anti-Dopamine Receptor d1 (DRD1) Antikörper

Rabbit Dopamine Receptor D1 (DRD1) Interaktionspartner

1. In vivo and in vitro results confirm that D1 receptors and not D2 are the ones that mediate the role of dopamine in the control of penile erection peripherally.

Cow (Bovine) Dopamine Receptor D1 (DRD1) Interaktionspartner

1. There were significant differences in the allelic frequencies among Bos taurus and Bos indicus breeds of different temperament for the DRD1, DRD4, and DRD5 markers.

Human Dopamine Receptor D1 (DRD1) Interaktionspartner

1. activation of the dopamine D1 receptor on human airway epithelium could induce mucus overproduction, which could worsen airway obstructive symptoms.

2. The promoter region of DRD1 corresponded to positions - 1250 to + 250 in the DNA sequence. The transcription factor-binding sequence was localized.

3. Greater DRD1-related coexpression was associated with lower prefrontal activity and higher working memory performance, indicating greater working memory efficiency.

4. Molecular dynamics simulations show that the interaction of dopamine with the D1 receptor leads to the formation of a hydrogen-bond network with its catechol group and helices 3, 5, and 6, including water molecules. The para hydroxyl group of dopamine binds directly to S5.42 and N6.55, the latter also interacting with S5.43. The formation of this hydrogen-bond network, triggers the opening of the E6.30-R3.60 ionic lock.

5. Two SUMO modification sites existed in dopamine receptor D1, the phosphorylation of which, due to SUMO modification, can interact with PP2A, leading to the inhibition of D1 de-phosphorylation and normal function.

6. Nucleus accumbens dopamine-dopamine receptor signaling regulates sexual preference for females in male mice via Trpc2.

7. childhood urbanicity and variation in dopamine genes COMT, DRD1 and DRD2 alters adult prefrontal function as measured by fMRI

8. Positron emission tomography data showed strong to moderate evidence in favor of failed replications of correlations between D1-R availability and trait social desirability or physical aggression.

9. DR1 induces osteosarcoma cell apoptosis via changes to the MAPK pathway

10. Synonymous SNPs (rs1799914 and rs4867798) of the DRD1 gene were associated with Essential Hypertension in Hani nationality However, none SNPs of DRD1 and DRD3 of best models showed association with Essential Hypertension in Han and Yi nationality.

11. study to identify putative genetic factors in genes of serotonergic and dopaminergic systems modulating the level of manifestation of depressive symptoms in children; a significant interaction effect was detected between rs1039089 in conjunction with rs877138 located upstream of DRD1 and DRD2 genes respectively

12. D1 receptor system is associated with pre-motor inhibition electrophysiological correlates of response inhibition processes

13. DRD1, DRD2 and DRD3 may not be the susceptibility genes for schizophrenia in the Chinese Han population.

14. the D1 receptor exists in several different membrane localizations, depending on the receptor's conformation.

15. D1 receptor is involved in mediating the epileptic effects of Abeta1-42.

16. Signaling of dopamine receptor D1 is regulated by VPS35.

17. The Parkinson's disease-associated LRRK2 mutant G2019S impairs DRD1 internalization, leading to an alteration in signal transduction. The mutant forms of LRRK2 also affect receptor turnover by decreasing the rate of DRD2 trafficking from the Golgi complex to the cell membrane.

18. Here, using PET with [(11)C]raclopride, we identified in the AKT1 gene a new variable number tandem repeat (VNTR) marker associated with baseline striatal dopamine D2/D3 receptor availability and with methylphenidate-induced striatal dopamine increases in healthy volunteers.

19. We explore the role of mothers' executive function in mediating the relation between oxytocin and dopamine gene variants and maternal responsiveness and examined single nucleotide polymorphisms (SNPs) related to the dopamine system DRD1 rs686, DRD1 rs265976,. Dopamine SNPs were not associated with any measure of executive function or parenting (all P > 0.05).

20. DRD1 gene polymorphisms are related to heroin dependence in a Chinese Han population and may be informative for future genetic or biological studies on heroin dependence.

