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Five out of twelve patients with defects in either of MSH2 (zeige MSH2 Proteine), RAD50 and NBN (zeige NBN Proteine) genes suffered from rare life-threatening AE, more frequently than in control group (p = 0.0005). When all detected variants were taken into account, the majority of patients (8 out of 15) suffered from life-threatening toxicity during chemotherapy.
Low RAD50 expression is associated with low-grade epithelial ovarian cancer.
although recruitment of the MRE11 (zeige MRE11A Proteine)-RAD50-NBS1 (zeige NBN Proteine) (MRN) DSB-sensing complex to viral genomes and activation of the ATM (zeige ATM Proteine) kinase can promote KSHV replication, proteins involved in nonhomologous end joining (NHEJ) repair restrict amplification of viral DNA.
Mre11 (zeige MRE11A Proteine)-Rad50-Nbs1 (zeige NBN Proteine) complex initiates DNA double strand break repair.
symmetrical engagement of the Rad50 catalytic head domains with ATP bound at both sites is important for MRN functions in eukaryotic cells.
The results illuminate the important role of Nbs1 (zeige NBN Proteine) and CtIP (zeige RBBP8 Proteine) in determining the substrates and consequences of human Mre11 (zeige MRE11A Proteine)/Rad50 nuclease (zeige DCLRE1C Proteine) activities on protein-DNA lesions.
identification of a novel association for longevity in the RAD50/IL13 (zeige IL13 Proteine) region on chromosome 5q31.1; the lead SNP rs2706372 is located in the intronic region of the RAD50 gene and is in strong linkage disequilibrium with other associated SNPs close to IL13 (zeige IL13 Proteine) and IL5 (zeige IL5 Proteine)
the structure of the human Rad50 hook and coiled-coil domains, was determined.
although Mre11 (zeige MRE11A Proteine) is required for efficient HR-dependent repair of ionizing-radiation-induced DSBs, Mre11 (zeige MRE11A Proteine) is largely dispensable for DSB resection in both chicken DT40 and human TK6 B cell lines.
The high expression of MRE11 (zeige MRE11A Proteine)-RAD50-NBS1 (zeige NBN Proteine) complex constituents could be a predictor for poor prognosis and chemoresistance in gastric cancer
RHS6 is a critical regulatory element for allergic airway inflammation and for coordinate regulation of Th2 cytokine genes by recruiting GATA3 (zeige GATA3 Proteine), SATB1 (zeige SATB1 Proteine), and IRF4 (zeige IRF4 Proteine).
Low RAD50 expression is associated with B-cell lymphomas.
The authors demonstrate that ATM (zeige ATM Proteine) can be activated by DNA double-strand breaks in the absence of the Mre11 (zeige MRE11A Proteine)-Rad50-NBS1 (zeige NBN Proteine) (MRN) sensor complex.
Rad50 hook domain strongly influences Mre11 (zeige MRE11A Proteine) complex-dependent DDR (zeige DDR1 Proteine) signaling, tissue homeostasis, and tumorigenesis.
RAD50, DNA-PKcs (zeige PRKDC Proteine) kinase activity, and transcription context are each important to limit incorrect end use during EJ repair of multiple DSBs, but each has distinct roles during repair events requiring end processing
Data show that CS-mediated SCC (zeige CYP11A1 Proteine) lethality was mitigated in irradiated gain-of-function Rad50(s/s) mice, and epistasis studies order Rad50 upstream of Mre11 (zeige MRE11A Proteine).
MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX.
Rad50 mutant mice (Rad50(S/S) mice) exhibited growth defects and cancer predisposition.
the RAD50 LCR (zeige CBR2 Proteine) has a complex and dual role in Th1 (zeige HAND1 Proteine) and Th2 differentiation, communicating early T cell antigen receptor and cytokine signals to the IL-4 (zeige IL4 Proteine)/IL-13 (zeige IL13 Proteine) locus in both differentiating cell types
enhancer region with four DNase I (zeige DNASE1 Proteine) hypersensitive clusters, three of which are highly conserved and predominantly expressed in Th2 cells
Study identified a stringent requirement for Mre11 (zeige MRE11A Proteine)-Rad50-Nbs (zeige NLRP2 Proteine) (MRN) function in telomere protection during early embryonic development.
MRN (Mre11 (zeige MRE11A Proteine), Rad50, and Nbs1 (zeige NLRP2 Proteine)) complex, CtIP (zeige RBBP8 Proteine), and BRCA1 are required for both the removal of Top2 (zeige TOP2 Proteine)-DNA adducts and the subsequent resection of Top2 (zeige TOP2 Proteine)-adducted DSB ends.
MRN (MRE11 (zeige MRE11A Proteine)-RAD50-NBS1 (zeige NLRP2 Proteine)) complex has role in ATR activation via TOPBP1 (zeige TOPBP1 Proteine) recruitment.
Results indicate a role for the X. laevis Mre11 (zeige MRE11A Proteine)/Rad50/Nbs1 (zeige NLRP2 Proteine) complex in microhomology-mediated end joining.
These findings suggest that the MRN complex is a crucial mediator in the process whereby ATM (zeige ATM Proteine) promotes the TopBP1 (zeige TOPBP1 Proteine)-dependent activation of ATR-ATRIP (zeige ATRIP Proteine) in response to double-stranded DNA breaks.
suggests that Mre11 (zeige MRE11A Proteine)-Rad50-Nbs1 (zeige NLRP2 Proteine) inactivation participates in the down-regulation of damage signaling during checkpoint recovery following double-strand breaks repair.
Data show that the product of the PHS1 (zeige PTGS1 Proteine) gene is a cytoplasmic protein (zeige BLZF1 Proteine) that functions by controlling transport of RAD50 from cytoplasm to the nucleus.
The protective role of Rad50 protein on shortened telomeres results from its action in constraining recombination to sister chromatids and thus avoiding end-to-end interactions.
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.
DNA repair protein RAD50
, RAD50 homolog (S. cerevisiae)
, RAD50 homolog
, Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining
, Rad50 DNA repair/recombination protein
, DNA repair protein RAD50-like