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PAK4 (zeige PAK4 Proteine) phosphorylates Par6B at Ser143 blocking its interaction with Cdc42 (zeige CDC42 Proteine).
Pard6b is necessary for blastocyst morphogenesis
reduced expression of PKCzeta (zeige PRKCZ Proteine)/Pard3 (zeige PARD3 Proteine)/Pard6 contributes to non-small-cell lung cancer epithelial-mesenchymal transition, invasion, and chemoresistance.
found that the polarity determinants Cdc42 (zeige CDC42 Proteine), Par6B, PKCzeta (zeige PRKCZ Proteine)/iota and the structural proteins ezrin (zeige EZR Proteine) and phospho-ezrin (zeige EZR Proteine) were lost from the apical membrane and accumulated either in the cytoplasm or on the basal side of enterocytes in patients
Data conclude that Par6B and aPKC control mitotic spindle orientation in polarized epithelia and, furthermore, that aPKC coordinately regulates multiple processes to promote morphogenesis.
This study demonstrates that controlled regulation of PAK4 (zeige PAK4 Proteine) is required for apical junction formation in lung epithelial cells and highlights potential cross-talk between two Cdc42 (zeige CDC42 Proteine) targets, PAK4 (zeige PAK4 Proteine) and Par6B.
The ability of SRC (zeige SRC Proteine) family coactivators to regulate the expression of one of these genes, PARD6B/Par6, was confirmed by using cells individually depleted of SRC-1 (zeige SRC Proteine).
Interaction between PAR-3 (zeige F2RL2 Proteine) and the aPKC-PAR-6 (zeige PARD6A Proteine) complex is indispensable for apical domain development of epithelial cells.
Data indicate that the polarity protein Partitioning defective-6 homolog beta (Par6b) regulates not only the dynamics of apicobasal polarity but also integrity of the developing stratified epidermis.
ephrinB1 (zeige EFNB1 Proteine) associates with the Par (zeige AFG3L2 Proteine) polarity complex protein Par-6 (zeige PARD6A Proteine) and can compete with the small GTPase (zeige RACGAP1 Proteine) Cdc42 (zeige CDC42 Proteine) for association with Par-6.
This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex.
par-6 partitioning defective 6 homolog beta (C. elegans)
, PAR-6 beta
, partitioning defective 6 homolog beta
, partitioning-defective protein 6, beta
, par-6 partitioning defective 6 homolog beta
, partitioning defective 6 beta