Synonyms: H ICSBP,H-ICSBP,HGNC:5358,HICSBP,ICSBP 1,ICSBP,ICSBP1,Interferon consensus sequence binding protein 1,Interferon consensus sequence binding protein,Interferon consensus sequence-binding protein,Interferon regulatory factor 8,IRF 8,IRF-8,Irf8,IRF8,MYLS
Background: Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection.