FAM134C Antikörper (AA 76-180) (Alexa Fluor 555)

Produktnummer ABIN896239

Produktdetails anti-FAM134C Antikörper

Target: FAM134C (Family with Sequence Similarity 134, Member C (FAM134C))

Bindungsspezifität: AA 76-180

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FAM134C Antikörper ist konjugiert mit Alexa Fluor 555

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit,Guinea Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FAM134C

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C/-80 °C

Informationen zur Lagerung: Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles

Haltbarkeit: 12 months

Details zu FAM134C

Target: FAM134C (Family with Sequence Similarity 134, Member C (FAM134C))

Andere Bezeichnung: FAM134C (FAM134C Produkte)

Synonyme: 1300010M03Rik antikoerper, 4933404C01Rik antikoerper, AI551748 antikoerper, RGD1561189 antikoerper, reticulophagy regulator family member 3 antikoerper, RETREG3 antikoerper, Retreg3 antikoerper

Hintergrund:

Chromosome 17 makes up over 2.5 % of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17. The FAM134C gene product has been provisionally designated FAM134C pending further characterization.

Subcellular location: Cell membrane

Synonyms: Protein FAM134C, FAM134C

Gen-ID: 162427

UniProt: Q86VR2

Pathways: SARS-CoV-2 Protein Interaktom