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Cow (Bovine) Polyclonal CHRM4 Primary Antibody für IHC (p) - ABIN270800
Fong, Backman, Andersson, Scott, Danielson: Human tenocytes are stimulated to proliferate by acetylcholine through an EGFR signalling pathway. in Cell and tissue research 2013
the association of the African-specific CHRM4 SNP with cocaine dependence survived correction for multiple testing
crystal structures of the M1 and M4 muscarinic receptors bound to the inverse agonist, tiotropium
This study demonstrated that CD4+ and CD8+ T cells expressed M2 and M4 muscarinic receptors which density were significantly increased in asthmatic children in comparison with controls.
This study identify suppression of the PVHSIM1-->PAGvl/DR circuit connection as sufficient to induce overeating behavior.
[(3)H]LY2119620 to probe specifically the human M2 and M4 muscarinic receptor allosteric binding sites.
Data indicate that compounds derived from VU0152100 showed M4 muscarinic receptor (M4 mAChR) direct agoinst properties.
The data of this study suggested that the rs2067482 polymorphism may help to predict susceptibility to schizophrenia and/or therapeutic responsiveness.
Use of HM4- and green fluorescent protein-expressing trangenic mice as tissue donors in cell-based therapy validates a rodent model of Huntington disease.
analysis of allosteric agonism and modulation at the M4 muscarinic acetylcholine receptor
relative to other muscarinic receptor subtypes, the M(4) receptor could be the subtype which is selectively compromised in Alzeheimer's disease
M4 increases expression of "migratory" integrins; M4 effects resulted from inhibition of the inhibitory pathway involving the adenylyl cyclase-cyclic AMP-protein kinase A pathway
In progressive supranuclear palsy: there were no changes in M4 muscarinic receptor density
Regions in i3 including Leu272-Arg338 and Val373-Ala393 are involved in internalization of the M4 receptor; the region including Val373-Ala393 is indispensable for its recycling, whereas the other regions are dispensable for internalization and recycling.
The findings of this study indicated that the cocaine-like S(D) effects of muscarinic antagonists are primarily mediated through M1 receptors, with a minor contribution of M4 receptors.
The three receptor sets considered (mAChR, AR and TrkB receptors) intervene in modulating the conditions of the competition between nerve endings.
In the present study, the functional coupling of Gi/o protein-coupled receptors to GalR1, and the CB1 receptor subtype for endocannabinoids were analyzed in the 3xTg-AD mice model of Alzheimer's disease in the prodromal and advanced stages. In addition, the activity mediated by Gi/o protein-coupled M2/4 muscarinic receptor subtypes was also analyzed in brain areas involved in anxiety and cognition.
Muscarinic acetylcholine receptor subtype 4 is essential for cholinergic stimulation of duodenal bicarbonate secretion in mice - relationship to D cell/somatostatin
Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic Huntington's disease - YAC128 mice.
the role of the M4 receptor in alcohol consumption
We show that M4 is a major mAChR subtype mediating the cholinergic inhibition of corticostriatal glutamatergic input on both striatonigral and striatopallidal medium spiny neurons (MSNs).
The characterization of the orthosteric agonist, iperoxo, at the M(4) receptor.
These data support a role for the M4AChR subtype in mediating the antipsychotic-like activity of BuTAC.
Presence of M4 mAChR is sufficient and necessary to mediate the carbachol-induced membrane hyperpolarization and inhibition of SpECTs in laterodorsal tegmental nucleus neurons.
M4R is involved in regulation of locomotor activity, social behavior, and sensorimotor gating in mice.
Reducing M4 receptor signaling altered only select behavioral phenotypes in the Fmr1KO mouse model, suggesting that other targets are involved in the modulation of fragile X behaviors.
Chrm4 receptor is located on presynaptic glutamatergic terminals afferent to the recorded pyramidal neuron, thus decreasing glutamate release.
The muscarinic M(4) receptor is the functionally predominant subtype in mouse striatum.
Different coupling of striatal M(2)/M(4)-mAChRs to the control of DA release in CPu versus NAc suggests targets to influence DA/ACh function differentially between striatal domains.
a distinct subpopulation of neuronal M(4) mAChRs plays a critical role in modulating several important dopamine-dependent behaviors.
muscarinic analgesia is exclusively mediated by a combination of M(2) and M(4) mAChRs at both spinal and supraspinal sites.
M(4) mAChR plays a central role in mediating cholinergic control of keratinocyte migration by endogenous acetylcholine produced by these cells
M4 mAChRs modulate dopamine activity in motor tracts and act as inhibitory autoreceptors in striatum. Review.
There is a crucial role for M4 receptors in the tonic and phasic regulation of acetylcholine efflux in the hippocampus as well as in cognitive processes. The M4 receptor participates in a tonic regulatory loop contolling basal acetylcholine levels.
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown\; however, mouse studies link its function to adenylyl cyclase inhibition.
muscarinic acetylcholine receptor M4
, muscarinic acetylcholine receptor subtype 3
, cholinergic receptor, muscarinic 4
, cholinergic receptor, muscarin 4
, acetylcholine receptor, muscarinic 4
, AChR M4
, mm4 mAChR
, muscarinic acetylcholine receptor 4
, muscarinic receptor, M4 subtype
, Muscarinic acetylcholine receptor M4