anti-Dopamine Receptor d1 (DRD1) Antikörper

Rabbit Dopamine Receptor D1 (DRD1) Interaktionspartner

1. In vivo and in vitro results confirm that D1 receptors and not D2 are the ones that mediate the role of dopamine in the control of penile erection peripherally.

Cow (Bovine) Dopamine Receptor D1 (DRD1) Interaktionspartner

1. There were significant differences in the allelic frequencies among Bos taurus and Bos indicus breeds of different temperament for the DRD1, DRD4, and DRD5 markers.

Human Dopamine Receptor D1 (DRD1) Interaktionspartner

1. DRD1 protein is highly expressed in glioma tissues. The proliferation, migration and invasion abilities were enhanced by DRD1-mediated cAMP pathway in U87 cells.

2. Study results supported the hypothesis that DRD2 affected risperidone treatment. DRD1 had no significant effect on the response to risperidone, whereas DRD3 might be associated with an improvement in negative symptoms. [systematic review and meta-analysis]

3. Striatal D1-type but not D2-type BPnd was negatively associated with global mean cortical gray-matter thickness in the methamphetamine group, but no association was found between gray-matter thickness and BPnd for either dopamine receptor subtype in the control group. These results suggest a role of striatal D1-type receptors in cortical adaptation to chronic methamphetamine use.

4. activation of the dopamine D1 receptor on human airway epithelium could induce mucus overproduction, which could worsen airway obstructive symptoms.

5. The promoter region of DRD1 corresponded to positions - 1250 to + 250 in the DNA sequence. The transcription factor-binding sequence was localized.

6. Greater DRD1-related coexpression was associated with lower prefrontal activity and higher working memory performance, indicating greater working memory efficiency.

7. Molecular dynamics simulations show that the interaction of dopamine with the D1 receptor leads to the formation of a hydrogen-bond network with its catechol group and helices 3, 5, and 6, including water molecules. The para hydroxyl group of dopamine binds directly to S5.42 and N6.55, the latter also interacting with S5.43. The formation of this hydrogen-bond network, triggers the opening of the E6.30-R3.60 ionic lock.

8. Two SUMO modification sites existed in dopamine receptor D1, the phosphorylation of which, due to SUMO modification, can interact with PP2A, leading to the inhibition of D1 de-phosphorylation and normal function.

9. Nucleus accumbens dopamine-dopamine receptor signaling regulates sexual preference for females in male mice via Trpc2.

10. childhood urbanicity and variation in dopamine genes COMT, DRD1 and DRD2 alters adult prefrontal function as measured by fMRI

11. Positron emission tomography data showed strong to moderate evidence in favor of failed replications of correlations between D1-R availability and trait social desirability or physical aggression.

12. DR1 induces osteosarcoma cell apoptosis via changes to the MAPK pathway

13. Synonymous SNPs (rs1799914 and rs4867798) of the DRD1 gene were associated with Essential Hypertension in Hani nationality However, none SNPs of DRD1 and DRD3 of best models showed association with Essential Hypertension in Han and Yi nationality.

14. study to identify putative genetic factors in genes of serotonergic and dopaminergic systems modulating the level of manifestation of depressive symptoms in children; a significant interaction effect was detected between rs1039089 in conjunction with rs877138 located upstream of DRD1 and DRD2 genes respectively

15. D1 receptor system is associated with pre-motor inhibition electrophysiological correlates of response inhibition processes

16. DRD1, DRD2 and DRD3 may not be the susceptibility genes for schizophrenia in the Chinese Han population.

17. the D1 receptor exists in several different membrane localizations, depending on the receptor's conformation.

18. D1 receptor is involved in mediating the epileptic effects of Abeta1-42.

19. Signaling of dopamine receptor D1 is regulated by VPS35.

20. The Parkinson's disease-associated LRRK2 mutant G2019S impairs DRD1 internalization, leading to an alteration in signal transduction. The mutant forms of LRRK2 also affect receptor turnover by decreasing the rate of DRD2 trafficking from the Golgi complex to the cell membrane.

Horse (Equine) Dopamine Receptor D1 (DRD1) Interaktionspartner

1. The amount of dopamine d1 receptor, dopamine D2 receptor, and follicle stimulating hormone receptor (FSHr) mRNA were quantified in ovarian tissues in anestrous and mares expressing estrus during the breeding season are reported.

Pig (Porcine) Dopamine Receptor D1 (DRD1) Interaktionspartner

1. The results suggest that endocytosis of beta(1)-adrenoceptor in renal proximal tubular cells is an important step in signal generation, while endocytosis of proximal tubular D1 receptor is not.

Rhesus Monkey Dopamine Receptor D1 (DRD1) Interaktionspartner

1. Study shows that blocking dopamine D1Rs or stimulating dopamine D2Rs increased low-frequency theta and alpha oscillations known to be involved in learning and memory. In contrast, only D1R inhibition enhanced high-frequency beta oscillations, whereas only D2R stimulation increased gamma oscillations linked to top-down and bottom-up attentional processing.

2. findings highlight complementary modulatory contributions of dopamine d1 & d2 receptors to the neuronal circuitry mediating executive functioning and goal-directed behavior.

3. these data provide evidence that functional D1/D5 receptors are expressed in the internal globus pallidus and the substantia nigra pars reticulata in both normal and parkinsonian states in monkeys

Mouse (Murine) Dopamine Receptor D1 (DRD1) Interaktionspartner

1. Results suggest that the activation of the dopamine D1 receptor plays a critical role in the persistence of long-term spatial memory through the PKA signaling pathway.

2. Results provide evidence that innate general cognitive abilities are related to D1 receptor turnover rates in the prefrontal cortex, and that an intracellular pool of immature D1 receptors are available to accommodate cognitive demands.

3. Study found that D1 receptor activation reduced the amplitude of electrically evoked responses, showing that D1 receptors can modulate amacrine cells directly. Results suggest that D1 receptor activation can replicate a large portion but not all of the effects of light adaptation, likely by modulating release from amacrine cells onto rod bipolar cells.

4. Intervention of D1 dopamine receptor functions or the signaling pathways-related D1 receptors in D2 Knockout mice produced anti-autistic effects.

5. Mc4r and Drd1a can serve as surrogate odorant receptors in mouse olfactory sensory neurons

6. D1/D2 medium spiny neurons in the mouse striatum form a distinct neuronal population that is affected differently by dopamine deafferentation that characterizes Parkinson's disease.

7. These results suggested that D1R has versatile functions, and the knockdown timing greatly influences the normal motor activity in the adolescent to adult stages.

8. Heroin-induced impulsive behavior in the 5-choice serial reaction time task is oppositely modulated by D1 and D3 receptor activation.

9. This study explored the spatial distribution of D1 medium-sized spiny neurons across the rostral-caudal axis of the striatum using D1-tdTomato double transgenic mice.

10. Wiskott-Aldrich syndrome protein family (WAVE1) knocked out (KO) in neurons expressing the D1 dopamine receptor (D1-KO) exhibited a significant decrease in place preference associated with cocaine.

11. Study indicates that dopamine D1Rs are expressed by different classes of interneurons in all layers examined and not by pyramidal cells, suggesting that hippocampus CA1 D1R mostly acts via modulation of GABAergic interneurons.

12. Findings show that dopamine D1/5 receptor activation is a target for the enhancement of fear or reward extinction.

13. Study shows that dopamine and the dopamine receptor D1 are associated with decreased social interaction

14. Study shows that suppression of striatal dopamine D1 receptors selectively impaired reward-associative learning whereas punishment-associative learning, aversion-motivated learning, and appetitive motivation were spared

15. Dopamine D1 receptor-expressing cells in the hippocampus contribute to cocaine conditioned place preference extinction.

16. Localization of the dopamine receptors of types 1 and 2 on the bodies of POMC-expressing neurons of the arcuate nucleus of the hypothalamus in mice and rats.

17. Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration

18. Results show that deleted in colorectal cancer receptors contribute to the dynamic refinement of dopamine D1 and D2 receptor expression in striatal regions across adolescence. The age-dependent expression of dopamine receptor in C57BL6 mice shows marked differences from previous characterizations in rats.

19. Salicylate-induced tinnitus may be associated with increased mRNA expression of the DR1A gene - but with decreased mRNA expression of the CR1 gene - in the cochlea and in many tinnitus-related brain areas.

20. The Parkinson's disease-associated LRRK2 mutant G2019S impairs DRD1 internalization, leading to an alteration in signal transduction. The mutant forms of LRRK2 also affect receptor turnover by decreasing the rate of DRD2 trafficking from the Golgi complex to the cell membrane.

Guinea Pig Dopamine Receptor D1 (DRD1) Interaktionspartner

1. Dopamine D1 receptor play role in memory consolidation.