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Here the authors identify neuron-specific intercellular adhesion molecule 5 (ICAM-5/telencephalin) as a cellular receptor for sialic acid-dependent and -independent entry of enterovirus D68.
ICAM5 V301I and rs281439 variants may contribute to the susceptibility of breast cancer. [Meta-analysis]
A specific microenvironment facilitating ARF6 (zeige ARF6 Proteine)-mediated mobilization of TLN that contributes to promotion of dendritic spine development.
study does not confirm association between ICAM 5 V3001 polymorphism and breast cancer risk
ICAM-5 is involved in immune privilege of the brain and acts as an anti-inflammatory agent.
Data show that estradiol or bisphenol A decreased expression of luteinizing hormone beta (Lhb (zeige LHB Proteine)), follicle stimulating hormone beta (Fshb (zeige FSHB Proteine)), and intracellular adhesion molecule (zeige NCAM1 Proteine)-5 (Icam5) in females but only decreased expression of Icam5 in males.
This study revealed a similar expression of ICAM-5 in dendritic elements at P14 (zeige PCOLCE Proteine) and P28 (zeige GSTO1 Proteine); however, an increased prevalence of ICAM-5 was noted in dendritic protrusions at P28 (zeige GSTO1 Proteine) in the MMP-9 (zeige MMP9 Proteine) null animals
Results suggest that the interaction between ICAM-5 and beta1 integrins is important in formation of functional synapses.
MMPs and soluble ICAM-5 increase neuronal excitability
the extracellular matrix molecule VN and its neuronal receptor TLCN play a pivotal role in the phosphorylation of ezrin/radixin/moesin (zeige MSN Proteine) proteins and the formation of phagocytic cup-like structures on neuronal dendrites
analysis of activated apoptotic cells induce dendritic cell maturation via engagement of Toll-like receptor 4 (TLR4 (zeige TLR4 Proteine)), dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3 (zeige ICAM3 Proteine))-grabbing nonintegrin (DC-SIGN (zeige CD209 Proteine)), and beta2 integrins
A novel serine-rich motif in the intercellular adhesion molecule 3 (zeige ICAM3 Proteine) is critical for its ezrin/radixin/moesin (zeige MSN Proteine)-directed subcellular targeting
Collectively, PS1 (zeige PSEN1 Proteine) deficiency affects in a gamma-secretase-independent fashion the turnover of telencephalin through autophagic vacuoles, most likely by an impaired capability to fuse with lysosomes.
Study defines a physiological mechanism for the proteolytic processing of ICAM-5 by MMP-2 (zeige MMP2 Proteine) and MMP-9 (zeige MMP9 Proteine) and the importance of the its cleavage on regulation of dendritic spine development.
Our results suggest that ICAM-5 plays a critical role in modulating chemokine (zeige CCL1 Proteine) production in the CNS.
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases.
, intercellular adhesion molecule 5
, intercellular adhesion molecule 3
, LOW QUALITY PROTEIN: intercellular adhesion molecule 5
, intercellular adhesion molecule 5, telencephalin
, intercellular adhesion molecule 5 L homeolog