Synonyms: Cas like docking,Cas scaffolding protein family member 2,CAS-L,CAS2,CasL,CASL,CASS2,Crk associated substrate related,Crk associated substrate related protein,CRK-associated substrate-related protein,dJ49G10.2 (Enhancer of Filamentation 1 (HEF1)),dJ49G10.2,dJ761I2.1 (enhancer of filamentation (HEF1)),dJ761I2.1,Enhancer of filamentation 1,Enhancer of filamentation 1 p55,HEF 1,HEF1,NEDD-9,Nedd9,Neural precursor cell expressed developmentally down-regulated protein 9,P105,Renal carcinoma antigen NY-REN-12
Background: The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants.