anti-Thrombospondin 1 (THBS1) Antikörper

Human Thrombospondin 1 (THBS1) Interaktionspartner

1. TSP-1 effectively elevated P. gingivalis LPS (zeige IRF6 Antikörper)-induced inflammation mediated by the NF-kappaB (zeige NFKB1 Antikörper) pathway and may be critical for pathology of periodontitis.

2. These findings indicate that PRR13 (zeige PRR13 Antikörper)/THBS1 and TXN (zeige TXN Antikörper) expression could be used for the prediction of resistance to treatment of epithelial ovarian cancer patients.

3. TSP-1 appears to play an accessory role in modulating Mp activity in humans and BlaJ mice in a gender, age and muscle-dependent manner, but is unlikely a primary driver of disease progression of dysferlinopathy.

4. TSP-4 (zeige THBS4 Antikörper) A387P polymorphism, but not TSP-1 polymorphism, is an independent risk factor for acute myocardial infarction in Egyptians.

5. Results show that the thrombospondin 1 (TSP1) and its receptor CD47 (CD47 (zeige CD47 Antikörper)) axis selectively regulates NADPH oxidase 1 (Nox1 (zeige NOX1 Antikörper)) in the regulation of endothelial senescence and suggest potential targets for controlling the aging process at the molecular level.

6. 15-LOX-1 expression in colon and prostate cancer cells leads to reduced angiogenesis. These changes could be mediated by an increase in the expression of both ICAM-1 and the anti-angiogenic protein TSP-1.

7. miR (zeige MLXIP Antikörper)-98 can suppress the expression of TSP1 in the peripheral B cells of patients with allergic asthma.

8. Data indicate correlation between the levels of thrombospondin-1 and overall survival of ovarian cancer patients, suggesting thrombospondin-1 may be used as a prognostic factor in ovarian cancer patients.

9. Studies show that thrombospondin-1 (Thbs-1), is a prolific contributor to the production and modulation of ROS (zeige ROS1 Antikörper) in large conductance vessels and in the peripheral circulation. Recently, the presence of physiologically relevant circulating Thbs-1 levels was proven to also disrupt vasodilation to nitric oxide (NO) in coronary arterioles from aged animals, negatively impacting coronary blood flow reserve. [review]

10. Our findings suggest that Rab37 (zeige RAB37 Antikörper)-mediated TSP1 secretion in cancer cells suppresses metastasis and angiogenesis via a cross-talk with endothelial cells and reveal a novel component of the vesicular exocytic machinery in tumor microenvironment and tumor progression

Mouse (Murine) Thrombospondin 1 (THBS1) Interaktionspartner

1. TSP-1 (zeige GZMA Antikörper) appears to play an accessory role in modulating Mp activity in humans and BlaJ mice in a gender, age and muscle-dependent manner, but is unlikely a primary driver of disease progression of dysferlinopathy.

2. TSP-1 (zeige GZMA Antikörper) may be beneficial for maintaining BBB (zeige ALMS1 Antikörper) integrity in the early phase and functional recovery in late phase after traumatic brain injury.

3. In a laser injury-induced thrombosis model, P-selectin (zeige SELP Antikörper) modulates thrombus propagation independently of VWF (zeige VWF Antikörper) and TSP1 (zeige GZMA Antikörper)

4. These findings shed light on the mechanisms leading to beta-cell failure during metabolic stress and point to THBS1 as an interesting therapeutic target to prevent oxidative stress in type 2 diabetes.

5. cultured astrocytes isolated from an Fmr1 (zeige FMR1 Antikörper) knockout (Fmr1 (zeige FMR1 Antikörper) KO) mouse model of Fragile X (zeige FMR1 Antikörper) syndrome displayed a significant decrease in TSP-1 (zeige GZMA Antikörper) protein expression compared to the wildtype (WT) astrocytes.

6. In pulmonary hypertension TSP1 (zeige GZMA Antikörper)-CD47 (zeige CD47 Antikörper) is upregulated, and contributes to pulmonary arterial vasculopathy and dysfunction.

7. HIF-1alpha (zeige HIF1A Antikörper) induced angiogenesis by upregulating not only vascular endothelial growth factor (zeige VEGF Antikörper) but also miR (zeige MLXIP Antikörper)-21 via inhibiting a novel target gene TSP-1 (zeige GZMA Antikörper). Both of them may contribute to the protective effect of HIF-1alpha (zeige HIF1A Antikörper) on renal I/R injury.

8. the results obtained by combining bioinformatics and preclinical studies strongly suggest that targeting TSP-1 (zeige GZMA Antikörper)/CD47 (zeige CD47 Antikörper) axis may represent a valuable therapeutic alternative for hampering melanoma spreading.

9. TSP-1 (zeige GZMA Antikörper) deficiency promotes maladaptive remodelling of the ECM (zeige MMRN1 Antikörper) leading to accelerated abdominal aortic aneurysms progression.

10. TSP-1 (zeige GZMA Antikörper) suppressed insulin (zeige INS Antikörper) signaling in cultured muscle cells, which was accompanied by the activation of stress signaling such as JNK (zeige MAPK8 Antikörper), p38 (zeige CRK Antikörper), and IKK (zeige CHUK Antikörper).

Cow (Bovine) Thrombospondin 1 (THBS1) Interaktionspartner

1. Data suggest THBS1 expression predominates in luteal endothelial cells; THBS2 (zeige THBS2 Antikörper) expression predominates in luteinized granulosa cells. Luteinization down-regulates expression of THBS1/THBS2 (zeige THBS2 Antikörper), up-regulates expression of FGF2 (fibroblast growth factor 2 (zeige FGF2 Antikörper)).

2. Thrombospondin has a role in inducing RhoA (zeige RHOA Antikörper) inactivation through FAK (zeige PTK2 Antikörper)-dependent signaling to stimulate focal adhesion disassembly

3. Thrombospondin-1 and -2 were coordinately expressed in the extravascular compartment of the ovary during early follicle development. VEGF (zeige VEGFA Antikörper) was inversely expressed, with expression increasing as follicles developed.

4. Preincubation of erythroid cells with thrombospondin 1 eliminated the inhibitory activity of insulin (zeige INS Antikörper)-like growth factor

5. The cell-specific regulation of TSP-1 suggests a potential mechanism for the aberrant angiogenesis in diabetics and TSP-1 involvement in development of various vascular diabetic complications

6. The novel finding that TSP-1-induced migration is dependent on the CD44 (zeige CD44 Antikörper) receptor links 2 pathways thought to be disparate (ie, TSP-1 and HyA (zeige KDM5D Antikörper)).

Pig (Porcine) Thrombospondin 1 (THBS1) Interaktionspartner

1. These current studies were undertaken to determine how TSP-1 functions to modulate the smooth muscle cell response to IGF-I (zeige IGF1 Antikörper) and the mechanisms by which hyperglycemia regulates TSP-1 protein.

2. Increased TSP-1 expression in non-heart-beating donors may indicate a compensatory response to the reported diminished TGF-beta1 (zeige TGFB1 Antikörper) expression.

Zebrafish Thrombospondin 1 (THBS1) Interaktionspartner

1. ELL (zeige ELL Antikörper) (Eleven-Nineteen Lysine-rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulation