent effect on stress- & anxiety-related behavior, impaired extinction learning following contextual fear conditioning & decreased impulsivity, & a mild decrease in errors in the Barnes maze & reduced risk-taking in the light-dark transition test after MS.
Findings show that Cdh13 is critical for inhibitory function of Golgi cells, and that GlyT2::Cre-mediated deletion of Cdh13 in non-executive centers of the brain, such as the cerebellum, may contribute to cognitive and social behavioral deficits linked to neurological disorders.
Studies findings identified a novel protective role for cadherin-13 in cortical neuron development.
using rat and murine aortic smooth muscle cells as experimental models, we surveyed the ability of T-cadherin to regulate autophagy in SMCs during serum-starvation stress. Overall our findings have identified T-cadherin as a novel positive regulator of autophagy and survival in smooth muscle cells
T-cadherin was essential for accumulation of adiponectin in the neointima and atherosclerotic plaque lesions, and the adiponectin-T-cadherin association protected against vascular injury.
T-cadherin deficiency causes endothelial dysfunction in Type II Diabetes Mellitus.
a unique key feature of the T-cad prodomain is its involvement in binding of the T-cad repeats 1 and 2 to adiponectin; adiponectin positively regulates T-cad abundance
CDH13 is a negative regulator of inhibitory synapses in the hippocampus, and provide insights into how CDH13 dysfunction may contribute to the excitatory/inhibitory imbalance observed in Attention Deficit Disorder with Hyperactivity.
These data show that both circulating and tissue-bound Adipo levels are dependent on Tcad and, in reverse, regulate tissue Tcad levels through a positive feedback loop.
These data highlight a previously unrecognized role for T-cadherin in limb revascularization and show that it is essential for mediating the vascular actions of adiponectin.
T-cad does not mediate the protective effects of adiponectin in allergic airways responses in mice
T-cadherin is a component of insulin granules, suggesting that it contributes to the regulation of insulin secretion independently of direct interactions with adiponectin.
T-cad can exert pleiotropic effects on squamous cell carcinoma progression; up- or down-regulation of T-cad can promote tumour expansion in vivo.
T-cadherin protects from stress-induced pathological cardiac remodeling by binding APN and activating its cardioprotective functions.
hyperexpression of T-cadherin in the B16F10 cells suppresses the proliferation of these cells in vitro and the growth of the tumor masses formed by melanoma cells on the chorioallantoic membrane and their neovascularization
Expression of T-cadherin in Basal keratinocytes of skin.
T-cadherin has a role in growth regulation involving p21(CIP1/WAF1) expression and G2 arrest
Because T-cadherin is a glycosylphosphatidylinositol-anchored extracellular protein, it may act as a coreceptor for an as-yet-unidentified signaling receptor through which adiponectin transmits metabolic signals.
T-cadherin is novel modulator of angiogenesis. Molecule can be exploited as target for modulation of therapeutic angiogenesis, as well as for prevention of pathological conditions associated with abnormal neovascularization.
This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
, H-cadherin (heart)
, cadherin 13, H-cadherin (heart)
, heart cadherin