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Human CCL5 Protein expressed in Human Cells - ABIN2003576
Maghazachi, Al-Aoukaty, Schall: CC chemokines induce the generation of killer cells from CD56+ cells. in European journal of immunology 1996
Show all 5 Pubmed References
Breast cancer cell CCL5 mediates bone marrow independent angiogenesis via paracrine signaling.
the present study has demonstrated a novel pathway involving CCl5/CCR1/beta-catenin/Slug, via which human Mesenchymal stem cells promotes colorectal cancer development.
The present study suggest that TT genotype of CCL5 In1.1T/C (rs2280789) polymorphism play an important role to increased CCL5 expression in T cell which may enhanced Th1 (zeige TH1L Proteine) immunity and help in protection against tuberculosis
CSF levels of RANTES were remarkably h (zeige TYMS Proteine)igh only in active multiple sclerosis patients. RANTES levels were associated with tr (zeige SCP2 Proteine)anscranial magnetic stimulation measures of cortical synaptic excitability, but not with long-term potentiation (LTP)-like plasticity.
we document for the first time that CCL5 induces tumor lymphangiogenesis by the induction of VEGF-C (zeige VEGFC Proteine) in human cancer cells
Our findings indicate that the -403 G/A RANTES (CCL5) promoter gene polymorphism is connected with psoriasis vulgaris disease severity.
Baseline serum CCL5 levels and decrease of the serum VEGF-A (zeige VEGFA Proteine) levels may serve as potential predictive markers for survival or treatment-specific toxicities in metastatic colorectal cancer patients receiving regorafenib.
This meta-analysis suggests that RANTES -403G/A and -28C/G polymorphisms confer possible protection against HIV-1 infection, whereas In1.1T/C polymorphism may increase risk of HIV-1 infection, especially in Asians.
CCL5 and CXCL11 (zeige CXCL11 Proteine) expression were also induced in response to the activation of the PKC (zeige PRRT2 Proteine) pathway, and gene silencing experiments indicated that their inducible expression was dependent on RIPK4 (zeige RIPK4 Proteine) and IRF6 (zeige IRF6 Proteine). Moreover, gene reporter assays suggested that RIPK4 (zeige RIPK4 Proteine) induces CCL5 and CXCL11 (zeige CXCL11 Proteine) expression by stimulating the transactivation of their promoters by IRF6 (zeige IRF6 Proteine).
Data suggest that inhibition of CCL5 in adipose microenvironment may represent an approach for the therapy of highly malignant Triple Negative Breast Cancer (TNBC).
Studied the effects of CCL5-CCR5 interactions in breast cancer metabolism, and findings suggest that CCL5-CCR5 interactions in the tumor microenvironment modulate metabolic events during tumor onset to promote tumorigenesis.
RANTES levels were associated with TMS (zeige PYCARD Proteine) measures of cortical synaptic excitability, but not with long-term potentiation (LTP (zeige SCP2 Proteine))-like plasticity.
study found that the inflammatory chemokine (zeige CCL1 Proteine) CCL5 is mostly retained (75%) during the resolution of zymosan A peritonitis in mice; CCL5 exerts a novel proresolving role on macrophages when acting in concert with apoptotic PMN (zeige TBCE Proteine)-expressed D6.
A robust up-regulation of RANTES within the brain was seen in a mouse model of tick-borne encephalitis.
CCL5 paradoxically limits macrophage accumulation in the injured kidney during renin (zeige REN Proteine) angiotensin system (RAS) activation by constraining the proinflammatory actions of CCL2 (zeige CCL2 Proteine).
This study showed that RANTES is important in the regulation of vascular dysfunction through modulation of perivascular inflammation.
IL-6 (zeige IL6 Proteine) Mediates Macrophage Infiltration after Irradiation via Up-regulation of CCL2 (zeige CCL2 Proteine)/CCL5 in Non-small Cell Lung Cancer
Blocking antibodies against RANTES and eotaxin reduced the infiltration of CD4 (zeige CD4 Proteine)(+) and CD8 (zeige CD8A Proteine)(+) T cells into the nigra, attenuated nigral expression of proinflammatory molecules, and suppressed nigral activation of glial cells. These findings paralleled dopaminergic neuronal protection, normalized striatal neurotransmitters, and improved motor functions in MPTP (zeige PTPN2 Proteine)-intoxicated mice.
CCL5 deficiency resulted in reduced neointima formation after carotid artery injury and thrombosis.
These results represent an important molecular mechanism whereby H. parasuis induced RANTES in the inflammatory response.
Foot-and-mouth disease virus leader proteinase inhibits dsRNA-induced RANTES transcription.
we cloned the nucleotide sequence of the 5'-flanking region of the porcine RANTES (poRANTES) gene and characterized the regulatory elements that activate transcription
The Toll (zeige TLR4 Proteine)-like receptor signaling pathway is involved in porcine reproductive and respiratory syndrome virus-induced RANTES activation.
These results suggest that porcine RANTES can play an important role in xenotransplant rejection, through participating in the interaction between porcine endothelial cells and human monocytes.
CCL5 but not CCL2 (zeige CCL2 Proteine) mainly attract bovine classical monocytes and promote their differentiation into LPS (zeige IRF6 Proteine)-hypo-responsive macrophages.
decrease in sensitivity of HIV variants to RANTES neutralization during the course of progressive infection, but not during follow-up of long term survivors; data suggest a role for RANTES neutralization sensitivity of HIV-1 in AIDS pathogenesis
In the pathogenesis of allergic rhinitis, substance P (zeige TAC1 Proteine) induces expression of RANTES in nasal mucosa.
CCL3 (zeige CCL3 Proteine), CCL4 (zeige CCL4 Proteine) and CCL5 gene expression was evaluated in response to simian-human immunodeficiency virus (SHIV) infection in a rhesus macaque model.
This gene is one of several CC cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor.
chemokine (C-C motif) ligand 5
, small inducible cytokine A5
, C-C motif chemokine 5
, T-cell-specific protein RANTES
, regulated upon activation normal T-cell expressed and secreted
, small-inducible cytokine A5
, T-cell specific protein p288
, beta-chemokine RANTES
, eosinophil chemotactic cytokine
, regulated upon activation, normally T-expressed, and presumably secreted
, small inducible cytokine subfamily A (Cys-Cys), member 5
, chemokine ah294
, small inducible cytokine A5 RANTES
, chemokine CCL5/RANTES
, chemokine ligand 5