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Human PDE4D Protein expressed in Wheat germ - ABIN1314468
Branham, Mayorga, Tomes: Calcium-induced acrosomal exocytosis requires cAMP acting through a protein kinase A-independent, Epac-mediated pathway. in The Journal of biological chemistry 2006
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These results indicate that Phosphodiesterase-4D overexpression may be involved in the development of surgery-induced cognitive dysfunction in mice.
The effect of dobutamine as a positive inotrope is impaired in mice with cecal ligation and puncture-induced sepsis without changes in cardiac beta1-adrenoceptor signaling as a result of cAMP breakdown achieved by upregulated phosphodiesterase 4D
In vivo knockdown of (zeige FN1 Proteine) PDE4D5 inhibited inflammation at athero-prone sites (zeige TWIST1 Proteine)
Results indicate that the cyclic AMP (zeige TMPRSS5 Proteine) (cAMP) increase is caused by the attenuation of phosphodiesterase (PDE (zeige TWIST1 Proteine)) activity adrenal cortex-derived Y-1 cell line.
The authors demonstrate that the Attention Deficit Disorder with Hyperactivity phenotype depends on a dysregulation of CREB (zeige CREB1 Proteine) signaling exerted by a kinase-independent PI3Kgamma (zeige PIK3CG Proteine)-PDE4D interaction in the noradrenergic neurons of the locus coeruleus.
SIK1 serves as a part of a self-regulatory circuit to modulate insulin (zeige INS Proteine) secretion from pancreatic beta-cells by controlling cAMP concentration through modulation of PDE4D activity.
Cytokine-induced iNOS and ERK1/2 inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle, contributing to colonic dysmotility during inflammation.
the loss of function of either DISC1 (zeige DISC1 Proteine) or ATF4 (zeige ATF4 Proteine) increases PDE4D9 transcription, and the association of DISC1 (zeige DISC1 Proteine) with the PDE4D9 locus requires ATF4 (zeige ATF4 Proteine)
these results suggest that Pde4d might serve specific biological functions in regulating the development process of the mouse embryo, and that CpG methylation of the Pde4d promoter may play an important role in regulating Pde4d at a transcriptional level.
Calcineurin regulates degradation of phosphodiesterase 3B, in addition to phosphodiesterase 4D.
TT genotype of SNP87 in PDE4D was associated with an increased risk for 3-month unfavorable outcome after total ischemic stroke, as well as stroke due to large-artery atherosclerosis and small-artery occlusion, in a Chinese population.
SNP 83 of PDE4D gene may increase the risk for developing ischemic stroke whereas SNP 87 and SNP45 of PDE4D may not be associated with the risk of ischemic stroke in the North Indian population
Results provide new information concerning the mechanism whereby the mutations identified in the ACRDYS2 dysregulate PDE4D activity, and give insights into rare diseases involving the cAMP signaling pathway.
This supports PDE4D5 and RACK1 as potential regulators of cell adhesion, spreading and migration through the non-classical exchange protein activated by cyclic AMP (EPAC1)/Rap1 signalling route
PDE4D isoform composition is altered in localized prostate cancer and it can be used both as a diagnostic as well as a prognostic biomarker.
Genetic analysis identified the identical, novel heterozygous missense mutation of the PDE4D gene c.569C>T (p.Ser190Phe) in two patients in same family. This case illustrates the significant phenotypic variability of acrodysostosis even within one family with identical mutations.
Screening of PRKAR1A (zeige PRKAR1A Proteine) and PDE4D in a Large Italian Series of Patients Clinically Diagnosed With Albright Hereditary Osteodystrophy and/or Pseudohypoparathyroidism
p53 (zeige TP53 Proteine) induced the transcription of miR (zeige MLXIP Proteine)-139-5p, which in turn suppressed the protein levels of phosphodiesterase 4D (PDE4D), an oncogenic protein involved in multiple tumor promoting processes.
High PDE4D expression is associated with melanoma.
cells on fibronectin (zeige FN1 Proteine) suppressed cAMP via enhanced phosphodiesterase (PDE (zeige ALDH7A1 Proteine)) activity, through direct binding of integrin alpha5 to phosphodiesterase-4D5
demonstrate the presence of PDE4D transcript and protein, but also show an active enzyme, suggesting a functional role of PDE4D in bovine mammary gland
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.
phosphodiesterase E3 dunce homolog, Drosophila
, phosphodiesterase 4D, cAMP-specific
, cAMP-specific 3',5'-cyclic phosphodiesterase 4D-like
, phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)
, cAMP-specific 3',5'-cyclic phosphodiesterase 4D
, cAMP-specific phosphodiesterase 4D
, cyclic AMP specific phosphodiesterase PDE4D5A
, cAMP-specific phosphodiesterase PDE4D6
, Phosphodiesterase 4D cAMP-specific (dunce
, Phosphodiesterase 4D, cAMP-specific (dunce
, cAMP-specific phosphodiesterase PDE4D
, cAMP-specific phosphodiesterase splice variant PDE4D8
, phosphodiesterase 4D, cAMP specific
, hypothetical protein