GSTM1 Antikörper (C-Term)

Produktnummer ABIN390883

Produktdetails anti-GSTM1 Antikörper

Target: GSTM1 (Glutathione S-Transferase mu 1 (GSTM1))

Bindungsspezifität: AA 184-211, C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GSTM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This GSTM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 184-211 amino acids from the C-terminal region of human GSTM1.

Klon: RB21078

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-GSTM1 Antikörper (ABIN390883)

Engman, Varghese, Lagerstedt Robinson, Malmgren, Hammarsjö, Byström, Lalitkumar, Gemzell-Danielsson: "GSTM1 gene expression correlates to leiomyoma volume regression in response to mifepristone treatment." in: PLoS ONE, Vol. 8, Issue 12, pp. e80114, (2013) (PubMed).

Details zu GSTM1

Target: GSTM1 (Glutathione S-Transferase mu 1 (GSTM1))

Andere Bezeichnung: GSTM1 (GSTM1 Produkte)

Hintergrund: GSTM1 is a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs.

Molekulargewicht: 25712

Gen-ID: 2944

NCBI Accession: NP_000552, NP_666533

UniProt: P09488

Pathways: Negative Regulation of Transporter Activity