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Caspase-11 (zeige CASP4 Proteine) targets cofilin (zeige CFL1 Proteine) via the RhoA GTPase, whereas caspase-1 (zeige CASP1 Proteine) engages the Slingshot phosphatase
SSH1L knockdown, like S1P (zeige S1PR1 Proteine) treatment, increased cardiomyocyte survival and preserved mitochondrial integrity after oxidative stress
EphA signaling promotes actin-based dendritic spine remodeling through slingshot 1.
PDGF (zeige PDGFA Proteine) activates SSH1L in VSMC by a mechanism that involves Nox1 (zeige NOX1 Proteine)-mediated oxidation of 14-3-3 (zeige YWHAQ Proteine) and Ser (zeige SIGLEC1 Proteine)-834 SSH1L auto-dephosphorylation.
Knockdown of SSH1 expression by RNA interference significantly suppressed stress fiber formation in C2C12 myoblast cells, indicating a role for SSH1 in stress fiber formation or stabilization in cells.
SSH1 binds to gelsolin (zeige GSN Proteine) via actin filaments in the cytosolic fraction. Gelsolin (zeige GSN Proteine) promoted solubilization of actin filaments and SSH1 in cell-free assays and in cultured cells.
the N-terminal PH-like domain plays a critical role in F-actin binding and F-actin-mediated activation of the cofilin (zeige CFL1 Proteine)-phosphatase activity of SSH1
Results reveal that SSH1L is upregulated in a subset of PCs and that the SSH1L/cofilin-1 (zeige CFL1 Proteine) signal pathway is associated positively in PC with cell migration.
Authors show that viral penetration-induced calcium release facilitated herpes simplex virus type 1 intracellular trafficking through activating slingshot 1 (SSH), a phosphatase regulating actin filament dynamics.
The association of IRS4 (zeige IRS4 Proteine) with SSH1 contributes to localized activation of cofilin (zeige CFL1 Proteine) in membrane protrusions.
Slingshot 1 downregulation in neuronal cells inactivates cofilin (zeige CFL1 Proteine) to facilitate HSV-1 replication.
Thus this study provides evidence for a novel role of LIMK1 (zeige LIMK1 Proteine) and SSH-1L in selectively regulating endothelial cell inflammation associated with intravascular coagulation.
Our work provides evidence that supports the positive role of SSH1L in the mechanism of stem cell differentiation into cardiomyocyte-like cells.
A high expression of SSH-1L in peripheral eosinophils in acute exacerbations of asthma may play a role in the activation and migration of eosinophils.
The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
, SSH-like protein 1
, protein phosphatase Slingshot homolog 1
, slingshot 1L
, slingshot-like 1
, slingshot homolog 1