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Human Polyclonal ARF4 Primary Antibody für ELISA, WB - ABIN4281358
Jang, Jang, Ko: Regulation of ADP-ribosylation factor 4 expression by small leucine zipper protein and involvement in breast cancer cell migration. in Cancer letters 2011
The newly identified ciliary targeting VxPx motif present in rhodopsin (zeige RHO Antikörper) binds the small GTPase (zeige RACGAP1 Antikörper) Arf4 and regulates its association with the trans-Golgi network.
Data suggest that, when compared to intestinal epithelial cells (IECs) from germ-free mice, IECs from mice with commensal bacteria exhibit increased expression of microRNA-21-5p; up-regulation of expression of microRNA-21-5p appears to increase IEC permeability and up-regulates ADP ribosylation factor 4 (Arf4/ARF4) in mouse and human cells.
ARF4 is required for Presenilin basal body localization, Notch (zeige NOTCH1 Antikörper) signaling, and subsequent epidermal differentiation.
These findings are consistent with Arf4 playing a critical role in endomembrane trafficking, particularly in the pancreas, but not in ciliary function.
This work suggests that while Arf4 is not required for ciliary assembly, it is important for the efficient transport of fibrocystin (zeige PKHD1 Antikörper) to cilia, and also plays critical roles in non-ciliary processes
Findings suggest that Arf4 is a critical modulator of DG-mediated pattern separation by regulating dendritic spine development.
ASAP1 (zeige ASAP1 Antikörper) is a scaffold bringing together the proteins needed for transport to the cilia including the GTP-binding protein (zeige DRG1 Antikörper) Arf4 & the 2 G proteins of the Rab (zeige HRB Antikörper) family--Rab11 (zeige RAB11A Antikörper) & Rab8 (zeige RAB8A Antikörper)--linked by the Rab8 (zeige RAB8A Antikörper) guanine nucleotide exchange factor (zeige ARHGEF12 Antikörper) Rabin8 (zeige RAB3IP Antikörper).
somal CAPS2 (zeige CADPS2 Antikörper) is associated with the Golgi membrane, and mediates binding and recruitment of the GDP-bound form of ARF4 and ARF5 (zeige ARF5 Antikörper) to the Golgi membrane
a functional role for CAPS1 (zeige CAPS Antikörper) in regulating DCV trafficking in the trans-Golgi network; this activity occurs via protein-protein interaction with ARF4/ARF5 (zeige ARF5 Antikörper) in a GDP-dependent manner.
ARF1 (zeige ARF1 Antikörper)+ARF4 are required for integrity of recycling endosomes but are involved in distinct transport pathways: the pair regulates retrograde transport from endosomes to the TGN (zeige TG Antikörper).
A CREB3 (zeige CREB3 Antikörper)-ARF4 signalling cascade may be part of a Golgi stress response set in motion by stimuli compromising Golgi capacity.
a crucial role for class II Arf (zeige CDKN2A Antikörper) proteins (Arf4 and Arf5 (zeige ARF5 Antikörper)) in the dengue flavivirus life cycle
The lipid droplets deposition and the cellular triacylglycerol content are significantly increased by siRNA-mediated depletion of Arf4.
sLZIP-regulated ARF4 expression in response to phorbol 12-myristate 13-acetate is involved in breast cancer cell migration.
Arf4 regulates PLA2G6 (zeige PLA2G6 Antikörper)-A activity together with Arf1 (zeige ARF1 Antikörper); and gene silencing of Arf4 was shown to alter cytosolic coat protein (zeige GOLPH3 Antikörper) I (zeige ANXA2 Antikörper) subunit recruitment to the early secretory pathway.
ARF4 is a critical molecule that directly regulates cellular phospholipase D2 (zeige PLD2 Antikörper) activity and this ARF4-mediated PLD2 (zeige PLD2 Antikörper) activation stimulates AP-1 (zeige FOSB Antikörper)-dependent transcription in the EGF (zeige EGF Antikörper)-induced cellular response
ARF4L (zeige ARL4D Antikörper) occurred on the plasma membrane after binding to GTP (zeige AK3 Antikörper) and into endosomes while binding to GDP; the inactive form of ARF4L (zeige ARL4D Antikörper) causes localization of transferrin (zeige Tf Antikörper) receptors to the endosomes while the active form causes transport to the plasma membrane.
ARF4 participates in the regulation of glioblastoma apoptosis through the inhibition of stress-mediated apoptotic signals
swine ARF4 gene is over expressed in muscle, fat, heart, spleen, liver, and ovary and moderately expressed in lung and kidney but weakly expressed in small intestine
This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. The ARF proteins are categorized as class I, class II and class III\; this gene is a class II member. The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. This gene is the most divergent member of the human ARFs. Conflicting map positions at 3p14 or 3p21 have been reported for this gene.
ADP-ribosylation factor 4
, ADP-ribosylation factor 2
, ADP-ribosylation factor family-like protein