Synonyms: A33,Cell surface A33 antigen,Cell surface A33 antigen precursor,Glycoprotein A33 (transmembrane),Glycoprotein A33,Gpa33,GPA33,MGC129986,MGC129987,OTTHUMP00000032346,Transmembrane glycoprotein A33
Background: The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95 % of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily.