SLC22A4 Antikörper (Intracellular)

Produktnummer ABIN7043704

Produktdetails anti-SLC22A4 Antikörper

Target: SLC22A4 (Solute Carrier Family 22 Member 4 (SLC22A4))

Bindungsspezifität: AA 522-536, Intracellular

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SLC22A4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Verwendungszweck: A Rabbit Polyclonal antibody to OCTN1/SLC22A4 transporter.

Spezifität: Intracellular, C-terminus.

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Mouse,rat - 14 out of 15 amino acid residues identical, Human - 12 out of 15 amino acid residues identical

Produktmerkmale: Anti-OCTN1/SLC22A4 Antibody (ABIN7043704, ABIN7044225 and ABIN7044226) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize OCTN1 from mouse, rat and human samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)EQMQKVRGFR(S)GKKS, corresponding to amino acid residues 522 - 536 of mouse OCTN1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:1200

Application Dilutions Western blot wb: 1:200-1:600

Kommentare:

Cited Application: IHC

Negative Control: (ABIN7237017)

Blocking Peptide: (ABIN7237017)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW).

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Details zu SLC22A4

Target: SLC22A4 (Solute Carrier Family 22 Member 4 (SLC22A4))

Andere Bezeichnung: SLC22A4 (SLC22A4 Produkte)

Hintergrund: Organic Cation/Carnitine Transporter 1, Ergothioneine Transporter, Solute Carrier Family 22 Member 4,Organic Cation Transporter Novel (OCTN) is a subfamily of the larger Organic Cation Transporter (OCT) or SLC22 transporter family.The OCTN subfamily consists of two members in humans: OCTN1 (SLC22A4) and OCTN2 (SLC22A5) with a third member (SLC22A21) present only in rodents 1-2.The physiological role of OCTN1 (SLC22A4) has not yet been elucidated. OCTN1 is ubiquitously expressed throughout the body and transports various therapeutic agents, including organic cations and zwitterions. Ergothioneine (ET/ ERGO) a natural diet-derived antioxidant was found to be a specific substrate of OCTN1 3.OCTN1 is functionally expressed in neurons and neural stem cells and activation of the transporter could conceivably have a protective role in neurodegenerative diseases. In addition, in peripheral organs, mutations in OCTN1 are associated with susceptibility to Crohn's disease and rheumatoid arthritis suggesting that OCTN1 may play a role in inflammatory dieseases 1.

Alternative names: Organic Cation/Carnitine Transporter 1, Ergothioneine Transporter, Solute Carrier Family 22 Member 4

Gen-ID: 30805

NCBI Accession: NM_003059

UniProt: Q9Z306