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IHC of SSTR (zeige SSTR3 Proteine) subtypes in the different cohorts showed SSTR2 (zeige SSTR2 Proteine) staining intensity scores higher than SSTR5 in TSHoma, acromegaly and prolactinoma, whereas the expression of SSTR5 was stronger than SSTR2 (zeige SSTR2 Proteine) in corticotropinoma and NFPA.
Somatostatin receptor 5 variant (sst5TMD4) was expressed in a subset of breast cancers, where it correlated with angiogenic markers, lymphatic metastasis, and reduced disease-free survival.
sst5TMD4 is overexpressed in PCa (zeige FLVCR1 Proteine), especially in those patients with a worse prognosis, and plays an important pathophysiologic role in PCa (zeige FLVCR1 Proteine), which suggesting its potential as a biomarker and/or therapeutic target
In cotransfected HEK (zeige EPHA3 Proteine)-293 cells, SSTR5 and CB1R (zeige CNR1 Proteine) existed in a constitutive heteromeric complex under basal condition, which was disrupted upon agonist treatments. Furthermore, concurrent receptor activation led to preferential formation of SSTR5 homodimer and dissociation of CB1R (zeige CNR1 Proteine) homodimer.
Combination treatment increased both SSTR2 (zeige SSTR2 Proteine) and SSTR5 mRNA and protein levels in DU-145 cells. The data suggest that this combination therapy may be a good candidate for patients with advanced metastatic Prostate cancer (PCa (zeige FLVCR1 Proteine)) do not respond to androgen deprivation.
A truncated splice variant of the somatostatin receptor subtype 5, is associated to features of increased aggressiveness in pancreatic neuroendocrine tumors.
SSTR5 was the predominantly expressed receptor subtype in the cytoplasm of all GH-secreting adenomas tested, regardless of whether they came from octreotide-naive, octreotide-responsive, or octreotide-resistant patients. SSTR5 mRNA predominance was significant only in octreotide treated patients. Its expression was not correlated with baseline or post-octreotide GH or IGF-1 (zeige IGF1 Proteine) levels or tumor volume.
Data showed that the distribution of somatostatin (zeige SST Proteine) receptor (SSTR (zeige SSTR3 Proteine)) subtypes among the 199 pancreatic neuroendocrine tumors (PNETs) was: SSTR2 (zeige SSTR2 Proteine) (54.8%), SSTR1 (zeige SSTR1 Proteine) (53.3%), SSTR4 (51.8%), SSTR5 (33.7%), and SSTR3 (zeige SSTR3 Proteine) (28.6%).
Data indicate that somatostatin (zeige SST Proteine) receptor scintigraphy (SRS (zeige SMS Proteine)) and immunohistochemical results for somatostatin (zeige SST Proteine) and dopamine receptors sstr2 (zeige SSTR2 Proteine), sstr3 (zeige SSTR3 Proteine), sstr5 and D2R (zeige DRD2 Proteine) were compared in neuroendocrine neoplasms tissues.
Somatostatin (zeige SST Proteine) receptors were expressed in a high proportion of merkel cell carcinomas, although expression was heterogeneous between tumours and was not associated with disease severity.
The expression and localization of the three receptors (SSTR3 (zeige SSTR3 Proteine)-SSTR5) in wild-type (WT), single-knockout (SSTR1 (zeige SSTR1 Proteine) KO) and double-knockout SSTR1 (zeige SSTR1 Proteine)/SSTR2 (zeige SSTR2 Proteine) (DKO) mice, are reported.
mouse somatostatin receptor 5 is sorted by a network of PDZ-domain containing proteins
Findings suggest that somatostatin (zeige SST Proteine) and its receptors (SSTR2 (zeige SSTR2 Proteine) and SSTR5) are important markers in the regulation and development of Sertoli cell.
In comparison to wt, ApoD (zeige APOD Proteine)(-/-) mice exhibit increased SSTR5-like immunoreactivity in paraventricular nuclei and decreased receptor expression in ventromedial hypothalamus and arcuate nucleus.
Somatostatin (zeige SST Proteine) inhibited GIP (zeige GIP Proteine) and glucagon-like peptide-1 (GLP-1 (zeige GCG Proteine)) secretion from primary small intestinal cultures, in part through SSTR5.
SSTR5 is a negative regulator for PDX-1 (zeige PDX1 Proteine) expression and SSTR5 may mediate the inhibitory effects of somatostatin (zeige SST Proteine) and its analogs on insulin (zeige INS Proteine) expression/secretion and cell proliferation via down-regulating PDX-1 (zeige PDX1 Proteine)
SST (zeige SST Proteine) and SSTRs might play an important role in regulation of neurodegeneration
The existence of new truncated sst5-variants with unique ligand-selective signaling properties, which could contribute to further understanding the complex, distinct pathophysiological roles of somatostatin (zeige SST Proteine) and cortistatin (zeige CORT Proteine).
Extraovarian somatostatin (zeige SST Proteine), acting through its receptors 2 and 5 present on granulosa cells, may be involved in mouse folliculogenesis by reducing recruitment of resting follicles.
The effect of sst2 (zeige SSTR2 Proteine) receptor knockout on sst5 receptor mRNA localization and binding sites throughout the brain has been determined.
This study describes the cloning and characterization of procine sst5 and identifies two spliced variants with six and three transmembrane domains (TMD (zeige TTN Proteine)): psst5TMD6 and psst5TMD3; psst5TMD6 and psst5TMD3 are functional (e.g., activate calcium signaling.
Data demonstrate that urotensin II (zeige UTS2 Proteine) and urotensin II-related peptide directly activate somatostatin (zeige SST Proteine) receptors 2 and 5 and thus mimic the effect of somatostatin (zeige SST Proteine) on its cognate receptors.
Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene.
somatostatin receptor type 5
, somatostatin receptor 5
, somatostatin receptor subtype 5
, Somatostatin receptor subtype 5