CYP2B6 Antikörper (AA 235-263)

Produktnummer ABIN655056

Produktdetails anti-CYP2B6 Antikörper

Target: CYP2B6 (Cytochrome P450, Family 2, Subfamily B, Polypeptide 6 (CYP2B6))

Bindungsspezifität: AA 235-263

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CYP2B6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CYP2B6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-263 amino acids from the Central region of human CYP2B6.

Klon: RB16992

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:25. WB: 1:2000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-CYP2B6 Antikörper (ABIN655056)

Okamatsu, Komatsu, Ono, Inoue, Uchide, Onaga, Endoh, Kitazawa, Hiraga, Uno, Teraoka: "Characterization of feline cytochrome P450 2B6." in: Xenobiotica; the fate of foreign compounds in biological systems, Vol. 47, Issue 2, pp. 93-102, (2017) (PubMed).

Hlavá?, Brynychová, Václavíková, Ehrlichová, Vrána, Pecha, Trnková, Kodet, Mrhalová, Kubá?ková, Gat?k, Vážan, Sou?ek: "The role of cytochromes p450 and aldo-keto reductases in prognosis of breast carcinoma patients." in: Medicine, Vol. 93, Issue 28, pp. e255, (2014) (PubMed).

Details zu CYP2B6

Target: CYP2B6 (Cytochrome P450, Family 2, Subfamily B, Polypeptide 6 (CYP2B6))

Andere Bezeichnung: CYP2B6 (CYP2B6 Produkte)

Hintergrund: This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described, however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.

Molekulargewicht: 56278

Gen-ID: 1555

NCBI Accession: NP_000758

UniProt: P20813