Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
apoA-II (zeige APOA2 Proteine) enhanced ABCA1-mediated cholesterol efflux
Cholesterol efflux from THP-1 macrophages is decreased in the presence of plasma obtained from humans and rats with mild hyperbilirubinemia. A direct effect of unconjugated bilirubin on cholesterol efflux was demonstrated and is associated with decreased ABCA1 protein expression.
identified HuR (zeige ELAVL1 Proteine) as a novel posttranscriptional regulator of ABCA1 expression and cellular cholesterol homeostasis, thereby opening new avenues for increasing cholesterol efflux from atherosclerotic foam macrophages and raising circulat-ing HDL (zeige HSD11B1 Proteine) cholesterol levels.
Hepatic ABCA1 deficiency results in increased hepatic triglyceride and ANGPTL3 (zeige ANGPTL3 Proteine) secretion, potentially underlying the elevated plasma triglyceride levels in Tangier disease patients.
ABCA1-derived nascent high-density lipoprotein-apolipoprotein AI (zeige APOA1 Proteine) and lipids metabolically segregate.
Hepatic free cholesterol content was significantly increased in NASH (zeige SAMSN1 Proteine) as compared to non-NASH (zeige SAMSN1 Proteine) subjects, while ABCA1 and ABCG1 (zeige ABCG1 Proteine) protein levels significantly decreased with NASH (zeige SAMSN1 Proteine) and fibrosis progression. The relative expression of miR (zeige MLXIP Proteine)-33a and miR (zeige MLXIP Proteine)-144 correlated inversely with ABCA1 but not with ABCG1 (zeige ABCG1 Proteine) protein levels. miR (zeige MLXIP Proteine)-33a/144 and their target gene ABCA1 may contribute to the pathogenesis of NASH (zeige SAMSN1 Proteine) in morbidly obese subjects.
Understanding the relationship between cholesterol and inflammation in the lung, and the role that ABC (zeige ABCB6 Proteine) transporters play in this may illuminate new pathways to target for the treatment of inflammatory lung diseases
ABCA1 was mainly located on trophoblast membranes. Decreased ABCA1 expression in trophoblasts reduced the cholesterol efflux of trophoblasts (P < 0.01). while increased ABCA1 expression in trophoblasts reduced the cholesterol efflux of trophoblasts (P < 0.05). ABCA1 was uniformly expressed on the cell membrane, cytoplasm, and nucleus of macrophages.
AMPK (zeige PRKAA1 Proteine) activates LXRalpha (zeige NR1H3 Proteine) and ABCA1 expression in human macrophages
Microparticles are lipoprotein-sized structures created by the ABCA1 transporter, and contribute approximately 30% of ABCA1-and apoA-I (zeige APOA1 Proteine) mediated cholesterol efflux. MPs release from cells consists, in part, of exosomes and depends on the same pathway used for HDL (zeige HSD11B1 Proteine) biogenesis.
our results highlight the importance of the LXR (zeige NR1H3 Proteine)/ABCA1 system in brain pericytes and suggest a new role for these cells in brain cholesterol homeostasis.
The expression and distribution of the bovine ABCA1 transporter using quantitative PCR and the sequencing of the entire ABCA1 coding region, including the proximal promoter region, are reported.
Aortic endothelial cells transcytose high-density lipoproteins by mechanisms that involve either SR-BI (zeige SCARB1 Proteine) or ABCG1 (zeige ABCG1 Proteine) but not ABCA1.
ABCA1 promoter variants affect transcription activity and plasma HDL (zeige HSD11B1 Proteine) level in pigs
ABCA1 was up-regulated in monocytes of hypercholesterolemic pigs via oxidized-LDL and prior to development coronary atherosclerosis.
Both region-specific and ubiquitous (ABCA1) phenotype changes were identified as early prelesional responses of the endothelium to hypercholesterolemia
CSL112 elevation of ABCA1-dependent efflux may target atherosclerotic plaque for cholesterol removal.
(1) ABCA1 maintains optimal hepatocyte PM FC, through intracellular FC trafficking, for efficient insulin (zeige INS Proteine) signaling; and (2) hepatocyte ABCA1 deletion produces a form of selective insulin (zeige INS Proteine) resistance so that lipogenesis is suppressed but glucose metabolism remains normal
demonstrates behavior deficits caused by Abca1 deletion in APP (zeige APP Proteine)/PS1DeltaE9 mouse model at an early stage of amyloid pathology. The basal deficits of Abca1ko, manifested by diminished cognitive performance, prevent them from coping with additional stressors, which is in part due to the impairment of neurite morphology in the hippocampus.
Rutaecarpine was identified to be a candidate that protected ApoE (zeige APOE Proteine)(-/-) mice from developing atherosclerosis through preferentially promoting activities of ABCA1 and SR-BI (zeige SCARB1 Proteine) within RCT (zeige FOXE3 Proteine).
Abca1 has a protective role in atherosclerosis, it exerts detrimental effects on cardiac function after myocardial infarction
Caveolin-1 (zeige CAV1 Proteine) enhances internalization and degradation of ABCA1 by its association with ABCA1
an important role for hepatic ABCA1 in regulating secretory trafficking and modulating VLDL expansion during the TG accretion phase of hepatic lipoprotein particle assembly
These studies showed that following brain ischemia, reactive astrocytes become phagocytic and engulf debris via the ABCA1 pathway.
PCSK9 (zeige PCSK9 Proteine) plays a direct role on Abca1-mediated cholesterol efflux through a downregulation of Abca1 gene and Abca1 protein expression. This extrahepatic effect may influence relevant steps in the pathogenesis of atherosclerosis, such as foam cell formation.
apoA-I (zeige APOA1 Proteine)/ABCA1-mediated cholesterol efflux without STAT3 (zeige STAT3 Proteine) activation can reduce proinflammatory cytokine expression in macrophages.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.
ATP-binding cassette sub-family A member 1
, ATP-binding cassette transporter A1
, cholesterol efflux regulatory protein
, ATP-binding cassette, sub-family A (ABC1), member 1
, ATP-binding cassette, sub-family A member 1
, ATP-binding cassette transporter 1
, Cholesterol efflux regulatory protein
, ATP-binding cassette transporter
, ATP-binding cassette, sub-family A member 1-like
, ATP-binding cassette sub-family A member 1-like
, ATP-binding cassette 1