Synonyms: EC 3.4.24 ,Ku70 binding protein 3,KUB3,MGC134817,MGC134818,Mitochondrial inner membrane protease ATP23 homolog,XRCC6 binding protein 1
Background: The protein encoded by this gene is amplified in glioblastomas and interacts with the DNA binding subunit of DNA-dependent protein kinase. This kinase is involved in double-strand break repair (DSB), and higher expression of the encoded protein increases the efficiency of DSB. In addition, comparison to orthologous proteins strongly suggests that this protein is a metalloprotease important in the biosynthesis of mitochondrial ATPase. Several transcript variants encoding different isoforms have been found for this gene.