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Human CCL5 Protein expressed in Human Cells - ABIN2003576
Maghazachi, Al-Aoukaty, Schall: CC chemokines induce the generation of killer cells from CD56+ cells. in European journal of immunology 1996
Show all 5 Pubmed References
Baseline serum CCL5 levels and decrease of the serum VEGF-A (zeige VEGFA Proteine) levels may serve as potential predictive markers for survival or treatment-specific toxicities in metastatic colorectal cancer patients receiving regorafenib.
This meta-analysis suggests that RANTES -403G/A and -28C/G polymorphisms confer possible protection against HIV-1 infection, whereas In1.1T/C polymorphism may increase risk of HIV-1 infection, especially in Asians.
CCL5 and CXCL11 (zeige CXCL11 Proteine) expression were also induced in response to the activation of the PKC (zeige PRRT2 Proteine) pathway, and gene silencing experiments indicated that their inducible expression was dependent on RIPK4 (zeige RIPK4 Proteine) and IRF6 (zeige IRF6 Proteine). Moreover, gene reporter assays suggested that RIPK4 (zeige RIPK4 Proteine) induces CCL5 and CXCL11 (zeige CXCL11 Proteine) expression by stimulating the transactivation of their promoters by IRF6 (zeige IRF6 Proteine).
Data suggest that inhibition of CCL5 in adipose microenvironment may represent an approach for the therapy of highly malignant Triple Negative Breast Cancer (TNBC).
RNA-binding protein (zeige PTBP1 Proteine) HuR (HuR (zeige ELAVL1 Proteine)) expression negatively correlated with chemokine (CC motif) ligand 5 (CCL5) expression and macrophage appearance in a cohort of breast tumors.
we have utilized a broad-scaled affinity proteomics approach to identify three proteins (CCL5, HPGDS (zeige HPGDS Proteine), and NPSR1 (zeige NPSR1 Proteine)) with altered plasma levels in asthmatic children compared to healthy controls, representing the first evaluation of HPGDS (zeige HPGDS Proteine) and NPSR1 (zeige NPSR1 Proteine) in plasma.
Data provide evidence that CCL5 enhances the proliferation and the invasive capacity of human breast cancer cell lines mediated by CCR5 activation.
Cancer-FOXP3 serves as a prognostic biomarker and a crucial determinant of immunosuppressive microenvironment via recruiting Treg cells by directly trans-activating CCL5. Therefore, cancer-FOXP3 could be used to select patients with better response to CCL5/CCR5 blockade immunotherapy.
data suggest that STAT2 (zeige STAT2 Proteine) plays a role in the psoriasis pathogenesis by regulating the expression of CXCL11 (zeige CXCL11 Proteine) and CCL5, and thereby attracting IFNgamma-producing immune cells to the skin
Mean RANTES concentrations in nasal fluid in patients with perennial allergic rhinitis and nonallergic and allergic chronic rhinosinusitis with nasal polyps patients were significantly higher in comparison to control subjects.
study found that the inflammatory chemokine (zeige CCL1 Proteine) CCL5 is mostly retained (75%) during the resolution of zymosan A peritonitis in mice; CCL5 exerts a novel proresolving role on macrophages when acting in concert with apoptotic PMN (zeige TBCE Proteine)-expressed D6.
A robust up-regulation of RANTES within the brain was seen in a mouse model of tick-borne encephalitis.
CCL5 paradoxically limits macrophage accumulation in the injured kidney during renin (zeige REN Proteine) angiotensin system (RAS) activation by constraining the proinflammatory actions of CCL2 (zeige CCL2 Proteine).
This study showed that RANTES is important in the regulation of vascular dysfunction through modulation of perivascular inflammation.
IL-6 (zeige IL6 Proteine) Mediates Macrophage Infiltration after Irradiation via Up-regulation of CCL2 (zeige CCL2 Proteine)/CCL5 in Non-small Cell Lung Cancer
Blocking antibodies against RANTES and eotaxin reduced the infiltration of CD4 (zeige CD4 Proteine)(+) and CD8 (zeige CD8A Proteine)(+) T cells into the nigra, attenuated nigral expression of proinflammatory molecules, and suppressed nigral activation of glial cells. These findings paralleled dopaminergic neuronal protection, normalized striatal neurotransmitters, and improved motor functions in MPTP (zeige PTPN2 Proteine)-intoxicated mice.
CCL5 deficiency resulted in reduced neointima formation after carotid artery injury and thrombosis.
RANTES produced by renal tubular cells act as a key chemokine (zeige CCL1 Proteine) in acute kidney injury and HIF-1alpha (zeige HIF1A Proteine) regulated LncRNA-PRINS might be involved in RANTES production.
Mycobacterium chelonae activates the gene expressions of chemokine (C-C motif) ligand 2 (CCL2 (zeige CCL2 Proteine)) and CCL5 in murine bone marrow-derived macrophages and in vivo mouse model.
Neutralization of circulating RANTES decreased liver neutrophilic infiltration
These results represent an important molecular mechanism whereby H. parasuis induced RANTES in the inflammatory response.
Foot-and-mouth disease virus leader proteinase inhibits dsRNA-induced RANTES transcription.
we cloned the nucleotide sequence of the 5'-flanking region of the porcine RANTES (poRANTES) gene and characterized the regulatory elements that activate transcription
The Toll (zeige TLR4 Proteine)-like receptor signaling pathway is involved in porcine reproductive and respiratory syndrome virus-induced RANTES activation.
These results suggest that porcine RANTES can play an important role in xenotransplant rejection, through participating in the interaction between porcine endothelial cells and human monocytes.
CCL5 but not CCL2 (zeige CCL2 Proteine) mainly attract bovine classical monocytes and promote their differentiation into LPS (zeige IRF6 Proteine)-hypo-responsive macrophages.
decrease in sensitivity of HIV variants to RANTES neutralization during the course of progressive infection, but not during follow-up of long term survivors; data suggest a role for RANTES neutralization sensitivity of HIV-1 in AIDS pathogenesis
In the pathogenesis of allergic rhinitis, substance P (zeige TAC1 Proteine) induces expression of RANTES in nasal mucosa.
CCL3 (zeige CCL3 Proteine), CCL4 (zeige CCL4 Proteine) and CCL5 gene expression was evaluated in response to simian-human immunodeficiency virus (SHIV) infection in a rhesus macaque model.
This gene is one of several CC cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor.
chemokine (C-C motif) ligand 5
, small inducible cytokine A5
, C-C motif chemokine 5
, T-cell-specific protein RANTES
, regulated upon activation normal T-cell expressed and secreted
, small-inducible cytokine A5
, T-cell specific protein p288
, beta-chemokine RANTES
, eosinophil chemotactic cytokine
, regulated upon activation, normally T-expressed, and presumably secreted
, small inducible cytokine subfamily A (Cys-Cys), member 5
, chemokine ah294
, small inducible cytokine A5 RANTES
, chemokine CCL5/RANTES
, chemokine ligand 5