MAGT1 Antikörper (Extracellular)

Produktnummer ABIN7043318

Produktdetails anti-MAGT1 Antikörper

Target: MAGT1 (Magnesium Transporter 1 (MAGT1))

Bindungsspezifität: AA 28-40, Extracellular

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAGT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (Cultured Cells) (IF (cc)), Live Cell Imaging (LCI)

Verwendungszweck: A Rabbit Polyclonal antibody to MAGT1 (extracellular) magnesium transporter.

Spezifität: Extracellular, N-terminus.

Kreuzreaktivität: Human, Maus, Ratte

Kreuzreaktivität (Details): The immunizing peptide bears some homology (7 out of 13 amino acid residues) with the related protein TUSC3 (Accession Q13454).

Homologie: Mouse - identical Rat 11 out of 13 amino acid residues identical

Produktmerkmale: Anti-MAGT1 (extracellular) Antibody (ABIN7043318, ABIN7044863 and ABIN7044864) is a highly specific antibody directed against an extracellular epitope of the human protein. The antibody can be used in western blot, immunohistochemistry and flow cytometry applications. It has been designed to recognize MAGT1 from mouse, rat and human samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)SAQRKKEMVLSEK, corresponding to amino acid residues 28-40 of human MAGT1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:300

Application Dilutions Western blot wb: 1:200

Kommentare:

Negative Control: (ABIN7235907)

Blocking Peptide: (ABIN7235907)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Details zu MAGT1

Target: MAGT1 (Magnesium Transporter 1 (MAGT1))

Andere Bezeichnung: MAGT1 (MAGT1 Produkte)

Hintergrund: Magnesium Transporter 1, Oligosaccharyl Transferase Subunit MAGT1, Implantation-Associated Protein, SLC58A1,Magnesium Transporter 1 (MAGT1) is a 335 amino acid peptide that is a part of the MAGT group of magnesium transporters. Magnesium (Mg2+) plays an essential cellular role, as a cofactor for ATP, nucleic acids, and numerous enzymes. It has been reported that it serves as a second messenger in intracellular signaling, and hence magnesium levels maintenance has a vast effect on cellular steady state 1. In addition to its Mg2+ transporter activity, MAGT1 was also found to be a subunit of the oligosaccharyltransferase (OST) complex, through which it is responsible for protein glycosylation 2,3.MAGT1 was shown to be related to the development of XMEN (X-linked immunodeficiency with magnesium defect, Epstein Barr Virus infection, and neoplasia) syndrome, for which Mg2+ supplementation has been shown to be beneficial. It is also related to atypical ATRX syndrome, intellectual disability and skin abnormalities.Understanding the molecular basis of the involvement of magnesium and its channels in human pathogenesis can lead to the development of new medications for many diseases.

Alternative names: Magnesium Transporter 1, Oligosaccharyl Transferase Subunit MAGT1, Implantation-Associated Protein, SLC58A1

Gen-ID: 84061

NCBI Accession: NM_032121

UniProt: Q9H0U3

Pathways: Cell RedoxHomeostasis