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Caspase 3 p12 (Cleaved-Asp175) Antikörper

Reaktivität: Human WB, ELISA, IF, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7251292
  • Target
    Caspase 3 p12
    Bindungsspezifität
    • 1
    • 1
    Cleaved-Asp175
    Reaktivität
    Human
    Wirt
    • 1
    Kaninchen
    Klonalität
    • 1
    Polyklonal
    Konjugat
    • 1
    Unkonjugiert
    Applikation
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Produktmerkmale
    Polyclonal Antibody
    Aufreinigung
    Affinity purification
    Immunogen
    Synthesized peptide derived from the Internal region of human Caspase-3 p12
    Isotyp
    IgG
  • Applikationshinweise
    WB 1:500-2000, IHC 1:50-300, IF 1:50-300
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    Caspase 3 p12
    Andere Bezeichnung
    CASP3 p12
    Hintergrund
    Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.
    Molekulargewicht

    Observed_MW: 20+35 kDa

    Calculated_MW: 32 kDa

    UniProt
    P42574
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