Horse (Equine) Dopamine Receptor D1 (DRD1) Interaktionspartner

1. The amount of dopamine d1 receptor, dopamine D2 receptor, and follicle stimulating hormone receptor (FSHr) mRNA were quantified in ovarian tissues in anestrous and mares expressing estrus during the breeding season are reported.

Pig (Porcine) Dopamine Receptor D1 (DRD1) Interaktionspartner

1. The results suggest that endocytosis of beta(1)-adrenoceptor in renal proximal tubular cells is an important step in signal generation, while endocytosis of proximal tubular D1 receptor is not.

Rhesus Monkey Dopamine Receptor D1 (DRD1) Interaktionspartner

1. findings highlight complementary modulatory contributions of dopamine d1 & d2 receptors to the neuronal circuitry mediating executive functioning and goal-directed behavior.

2. these data provide evidence that functional D1/D5 receptors are expressed in the internal globus pallidus and the substantia nigra pars reticulata in both normal and parkinsonian states in monkeys

Mouse (Murine) Dopamine Receptor D1 (DRD1) Interaktionspartner

1. Mc4r and Drd1a can serve as surrogate odorant receptors in mouse olfactory sensory neurons

2. D1/D2 medium spiny neurons in the mouse striatum form a distinct neuronal population that is affected differently by dopamine deafferentation that characterizes Parkinson's disease.

3. These results suggested that D1R has versatile functions, and the knockdown timing greatly influences the normal motor activity in the adolescent to adult stages.

4. Heroin-induced impulsive behavior in the 5-choice serial reaction time task is oppositely modulated by D1 and D3 receptor activation.

5. This study explored the spatial distribution of D1 medium-sized spiny neurons across the rostral-caudal axis of the striatum using D1-tdTomato double transgenic mice.

6. Wiskott-Aldrich syndrome protein family (WAVE1) knocked out (KO) in neurons expressing the D1 dopamine receptor (D1-KO) exhibited a significant decrease in place preference associated with cocaine.

7. Study indicates that dopamine D1Rs are expressed by different classes of interneurons in all layers examined and not by pyramidal cells, suggesting that hippocampus CA1 D1R mostly acts via modulation of GABAergic interneurons.

8. Findings show that dopamine D1/5 receptor activation is a target for the enhancement of fear or reward extinction.

9. Study shows that dopamine and the dopamine receptor D1 are associated with decreased social interaction

10. Study shows that suppression of striatal dopamine D1 receptors selectively impaired reward-associative learning whereas punishment-associative learning, aversion-motivated learning, and appetitive motivation were spared

11. Dopamine D1 receptor-expressing cells in the hippocampus contribute to cocaine conditioned place preference extinction.

12. Localization of the dopamine receptors of types 1 and 2 on the bodies of POMC-expressing neurons of the arcuate nucleus of the hypothalamus in mice and rats.

13. Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration

14. Results show that deleted in colorectal cancer receptors contribute to the dynamic refinement of dopamine D1 and D2 receptor expression in striatal regions across adolescence. The age-dependent expression of dopamine receptor in C57BL6 mice shows marked differences from previous characterizations in rats.

15. Salicylate-induced tinnitus may be associated with increased mRNA expression of the DR1A gene - but with decreased mRNA expression of the CR1 gene - in the cochlea and in many tinnitus-related brain areas.

16. The Parkinson's disease-associated LRRK2 mutant G2019S impairs DRD1 internalization, leading to an alteration in signal transduction. The mutant forms of LRRK2 also affect receptor turnover by decreasing the rate of DRD2 trafficking from the Golgi complex to the cell membrane.

17. dopamine is coupled to AMPK activation, which provides a substantial anti-inflammatory and bioenergetic advantage and reduces the severity of endotoxin-induced acute lung injury.

18. The result of this study showed that Dopamine D1 receptor expression is bipolar cell type-specific in the mouse retina.

19. These data suggest that D2 MSNs and specific circuits within the basal ganglia are preferentially vulnerable to HIV-1.

20. Resulting dopamine receptors (D1-to-D3) ratio indicates a strong upregulation of D1R-mediated pathways in old animals, which is particularly pronounced in the lumbar spinal cord.

Guinea Pig Dopamine Receptor D1 (DRD1) Interaktionspartner

1. Dopamine D1 receptor play role in memory consolidation.