SIRT5 Antikörper (AA 263-292)
-
- Target Alle SIRT5 Antikörper anzeigen
- SIRT5 (Sirtuin 5 (SIRT5))
-
Bindungsspezifität
- AA 263-292
-
Reaktivität
- Human
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser SIRT5 Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- Aufreinigung
- Purified
- Immunogen
- A portion of amino acids 263-292 from the human protein was used as the immunogen for this SIRT5 antibody.
- Isotyp
- Ig Fraction
- Top Product
- Discover our top product SIRT5 Primärantikörper
-
-
- Applikationshinweise
- Titration of the SIRT5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. IHC (Paraffin): 1:50-1:100,Western blot: 1:1000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Buffer
- In 1X PBS pH 7.4 with 0.09 % sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Aliquot the SIRT5 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
-
- Target
- SIRT5 (Sirtuin 5 (SIRT5))
- Andere Bezeichnung
- SIRT5 (SIRT5 Produkte)
- Hintergrund
- SIRT5 is an NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity, however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. [UniProt]
- UniProt
- Q9NXA8
- Pathways
- SARS-CoV-2 Protein Interaktom
-