SIRT7 Antikörper (C-Term)

Produktnummer ABIN390182

Produktdetails anti-SIRT7 Antikörper

Target: SIRT7 (Sirtuin 7 (SIRT7))

Bindungsspezifität: AA 331-360, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIRT7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: B, M, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SIRT7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 331-360 amino acids from the C-terminal region of human SIRT7.

Klon: RB1973

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:2000. IHC-P: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-SIRT7 Antikörper (ABIN390182)

Wang, Yi, Li, Cai, He, Ni, Zhou, Cheng, Jin, Fan, Qiu: "Down-regulation of sirtuin 3 is associated with poor prognosis in hepatocellular carcinoma after resection." in: BMC cancer, Vol. 14, pp. 297, (2014) (PubMed).

Sestito, Madonna, Scarponi, Cianfarani, Failla, Cavani, Girolomoni, Albanesi: "STAT3-dependent effects of IL-22 in human keratinocytes are counterregulated by sirtuin 1 through a direct inhibition of STAT3 acetylation." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 25, Issue 3, pp. 916-27, (2011) (PubMed).

Alhazzazi, Kamarajan, Joo, Huang, Verdin, DSilva, Kapila: "Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer." in: Cancer, Vol. 117, Issue 8, pp. 1670-8, (2011) (PubMed).

Details zu SIRT7

Target: SIRT7 (Sirtuin 7 (SIRT7))

Andere Bezeichnung: SIRT7 (SIRT7 Produkte)

Hintergrund: SIRT7 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.

Molekulargewicht: 44898

Gen-ID: 51547

NCBI Accession: NP_057622

UniProt: Q9NRC8