SSH1 Proteine (SSH1)

Mouse (Murine) Slingshot Homolog 1 (Drosophila) (SSH1) Interaktionspartner

1. Caspase-11 targets cofilin via the RhoA GTPase, whereas caspase-1 engages the Slingshot phosphatase

2. SSH1L knockdown, like S1P treatment, increased cardiomyocyte survival and preserved mitochondrial integrity after oxidative stress

3. EphA signaling promotes actin-based dendritic spine remodeling through slingshot 1.

4. PDGF activates SSH1L in VSMC by a mechanism that involves Nox1-mediated oxidation of 14-3-3 and Ser-834 SSH1L auto-dephosphorylation.

5. Knockdown of SSH1 expression by RNA interference significantly suppressed stress fiber formation in C2C12 myoblast cells, indicating a role for SSH1 in stress fiber formation or stabilization in cells.

Human Slingshot Homolog 1 (Drosophila) (SSH1) Interaktionspartner

1. SSH1 binds to gelsolin via actin filaments in the cytosolic fraction. Gelsolin promoted solubilization of actin filaments and SSH1 in cell-free assays and in cultured cells.

2. the N-terminal PH-like domain plays a critical role in F-actin binding and F-actin-mediated activation of the cofilin-phosphatase activity of SSH1

3. Results reveal that SSH1L is upregulated in a subset of PCs and that the SSH1L/cofilin-1 signal pathway is associated positively in PC with cell migration.

4. Authors show that viral penetration-induced calcium release facilitated herpes simplex virus type 1 intracellular trafficking through activating slingshot 1 (SSH), a phosphatase regulating actin filament dynamics.

5. The association of IRS4 with SSH1 contributes to localized activation of cofilin in membrane protrusions.

6. Slingshot 1 downregulation in neuronal cells inactivates cofilin to facilitate HSV-1 replication.

7. Results identify a novel frameshift mutation in this gene implicated in disseminated superficial actinic porokeratosis in 4 Chinese families

8. Thus this study provides evidence for a novel role of LIMK1 and SSH-1L in selectively regulating endothelial cell inflammation associated with intravascular coagulation.

9. Our work provides evidence that supports the positive role of SSH1L in the mechanism of stem cell differentiation into cardiomyocyte-like cells.

10. A high expression of SSH-1L in peripheral eosinophils in acute exacerbations of asthma may play a role in the activation and migration of eosinophils.

11. EphA signaling promotes actin-based dendritic spine remodeling through slingshot 1.

12. identified Ser 402 as a new phosphorylation site within the catalytic domain of human slingshot 1 (SSH1).

13. Results show the significance of SSH1L in estrogen-induced osteoblastogenic differentiation in favor of adipogenic differentiation from hMSCs.

14. SSH1 plays a critical role in cytokinesis by dephosphorylating and reactivating cofilin in later stages of mitosis

15. findings suggest that SSH1L is activated downstream of PI3K and plays a critical role in insulin-induced membrane protrusion by dephosphorylating and activating cofilin

16. SSH1L is locally activated by translocation to and association with F-actin in lamellipodia in response to neuregulin-1beta and 14-3-3 proteins negatively regulate SSH1L activity by sequestering it in the cytoplasm.

17. SSH1 mutations seen in patients with disseminated superficial actinic porokeratosis

18. a multi-protein complex consisting of SSH-1L, LIMK1, actin, and the scaffolding protein, 14-3-3zeta, is involved, along with the kinase, PAK4, in the regulation of ADF/cofilin activity

19. Ca2+-induced cofilin dephosphorylation is mediated by calcineurin-dependent activation of SSH1L

20. identified sites that play unique roles in the control of subcellular localization and F-actin-mediated activation of SSH1L