Synonyms: FLJ40431,Guanine nucleotide exchange factor VAV3,Protein vav 3,Protein vav3,RGD1565941,VAV 3,Vav 3 guanine nucleotide exchange factor,VAV 3 oncogene,VAV 3 protein,VAV-3,Vav3,VAV3 oncogene,VAV3 protein,VAV3
Background: This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.