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Results strengthen the roles of both calpain-1 and PHLPP1 in synaptic plasticity and learning and memory, and illustrate the complexities of the interactions between multiple pathways participating in synaptic plasticity.
Genetic ablation of calpain-1 (zeige CAPN1 Proteine) ameliorates chronic pain behavior in sickle cell mice.
Our results indicate that calpain mediates cytokine-induced collagen-I synthesis and proliferation of ASMCs via the mTORC2 (zeige CRTC2 Proteine)/Akt (zeige AKT1 Proteine) signalling pathway, thereby regulating airway smooth muscle remodelling in asthma.
mutations in CAPN1 are an additional cause of ataxia in mammals, including humans.
Results indicate that calpain-1 (zeige CAPN1 Proteine) and calpain-2 (zeige CAPN2 Proteine) are differentially activated in hippocampus following seizure activity, with calpain-1 (zeige CAPN1 Proteine) activation being limited to a small population of interneurons, and possibly triggering neuroprotective events, while calpain-2 (zeige CAPN2 Proteine) is widely activated in pyramidal neurons of CA1 (zeige CA1 Proteine) and CA3 (zeige CA3 Proteine), and triggers neurodegenerative cascades.
Here we show the combined loss of glial glutamate (zeige GRIN1 Proteine) transporters GLT1 (zeige SLC1A2 Proteine) and GLAST (zeige SLC1A3 Proteine) in spinal cord caused motor neuronal death and hindlimb paralysis.
These results suggested that Streptococcus pneuomoniae PLY induces the influx of calcium in Streptococcus pneumoniae-infected macrophages, followed by calpain activation and subsequent IL-1alpha maturation and secretion.
High calpain expression is associated with brain injury.
the expression of the full-length 60-kDa calcineurin protein is down-regulated due to over-activated calpain that cleaves calcineurin to form a 45-kDa fragment.
calpains and calpastatin (zeige CAST Proteine) in patients with idiopathic pulmonary arterial hypertension (PAH) and mice with hypoxic or spontaneous (SM22 (zeige TAGLN Proteine)-5HTT (zeige SLC6A4 Proteine)(+) strain) PH, were investigated.
Rare homozygous and compound-heterozygous nonsense, missense, frameshift, and splice-site mutations in CAPN1 were identified in all hereditary spastic paraplegia affected individuals, and sequencing in additional family members confirmed the segregation of these mutations with the disease.
the cleavage of myoferlin, yielding a membrane-associated dual C2 domain 'mini-myoferlin', is reported.
Calpain-1 (zeige CAPN1 Proteine) expression is associated with poor relapse-free survival in breast cancer patients treated with trastuzumab.
Regulation of platelet-activating factor-mediated PTP1B activation by a Janus kinase 2/ calpain pathway has been reported.
HRNR (zeige HRNR Proteine) deimination improves its cross-linking by TGases and its proteolytic processing by calpain-1 (zeige CAPN1 Proteine).
calpain and protein kinase (zeige CDK7 Proteine) Calpha (zeige PRKACA Proteine) abnormal release promotes a constitutive release of matrix metalloproteinase 9 (zeige MMP9 Proteine) in peripheral blood mononuclear cells from cystic fibrosis (zeige S100A8 Proteine) patients
our findings suggest that the gene/protein expression of both CAPN1 and CAPN2 (zeige CAPN2 Proteine), as well as the ERK1 (zeige MAPK3 Proteine) and ERK2 (zeige MAPK1 Proteine) genes and related proteins, could be molecular factors associated with more invasive tumor behavior in squamous cell laryngeal cancer.
This study demonstrated that Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brain.
study is the first report on genetic variant g.-1256 A>C in the promoter region of CAPN1 gene association with the semen quality of Chinese Holstein bulls by influencing its expression
This work is supportive of the importance of CAPN1 and CAST for mean tenderness in beef.
Suppression of CANP1 resulted in the activation of caspase (zeige CASP3 Proteine) and heat-shock-protein systems which might in turn regulate apoptosis through the caspase (zeige CASP3 Proteine)-dependent cell death pathway. [CANP1]
bovine CAPN-CAST interaction were well reflected in the geometry between the pharmacophore features and its shape constraints identified using our modeled bovine CAPN1/CAST4 complex structures
This work confirms the importance of CAPN1 and CAST for tenderness in beef, provides a new effect of CAST on beef tenderness, and questions the utility of GHR (zeige GHR Proteine) as a selection marker for beef quality.
It was found that the marker c.3379G > A in the CAPN1 gene influences the Ca content in the meat of this Nelore population, with the rare genotype associated with less Ca content.
m- and micro-calpain immunosignals in the cytoplasm both along the Z disk/I band regions and in the form of intracellular stores.
Association of polymorphisms in calpain 1 (zeige CAPN1 Proteine), (mu/I) large subunit, calpastatin (zeige CAST Proteine), and cathepsin D (zeige CTSD Proteine) genes with meat quality traits in double-muscled Piemontese cattle.
Relationships of the calpain system with meat tenderness and carcass traits were examined for 94 purebred Angus bulls.
The association of polymorphisms in calpastatin (zeige CAST Proteine) and mu-calpain genes with meat tenderness in 3 French beef breeds is reported.
CAPN1 HM535412:g.157T > C showed effect on meat redness.
The decreased expression of calpain 1A mRNA during development is highly correlated with muscle protein accumulation in neonatal Sus scrofa.
Right ventricular (RV) dysfunction from acute RV pressure overload is, in part, due to activation of calpain, and calpain inhibition would therefore attenuate RV dysfunction.
catalytic site amino acid residues 105-133 contained a disulfide bond between Cys (zeige DNAJC5 Proteine)(108) and Cys (zeige DNAJC5 Proteine)(115)
Association of polymorphisms with breed characteristics indicated that the mutations in CAPN1 detected by P4, P6 primers and that resulting in the change of Hinf 1 recognition site may be related to lean meat percentage.
The activities of Calpain and PLA2 (zeige YWHAZ Proteine) on the muscle tissue of the bladders were analyzed.
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene.
calpain 1, large subunit
, CANP 1
, calcium-activated neutral proteinase 1
, calpain mu-type
, calpain-1 catalytic subunit
, calpain-1 large subunit
, calpain, large polypeptide L1
, cell proliferation-inducing gene 30 protein
, cell proliferation-inducing protein 30
, micromolar calcium activated neutral protease 1
, micromolar calcium-activated neutral protease 1
, mu-calpain large subunit