Synonyms: ATP binding cassette sub family B member 8,ABCB8,ABCB8,ATP binding cassette sub family B (MDR/TAP) member 8,ATP binding cassette sub family B member 8 mitochondrial,ATP-binding cassette sub-family B member 8,EST328128,M ABC1,M-ABC1,MABC1,Mitochondrial ABC protein,mitochondrial,Mitochondrial ATP binding cassette 1,Mitochondrial ATP-binding cassette 1
Background: This nuclear gene encodes a multi-pass membrane protein that is targeted to the mitochondrial inner membrane. The encoded protein is an ATP-dependent transporter that may mediate the passage of organic and inorganic molecules out of the mitochondria. Loss of function of the related gene in mouse results in a disruption of iron homeostasis between the mitochondria and cytosol. Alternative splicing results in multiple transcript variants.