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nectin-4 serves as a stimulatory co-receptor for the prolactin receptor (zeige PRLR Proteine) by regulating the feedback inhibition of SOCS1 (zeige SOCS1 Proteine) in the JAK2 (zeige JAK2 Proteine)-STAT5a (zeige STAT5A Proteine) signaling pathway
Novel type of cell adhesion apparatus is mediated by Nectin-1 (zeige PVRL1 Proteine) and Nectin-4. It's implicated in prolactin receptor (zeige PRLR Proteine) signaling for mammary gland development.
Pvrl1 (zeige PVRL1 Proteine) is a bona fide target gene of the transcription factor p63 (zeige CKAP4 Proteine), whereas Pvrl4 regulation is linked to epidermal differentiation and is under Irf6 (zeige IRF6 Proteine)
Mouse PVRL4 functions less efficiently as a receptor for measles virus than the human homologue.
Ectodermal dysplasia-syndactyly syndrome is the second known "nectinopathy" caused by mutations in a nectin (zeige PVRL1 Proteine) adhesion molecule (zeige NCAM1 Proteine).
Nectin-4 promotes cell-cell adhesion/aggregation, migration, and proliferation of ovarian tumor cells.
Nectin-4 is not only a BCSC marker but also a breast cancer metastasis marker
This study suggests that PVRL4 is post-transcriptionally regulated by miR (zeige MLXIP Proteine)-128 and miR (zeige MLXIP Proteine)-31.
High Nectin-4 expression is associated with neoplasms.
We show that Measles virus gains entry into MCF7, DLD (zeige DLD Proteine)-1, and HTB-20 cancer cells through a PVRL4-mediated macropinocytosis pathway and identified the typical cellular GTPase (zeige RACGAP1 Proteine) and kinase involved.
Nectin-4 is both a new promising prognostic biomarker and specific therapeutic target for Triple-negative breast cancers
ADAM17 (zeige ADAM17 Proteine) and ADAM10 (zeige ADAM10 Proteine) cleave Nectin-4 and release soluble Nectin-4 (sN4).
The data presented in this study suggested that nectin-4 may be a therapeutic target for systemic lupus erythematous through affecting the cell apoptosis
Nectin-4 is critical for gallbladder cancer cell progression via PI3K/AKT pathway activation of Rac1.
This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.
poliovirus receptor-related 4
, poliovirus receptor-related protein 4-like
, ig superfamily receptor LNIR
, nectin 4
, poliovirus receptor-related protein 4
, Ig superfamily receptor LNIR