SIRT5 Antikörper (AA 263-292)

Produktnummer ABIN3032595

Dieses Anti-SIRT5-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SIRT5 in WB, IHC und ELISA. Geeignet für Human.

Kurzübersicht für SIRT5 Antikörper (AA 263-292) (ABIN3032595)

Target: SIRT5 (Sirtuin 5 (SIRT5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIRT5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-SIRT5 Antikörper

Bindungsspezifität: AA 263-292

Aufreinigung: Purified

Immunogen: A portion of amino acids 263-292 from the human protein was used as the immunogen for this SIRT5 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the SIRT5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. IHC (Paraffin): 1:50-1:100,Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the SIRT5 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu SIRT5

Target: SIRT5 (Sirtuin 5 (SIRT5))

Andere Bezeichnung: SIRT5

Hintergrund: SIRT5 is an NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity, however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. [UniProt]

UniProt: Q9NXA8

Pathways: SARS-CoV-2 Protein Interaktom