ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 7 (ABCB7) Antikörper

Details zu Produkt Nr. ABIN6568439
Target
Reaktivität
Human, Maus, Ratte
49
23
21
2
1
1
1
1
1
1
1
1
1
1
Wirt
Kaninchen
51
Klonalität
Polyklonal
Konjugat
Unkonjugiert
5
3
3
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
32
23
22
13
7
3
1
1
1
1
Optionen
Immunogen Recombinant protein of human ABCB7
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung ABCB7 (ABCB7 Antibody Abstract)
Hintergrund

Synonyms: ABC transporter 7 protein,ABC7,Abcb7,ABCB7,ASAT,Atm1p,ATP binding cassette 7,ATP binding cassette sub family B (MDR/TAP) member 7,ATP binding cassette sub family B member 7,ATP binding cassette sub family B member 7 mitochondrial,ATP binding cassette transporter 7,ATP-binding cassette sub-family B member 7,ATP-binding cassette transporter 7,EST140535,MDR7,mitochondrial,Multidrug resistance protein 7,P-glycoprotein 7,PGP7

Background: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been associated with mitochondrial iron accumulation and isodicentric (X)(q13) and sideroblastic anemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Molekulargewicht

Observed_MW: 83kDa

Calculated_MW: 78kDa/82kDa

Gen-ID 22
UniProt O75027
Pathways Transition Metal Ion Homeostasis
Applikations-hinweise WB 1:500 - 1:2000 IHC 1:50 - 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 7 (ABCB7) antibody (ABIN6568439) Western blot analysis of extracts of various cell lines, using ABCB7 antibody.
Image no. 2 for anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 7 (ABCB7) antibody (ABIN6568439) Immunohistochemistry of paraffin-embedded human gastric cancer using ABCB7 antibody.
Image no. 3 for anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 7 (ABCB7) antibody (ABIN6568439) Immunohistochemistry of paraffin-embedded rat heart using ABCB7 antibody.
Image no. 4 for anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 7 (ABCB7) antibody (ABIN6568439) Immunohistochemistry of paraffin-embedded mouse lung using ABCB7 antibody.