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This study shown that CX3CR1 expression in both Microglia and Astrocytes in hippocampus in affected by stroke, Alzheimer's disease, and Lewy body dementia.
The US28 gene product has maintained the function of the ancestral gene and has the ability to bind and signal in response to human CX3CL1 (zeige CX3CL1 Proteine), the natural ligand for CX3CR1.
Our findings demonstrate that motility, invasion, and contact-independent growth of PDAC cells all increase following CX3CL1 (zeige CX3CL1 Proteine) exposure, and that antagonism of CX3CR1 by the inhibitor JMS (zeige ATRX Proteine)-17-2 reduces each of these phenotypes and correlates with a downregulation of AKT (zeige AKT1 Proteine) phosphorylation.
in Crohn's disease patients, a missense mutation in the gene encoding CX3CR1 was identified and found to be associated with impaired antifungal responses
CX3CL1 (zeige CX3CL1 Proteine)/CX3CR1 axis plays a key role in the development of ischemia-induced oligodendrocyte injury via p38MAPK (zeige MAPK14 Proteine) signaling pathway.
Soluble FKN that was efficiently shed from the surface of LPS (zeige IRF6 Proteine)-activated ECs in response to binding of CD16 (zeige CD16 Proteine)(+) monocytes to ECs, diminished monocyte adhesion in down-regulating CX3CR1 expression on the surface of CD16 (zeige CD16 Proteine)(+) monocytes resulting in decreased TNF (zeige TNF Proteine)-secretion.
CX3CR1 genetic variants were not associated with risk of atherosclerotic coronary heart disease and glucometabolic traits in European ancestry cohort. In a South Asian cohort, identified CX3CR1 SNP associated with myocardial infarction and type II diabetes mellitus.
FKN and CX3CR1 expression was significantly increased in pancreatic ductal adenocarcinoma (PDAC) tissues, especially in the metastatic samples, and was highly-correlated with severity of PDAC. Ectopic expression of FKN promoted the proliferation and migration of PDAC, while knockdown of CX3CR1 reversed the function of FKN.
CX3CL1 (zeige CX3CL1 Proteine) is upregulated in both human and murine tumors following VEGF (zeige VEGFA Proteine) signaling blockade, resulting in recruitment of CX3CR1+Ly6Clo monocytes into the tumor
The fractalkine (zeige CX3CL1 Proteine) functions on the activation of the AKT (zeige AKT1 Proteine)/NF-kappaB (zeige NFKB1 Proteine)/p65 (zeige GORASP1 Proteine) signalling cascade and regulation of the antiapoptosis process in pancreatic cancer cells.
Although CCR2 (zeige CCR2 Proteine) and CX3CR1 may synergistically impact inflammatory phenotypes, their joint deficiency did not influence the metabolic effects of a 45% high-fat diet-induced obesity in these model conditions.
that CX3CL1 (zeige CX3CL1 Proteine)-CX3CR1 signaling is a molecular mechanism capable of modulating microglial-mediated degeneration
Increased fractalkine (zeige CX3CL1 Proteine) and its receptor CX3CR1 may cause a cross-talk between activated glial cells and neurons, playing an important role in the development of neuroinflammation in fructose-fed mice.
CX3CR1 deficiency accelerates the development of vascular pathology in diabetic retinopathy.
CX3CR1(-/-) mice did not become anhedonic in the "two hit" chronic stress paradigm, confirming resistance of these animals to chronic stress-induced mood alterations. However, there was no difference in stress hormone levels, open field performance and hypothalamic microglia distribution between the genotypes. Energy expenditure was increased in CX3CR1(-/-) mice, which may be related to their active coping behavior.
Inflammatory Osteoclasts Prime TNFalpha (zeige TNF Proteine)-Producing CD4 (zeige CD4 Proteine)(+) T Cells and Express CX3 CR1 (zeige TDGF1 Proteine)
our study demonstrates that macrophages expressing a functional CX3CR1 receptor have an important and non-redundant role in controlling the abnormal intestinal inflammation that may lead to tissue damage.
These results highlight the importance of fractalkine (zeige CX3CL1 Proteine)-CX3CR1 interaction in recruitment of macrophages into the brown adipose tissue of obese mice.
Results indicate that deletion of CX3CR1 from microglia under resting conditions modifies brain areas with elevated cellular turnover independent of CX3CL1 (zeige CX3CL1 Proteine).
Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene.
, CX3C chemokine receptor 1
, G protein-coupled receptor 13
, G-protein coupled receptor 13
, beta chemokine receptor-like 1
, chemokine (C-C) receptor-like 1
, chemokine (C-X3-C) receptor 1
, fractalkine receptor
, CX3C chemokine receptor 1-like
, Fractalkine receptor
, chemokine receptor 1
, chemokine (C-X3-C motif) receptor 1