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Septin 7 Antikörper (Intracellular)

SEPT7 Reaktivität: Ratte WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7043614
  • Target Alle Septin 7 (SEPT7) Antikörper anzeigen
    Septin 7 (SEPT7)
    Bindungsspezifität
    • 15
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 83-96, Intracellular
    Reaktivität
    • 35
    • 35
    • 23
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Ratte
    Wirt
    • 46
    • 2
    • 2
    Kaninchen
    Klonalität
    • 50
    Polyklonal
    Konjugat
    • 28
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Septin 7 Antikörper ist unkonjugiert
    Applikation
    • 43
    • 16
    • 14
    • 13
    • 13
    • 8
    • 7
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Verwendungszweck
    A Rabbit Polyclonal Antibody to Septin-7
    Spezifität
    Intracellular
    Kreuzreaktivität
    Human, Maus, Ratte
    Homologie
    Mouse,human - identical
    Produktmerkmale
    Anti-Septin-7 Antibody (ABIN7043614, ABIN7044544 and ABIN7044545) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot analysis. It has been designed to recognize Septin-7 from human, rat, and mouse samples.
    Aufreinigung
    Affinity purified on immobilized antigen.
    Immunogen

    Immunogen: Synthetic peptide

    Immunogen Sequence: Peptide (C)HRIKKTVQVEQSK, corresponding to amino acid residues 83-96 of rat Septin-7

    Isotyp
    IgG
    Top Product
    Discover our top product SEPT7 Primärantikörper
  • Applikationshinweise

    Antigen preadsorption control: 1 μg peptide per 1 μg antibody

    Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

    Application Dilutions Western blot wb: 1:200

    Kommentare

    Negative Control: (ABIN7236776)

    Blocking Peptide: (ABIN7236776)

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung

    Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

    Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

  • Target
    Septin 7 (SEPT7)
    Andere Bezeichnung
    SEPTIN7 (SEPT7 Produkte)
    Hintergrund
    Sept7, CDC10, SEPT7A, NBLA02942, CDC3,Septin 7 is a highly conserved GTP-binding filamentous protein. Septins are important for the organization of the actin cytoskeleton. Septin7 also plays an important role in cytokinesis, and membrane dynamics1,2.Septins were first discovered in yeast and since, 13 septin genes have been identified in mammals (SEPT1 to SEPT12 and SEPT14). The 13 gene-encoded proteins can be classified into four distinct subgroups based on their sequence homology of their domain structure2.Septins share a highly conserved structure composed of the central GTPase domain and N- and C-terminal domains of various lengths3. They self-assemble into higher-order structures, including filaments and rings in tri-, hexa-, or octameric complexes consisting of multiple septin polypeptides, which are typical for different cell types. The various septin isoforms seem to determine the function and regulation of the septin complex4.Septin-7 regulates Ca2+ entry through Orai1 by regulating the opening of the channel5.Dysregulation of septins leads to human diseases such as neurodegenerative and bleeding disorders. In non-dividing cells such as neuronal tissue and platelets septins have been associated with exocytosis1,2.

    Alternative names: Sept7, CDC10, SEPT7A, NBLA02942, CDC3
    Gen-ID
    64551
    NCBI Accession
    NM_001788
    UniProt
    Q9WVC0
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