SMG7 Antikörper (Smg-7 Homolog, Nonsense Mediated mRNA Decay Factor (C. Elegans))

Details for Product anti-SMG7 Antibody No. ABIN6568670
Target
Reaktivität
Human, Maus, Ratte
22
1
1
1
1
1
Wirt
Kaninchen
22
Klonalität
Polyklonal
Konjugat
Dieser SMG7 Antikörper ist unkonjugiert
1
1
1
1
1
1
1
Applikation
Western Blotting (WB)
17
9
9
6
5
4
3
1
1
1
Optionen
Immunogen Recombinant protein of human SMG7
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung SMG7 (SMG7 Antibody Abstract)
Hintergrund

Synonyms: breast cancer-associated antigen SGA-56M,C1orf16,EST1 like protein C,EST1 telomerase component homolog C,EST1-like protein C,EST1C,ever shorter telomeres 1C,FLJ23717,hSMG-7,nonsense mediated mRNA decay factor (C. elegans),Protein SMG7,SGA56M,SMG 7,SMG-7 homolog,Smg7,SMG7

Background: This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD), a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Molekulargewicht

Observed_MW: 127kDa

Calculated_MW: 122kDa/127kDa/131kDa

Gen-ID 9887
UniProt Q92540
Applikations-hinweise WB 1:200 - 1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Smg-7 Homolog, Nonsense Mediated mRNA Decay Factor (C. Elegans) (SMG7) antibody (ABIN6568670) Western blot analysis of extracts of various cell lines, using SMG7 antibody.