PAF1 Proteine (PAF1)

Bezeichnung:: Paf1, RNA Polymerase II Associated Factor, Homolog (S. Cerevisiae) Proteine (PAF1)

Auf www.antikoerper-online.de finden Sie aktuell 3 Paf1, RNA Polymerase II Associated Factor, Homolog (S. Cerevisiae) (PAF1) Proteine von 2 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PAF1 Antikörper (65) und und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 73 PAF1 Produkte verfügbar.

Synonyme:: 5730511K23Rik, AA675045, f23149_1, im:6906070, paf1, paf1l, pd2, RGD1306219, wu:fb80a09

alle Proteine anzeigen	Gen	GeneID	UniProt
	PAF1	54623	Q8N7H5
	PAF1	54624	Q8K2T8
	PAF1	361531	Q4V886
Weitere Synonyme anzeigen

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Weitere Proteine zu PAF1 Interaktionspartnern

Human Paf1, RNA Polymerase II Associated Factor, Homolog (S. Cerevisiae) (PAF1) Interaktionspartner

a subset of enhancers can primarily modulate gene expression by controlling the release of paused Pol II in a PAF1 (zeige PEX2 Proteine)-dependent manner.
These results reveal ubiquitin-proteasome system regulation of Paf1 (zeige PEX2 Proteine) and suggest downregulation of ubiquitin-proteasome system in elevating Paf1 (zeige PEX2 Proteine)'s abundance in poorly differentiated cancers.
High PAF1 (zeige PEX2 Proteine) expression is associated with ovarian cancer.
Overexpression of PD2 leads to increased tumorigenicity and metastasis in pancreatic ductal adenocarcinoma.
Propose that degradation of MYC (zeige MYC Proteine) limits the accumulation of MYC (zeige MYC Proteine)/PAF1C complexes during transcriptional activation.
Mechanistic studies indicated that PAF1C could promote lung cancer cell proliferation through regulating c-MYC (zeige MYC Proteine) transcription.
CNOT4 (zeige CNOT4 Proteine) controls the degradation of chromatin-unbound PAF1 (zeige PEX2 Proteine) via the 26S proteasome (zeige Psmd4 Proteine).
this study found that Pol II-associated factor 1 (PAF1 (zeige PEX2 Proteine)) is a critical regulator of paused Pol II release, that positive transcription elongation factor b (P-TEFb (zeige CDK9 Proteine)) directly regulates the initial recruitment of PAF1 (zeige PEX2 Proteine) complex (PAF1C) to genes, and that the subsequent recruitment of CDK12 (zeige CRKRS Proteine) is dependent on PAF1C.
This study reveals an evolutionarily conserved role for PAF1 (zeige PEX2 Proteine) as a regulator of promoter-proximal pausing by RNA Pol II in all metazoans, including human.
PD2 is a novel cancer stem cell (CSC) maintenance protein, loss of which renders the CSCs more susceptible to drug-induced cell death.

Mouse (Murine) Paf1, RNA Polymerase II Associated Factor, Homolog (S. Cerevisiae) (PAF1) Interaktionspartner

link Paf1C with PolII elongation and RNA processing indicates that Paf1C subunits could play roles in controlling transcript length through suppression of PolII accumulation at transcription start site (TSS (zeige RPL38 Proteine))-proximal pA sites
The PAF1 (zeige PEX2 Proteine) complex is required for mammalian development, likely through regulation of H3K36me3, indicating a functional conservation of the PAF1 (zeige PEX2 Proteine) complex from yeast to mammals in vivo.
As part of a cell-intrinsic transcriptional pathway, Paf1 (zeige PEX2 Proteine) regulates neuronal migration in the brain.
MLL (zeige MLL Proteine) interacts directly with the polymerase associated factor complex (PAFc) via Paf1 (zeige PEX2 Proteine) and CTR9. PAFc augments MLL (zeige MLL Proteine) and MLL (zeige MLL Proteine)-AF9 (zeige MLLT3 Proteine) mediated transcriptional activation of Hoxa9 (zeige HOXA9 Proteine) and their interaction is essential for leukemogenesis.
show that Paf1/PD2 is overexpressed in mouse embryonic stem cells (ESCs (zeige NR2E3 Proteine)) and is involved in the maintenance of mouse ESCs (zeige NR2E3 Proteine).

Zebrafish Paf1, RNA Polymerase II Associated Factor, Homolog (S. Cerevisiae) (PAF1) Interaktionspartner

The PAF1 complex differentially regulates cardiomyocyte specification.

PAF1 Protein Überblick

Protein Überblick

This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with PAF1

PAF1 homolog, Paf1/RNA polymerase II complex component (PAF1)
Paf1, RNA polymerase II complex component (Paf1)
PAF1 homolog, Paf1/RNA polymerase II complex component (paf1)
PAF1 homolog, Paf1/RNA polymerase II complex component L homeolog (paf1.L)
RNA polymerase II-associated factor 1 homolog pseudogene (LOC100019208)
RNA polymerase II-associated factor 1 homolog (LOC100161171)
paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) (paf1)
RNA polymerase II-associated factor 1 homolog (LOC100639019)
RNA polymerase II-associated factor 1 homolog (LOC100650306)
PAF1 homolog, Paf1/RNA polymerase II complex component (Paf1)
Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) (PAF1)

5730511K23Rik Protein
AA675045 Protein
f23149_1 Protein
im:6906070 Protein
paf1 Protein
paf1l Protein
pd2 Protein
RGD1306219 Protein
wu:fb80a09 Protein

Bezeichner auf Proteinebene für PAF1

RNA polymerase II-associated factor 1 homolog , pancreatic differentiation protein 2 , PD2-like protein , paf1, RNA polymerase II associated factor, homolog, like , Paf1, RNA polymerase II associated factor, homolog

GENE ID	SPEZIES
54623	Homo sapiens
54624	Mus musculus
394974	Xenopus (Silurana) tropicalis
446278	Xenopus laevis
553020	Danio rerio
100019208	Monodelphis domestica
100161171	Acyrthosiphon pisum
100172552	Pongo abelii
100194999	Salmo salar
100411768	Callithrix jacchus
100465029	Ailuropoda melanoleuca
100514194	Sus scrofa
100543667	Meleagris gallopavo
100594485	Nomascus leucogenys
100639019	Amphimedon queenslandica
100650306	Bombus terrestris
361531	Rattus norvegicus
528744	Bos taurus
100713356	Cavia porcellus

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